| Literature DB >> 26830032 |
Jianwei Li, Anping Li, Minghua Li, Yufeng Qiao, Hui Zhang1.
Abstract
Two epimeric metabolites of Larotaxel were synthesized in eight steps from 10-DAB III as a commercial material and their structures were characterized using NMR and MS spectral data. The cytotoxicity of two metabolites was performed on breast cancer cell lines MCF-7, MX-1 and MDA-MB-231. It is remarkable that both of these two desired taxanes showed great potent cytotoxic effect.Entities:
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Year: 2016 PMID： 26830032 DOI： 10.2174/1871520616666160201151344
Source DB: PubMed Journal: Anticancer Agents Med Chem ISSN： 1871-5206 Impact factor: 2.505