Yong Sung Cha1, Hyun Kim2, Juwon Kim3, Oh Hyun Kim1, Hyung Il Kim1, KyoungChul Cha1, Kang Hyun Lee1, Sung Oh Hwang1. 1. Department of Emergency Medicine, Wonju College of Medicine, Yonsei University, Wonju, Republic of Korea. 2. Department of Emergency Medicine, Wonju College of Medicine, Yonsei University, Wonju, Republic of Korea. Electronic address: khyun@yonsei.ac.kr. 3. Department of Laboratory Medicine, Wonju College of Medicine, Yonsei University, Wonju, Republic of Korea.
Abstract
BACKGROUND: Hemolytic anemia is one of the complications related to the chronic consumption of dapsone. However, in acute dapsone overdose, there have been few case reports regarding hemolytic anemia. Herein, we reported the prevalence and patterns of hemolytic anemia in acute dapsone overdose, and compared clinical features including mortality in the non-hemolytic anemia and the hemolytic anemia groups. METHODS: We conducted a retrospective review of 43 consecutive acute dapsone overdose cases that were diagnosed and treated at the emergency department of the Wonju Severance Christian Hospital between January 2006 and January 2014. RESULTS: There were 13 male patients (30.2%) and the ages of all patients ranged from 18 to 93 years with a median of 67 years. The ingested dose varied from a minimum of two 100-mg tablet to a maximum of twenty five 100-mg tablets. All patients had methemoglobinemia irrespective of the presence of hemolytic anemia. Among 43 patients, 30 patients (69.8%) were shown to have hemolytic anemia and hemolytic anemia developed the day after admission and persisted for more than 6 days after admission. Even though mortality rate was not significantly higher in the hemolytic anemia group, the hemolytic anemia group had significantly longer total admission and intensive care unit admission stays than the non-hemolytic group. CONCLUSIONS: A significant proportion of the patients with acute dapsone overdose is associated with occurrence of hemolytic anemia. Hemolytic anemia may be developed the day after admission and persisted for more than 6 days after admission. Therefore, monitoring of serum hemoglobin level is necessary.
BACKGROUND:Hemolytic anemia is one of the complications related to the chronic consumption of dapsone. However, in acute dapsoneoverdose, there have been few case reports regarding hemolytic anemia. Herein, we reported the prevalence and patterns of hemolytic anemia in acute dapsoneoverdose, and compared clinical features including mortality in the non-hemolytic anemia and the hemolytic anemia groups. METHODS: We conducted a retrospective review of 43 consecutive acute dapsoneoverdose cases that were diagnosed and treated at the emergency department of the Wonju Severance Christian Hospital between January 2006 and January 2014. RESULTS: There were 13 male patients (30.2%) and the ages of all patients ranged from 18 to 93 years with a median of 67 years. The ingested dose varied from a minimum of two 100-mg tablet to a maximum of twenty five 100-mg tablets. All patients had methemoglobinemia irrespective of the presence of hemolytic anemia. Among 43 patients, 30 patients (69.8%) were shown to have hemolytic anemia and hemolytic anemia developed the day after admission and persisted for more than 6 days after admission. Even though mortality rate was not significantly higher in the hemolytic anemia group, the hemolytic anemia group had significantly longer total admission and intensive care unit admission stays than the non-hemolytic group. CONCLUSIONS: A significant proportion of the patients with acute dapsoneoverdose is associated with occurrence of hemolytic anemia. Hemolytic anemia may be developed the day after admission and persisted for more than 6 days after admission. Therefore, monitoring of serum hemoglobin level is necessary.
Authors: Esther Moreno; Alba Calvo; Juana Schwartz; Iñigo Navarro-Blasco; Elena González-Peñas; Carmen Sanmartín; Juan Manuel Irache; Socorro Espuelas Journal: Pharmaceutics Date: 2019-11-13 Impact factor: 6.321
Authors: Desirée Verde Lopes; Felippe Lazar Neto; Lais C Marques; Rodrigo B O Lima; Antonio Adolfo Guerra Soares Brandão Journal: IDCases Date: 2020-11-19
Authors: Sonia Trombino; Carlo Siciliano; Debora Procopio; Federica Curcio; Annarita S Laganà; Maria Luisa Di Gioia; Roberta Cassano Journal: Pharmaceutics Date: 2022-01-30 Impact factor: 6.321