Literature DB >> 26830258

Autism and Cancer Share Risk Genes, Pathways, and Drug Targets.

Jacqueline N Crawley1, Wolf-Dietrich Heyer2, Janine M LaSalle3.   

Abstract

Autism is a neurodevelopmental disorder, diagnosed behaviorally by social and communication deficits, repetitive behaviors, and restricted interests. Recent genome-wide exome sequencing has revealed extensive overlap in risk genes for autism and for cancer. Understanding the genetic commonalities of autism(s) and cancer(s), with a focus on mechanistic pathways, could lead to repurposed therapeutics.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  DNA repair; autism; cancer; chromatin remodeling; gene; signaling pathway

Mesh：

Year:  2016        PMID： 26830258      PMCID： PMC4769654          DOI： 10.1016/j.tig.2016.01.001

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  13 in total

Review 1.  PTEN signaling in autism spectrum disorders.

Authors:  Jing Zhou; Luis F Parada
Journal:  Curr Opin Neurobiol       Date:  2012-06-02       Impact factor: 6.627

Review 2.  Causes of genome instability.

Authors:  Andrés Aguilera; Tatiana García-Muse
Journal:  Annu Rev Genet       Date:  2013-07-31       Impact factor: 16.830

Review 3.  Autism and cancer risk.

Authors:  B Crespi
Journal:  Autism Res       Date:  2011-08       Impact factor: 5.216

Review 4.  Recent advances in autism research as reflected in DSM-5 criteria for autism spectrum disorder.

Authors:  Catherine Lord; Somer L Bishop
Journal:  Annu Rev Clin Psychol       Date:  2015-01-02       Impact factor: 18.561

5.  Risk of cancer in children, adolescents, and young adults with autistic disorder.

Authors:  Huey-Ling Chiang; Chia-Jen Liu; Yu-Wen Hu; San-Chi Chen; Li-Yu Hu; Cheng-Che Shen; Chiu-Mei Yeh; Tzeng-Ji Chen; Susan Shur-Fen Gau
Journal:  J Pediatr       Date:  2014-11-18       Impact factor: 4.406

Review 6.  Behavioral phenotypes of genetic mouse models of autism.

Authors:  T M Kazdoba; P T Leach; J N Crawley
Journal:  Genes Brain Behav       Date:  2015-10-22       Impact factor: 3.449

Review 7.  Epigenetic regulation of UBE3A and roles in human neurodevelopmental disorders.

Authors:  Janine M LaSalle; Lawrence T Reiter; Stormy J Chamberlain
Journal:  Epigenomics       Date:  2015-11-20       Impact factor: 4.778

8.  The contribution of de novo coding mutations to autism spectrum disorder.

Authors:  Ivan Iossifov; Brian J O'Roak; Stephan J Sanders; Michael Ronemus; Niklas Krumm; Dan Levy; Holly A Stessman; Kali T Witherspoon; Laura Vives; Karynne E Patterson; Joshua D Smith; Bryan Paeper; Deborah A Nickerson; Jeanselle Dea; Shan Dong; Luis E Gonzalez; Jeffrey D Mandell; Shrikant M Mane; Michael T Murtha; Catherine A Sullivan; Michael F Walker; Zainulabedin Waqar; Liping Wei; A Jeremy Willsey; Boris Yamrom; Yoon-ha Lee; Ewa Grabowska; Ertugrul Dalkic; Zihua Wang; Steven Marks; Peter Andrews; Anthony Leotta; Jude Kendall; Inessa Hakker; Julie Rosenbaum; Beicong Ma; Linda Rodgers; Jennifer Troge; Giuseppe Narzisi; Seungtai Yoon; Michael C Schatz; Kenny Ye; W Richard McCombie; Jay Shendure; Evan E Eichler; Matthew W State; Michael Wigler
Journal:  Nature       Date:  2014-10-29       Impact factor: 69.504

9.  Synaptic, transcriptional and chromatin genes disrupted in autism.

Authors:  Silvia De Rubeis; Xin He; Arthur P Goldberg; Christopher S Poultney; Kaitlin Samocha; A Erucment Cicek; Yan Kou; Li Liu; Menachem Fromer; Susan Walker; Tarinder Singh; Lambertus Klei; Jack Kosmicki; Fu Shih-Chen; Branko Aleksic; Monica Biscaldi; Patrick F Bolton; Jessica M Brownfeld; Jinlu Cai; Nicholas G Campbell; Angel Carracedo; Maria H Chahrour; Andreas G Chiocchetti; Hilary Coon; Emily L Crawford; Sarah R Curran; Geraldine Dawson; Eftichia Duketis; Bridget A Fernandez; Louise Gallagher; Evan Geller; Stephen J Guter; R Sean Hill; Juliana Ionita-Laza; Patricia Jimenz Gonzalez; Helena Kilpinen; Sabine M Klauck; Alexander Kolevzon; Irene Lee; Irene Lei; Jing Lei; Terho Lehtimäki; Chiao-Feng Lin; Avi Ma'ayan; Christian R Marshall; Alison L McInnes; Benjamin Neale; Michael J Owen; Noriio Ozaki; Mara Parellada; Jeremy R Parr; Shaun Purcell; Kaija Puura; Deepthi Rajagopalan; Karola Rehnström; Abraham Reichenberg; Aniko Sabo; Michael Sachse; Stephan J Sanders; Chad Schafer; Martin Schulte-Rüther; David Skuse; Christine Stevens; Peter Szatmari; Kristiina Tammimies; Otto Valladares; Annette Voran; Wang Li-San; Lauren A Weiss; A Jeremy Willsey; Timothy W Yu; Ryan K C Yuen; Edwin H Cook; Christine M Freitag; Michael Gill; Christina M Hultman; Thomas Lehner; Aaarno Palotie; Gerard D Schellenberg; Pamela Sklar; Matthew W State; James S Sutcliffe; Christiopher A Walsh; Stephen W Scherer; Michael E Zwick; Jeffrey C Barett; David J Cutler; Kathryn Roeder; Bernie Devlin; Mark J Daly; Joseph D Buxbaum
Journal:  Nature       Date:  2014-10-29       Impact factor: 49.962

10.  Convergence of genes and cellular pathways dysregulated in autism spectrum disorders.

Authors:  Dalila Pinto; Elsa Delaby; Daniele Merico; Mafalda Barbosa; Alison Merikangas; Lambertus Klei; Bhooma Thiruvahindrapuram; Xiao Xu; Robert Ziman; Zhuozhi Wang; Jacob A S Vorstman; Ann Thompson; Regina Regan; Marion Pilorge; Giovanna Pellecchia; Alistair T Pagnamenta; Bárbara Oliveira; Christian R Marshall; Tiago R Magalhaes; Jennifer K Lowe; Jennifer L Howe; Anthony J Griswold; John Gilbert; Eftichia Duketis; Beth A Dombroski; Maretha V De Jonge; Michael Cuccaro; Emily L Crawford; Catarina T Correia; Judith Conroy; Inês C Conceição; Andreas G Chiocchetti; Jillian P Casey; Guiqing Cai; Christelle Cabrol; Nadia Bolshakova; Elena Bacchelli; Richard Anney; Steven Gallinger; Michelle Cotterchio; Graham Casey; Lonnie Zwaigenbaum; Kerstin Wittemeyer; Kirsty Wing; Simon Wallace; Herman van Engeland; Ana Tryfon; Susanne Thomson; Latha Soorya; Bernadette Rogé; Wendy Roberts; Fritz Poustka; Susana Mouga; Nancy Minshew; L Alison McInnes; Susan G McGrew; Catherine Lord; Marion Leboyer; Ann S Le Couteur; Alexander Kolevzon; Patricia Jiménez González; Suma Jacob; Richard Holt; Stephen Guter; Jonathan Green; Andrew Green; Christopher Gillberg; Bridget A Fernandez; Frederico Duque; Richard Delorme; Geraldine Dawson; Pauline Chaste; Cátia Café; Sean Brennan; Thomas Bourgeron; Patrick F Bolton; Sven Bölte; Raphael Bernier; Gillian Baird; Anthony J Bailey; Evdokia Anagnostou; Joana Almeida; Ellen M Wijsman; Veronica J Vieland; Astrid M Vicente; Gerard D Schellenberg; Margaret Pericak-Vance; Andrew D Paterson; Jeremy R Parr; Guiomar Oliveira; John I Nurnberger; Anthony P Monaco; Elena Maestrini; Sabine M Klauck; Hakon Hakonarson; Jonathan L Haines; Daniel H Geschwind; Christine M Freitag; Susan E Folstein; Sean Ennis; Hilary Coon; Agatino Battaglia; Peter Szatmari; James S Sutcliffe; Joachim Hallmayer; Michael Gill; Edwin H Cook; Joseph D Buxbaum; Bernie Devlin; Louise Gallagher; Catalina Betancur; Stephen W Scherer
Journal:  Am J Hum Genet       Date:  2014-04-24       Impact factor: 11.025
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  38 in total

1.  Cumulative Impact of Polychlorinated Biphenyl and Large Chromosomal Duplications on DNA Methylation, Chromatin, and Expression of Autism Candidate Genes.

Authors:  Keith W Dunaway; M Saharul Islam; Rochelle L Coulson; S Jesse Lopez; Annie Vogel Ciernia; Roy G Chu; Dag H Yasui; Isaac N Pessah; Paul Lott; Charles Mordaunt; Makiko Meguro-Horike; Shin-Ichi Horike; Ian Korf; Janine M LaSalle
Journal:  Cell Rep       Date:  2016-12-13       Impact factor: 9.423

Review 2.  The neural stem cell/carnitine malnutrition hypothesis: new prospects for effective reduction of autism risk?

Authors:  Vytas A Bankaitis; Zhigang Xie
Journal:  J Biol Chem       Date:  2019-11-07       Impact factor: 5.157

3.  Cellular and molecular mechanisms of neurodevelopmental disorders.

Authors:  Cristina A Ghiani; Victor Faundez
Journal:  J Neurosci Res       Date:  2017-02-22       Impact factor: 4.164

4.  Histone deacetylase inhibitor MS-275 restores social and synaptic function in a Shank3-deficient mouse model of autism.

Authors:  Kaijie Ma; Luye Qin; Emmanuel Matas; Lara J Duffney; Aiyi Liu; Zhen Yan
Journal:  Neuropsychopharmacology       Date:  2018-07       Impact factor: 7.853

5.  Learning-dependent chromatin remodeling highlights noncoding regulatory regions linked to autism.

Authors:  John N Koberstein; Shane G Poplawski; Mathieu E Wimmer; Giulia Porcari; Charlly Kao; Bruce Gomes; Davide Risso; Hakon Hakonarson; Nancy R Zhang; Robert T Schultz; Ted Abel; Lucia Peixoto
Journal:  Sci Signal       Date:  2018-01-16       Impact factor: 8.192

Review 6.  Defective phosphoinositide metabolism in autism.

Authors:  Christina Gross
Journal:  J Neurosci Res       Date:  2016-07-04       Impact factor: 4.164

7.  Placental DNA methylation levels at CYP2E1 and IRS2 are associated with child outcome in a prospective autism study.

Authors:  Yihui Zhu; Charles E Mordaunt; Dag H Yasui; Ria Marathe; Rochelle L Coulson; Keith W Dunaway; Julia M Jianu; Cheryl K Walker; Sally Ozonoff; Irva Hertz-Picciotto; Rebecca J Schmidt; Janine M LaSalle
Journal:  Hum Mol Genet       Date:  2019-08-15       Impact factor: 6.150

8.  Isoform-selective phosphoinositide 3-kinase inhibition ameliorates a broad range of fragile X syndrome-associated deficits in a mouse model.

Authors:  Christina Gross; Anwesha Banerjee; Durgesh Tiwari; Francesco Longo; Angela R White; A G Allen; Lindsay M Schroeder-Carter; Joseph C Krzeski; Nada A Elsayed; Rosemary Puckett; Eric Klann; Ralph A Rivero; Shannon L Gourley; Gary J Bassell
Journal:  Neuropsychopharmacology       Date:  2018-07-13       Impact factor: 7.853

9.  Increased prevalence of non-communicable physical health conditions among autistic adults.

Authors:  Elizabeth Weir; Carrie Allison; Varun Warrier; Simon Baron-Cohen
Journal:  Autism       Date:  2020-09-09

10.  Missense Variants in RHOBTB2 Cause a Developmental and Epileptic Encephalopathy in Humans, and Altered Levels Cause Neurological Defects in Drosophila.

Authors:  Jonas Straub; Enrico D H Konrad; Johanna Grüner; Annick Toutain; Levinus A Bok; Megan T Cho; Heather P Crawford; Holly Dubbs; Ganka Douglas; Rebekah Jobling; Diana Johnson; Bryan Krock; Mohamad A Mikati; Addie Nesbitt; Joost Nicolai; Meredith Phillips; Annapurna Poduri; Xilma R Ortiz-Gonzalez; Zöe Powis; Avni Santani; Lacey Smith; Alexander P A Stegmann; Constance Stumpel; Maaike Vreeburg; Anna Fliedner; Anne Gregor; Heinrich Sticht; Christiane Zweier
Journal:  Am J Hum Genet       Date:  2017-12-21       Impact factor: 11.043
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