Katarzyna Skórkowska-Telichowska1, Joanna Kosińska2, Monika Chwojnicka2, Dominika Tuchendler2, Mateusz Tabin2, Renata Tuchendler2, Łukasz Bobak3, Tadeusz Trziszka3, Andrzej Szuba4. 1. Department of Internal Medicine, 4th Military Hospital, Wroclaw, Poland; Division of Angiology, Wroclaw Medical University, Wroclaw, Poland. Electronic address: cathcor@poczta.onet.pl. 2. Department of Internal Medicine, 4th Military Hospital, Wroclaw, Poland. 3. Department of Animal Products Technology and Quality Management, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland. 4. Department of Internal Medicine, 4th Military Hospital, Wroclaw, Poland; Division of Angiology, Wroclaw Medical University, Wroclaw, Poland.
Abstract
PURPOSE:Patients with metabolic syndrome (MBS) have an increased risk of all-cause mortality, especially from cardiovascular disease. Egg phospholipids (PL) have been shown to exert a positive impact on cholesterol metabolism and inflammation; eggs are an important source of PL. Our study examined potential effects of egg-yolk-derived PL in non-diabetic patients with MBS. METHODS: The study group consisted of 40 patients with MBS diagnosed according to IDF criteria and divided into an experimental group receiving thePL preparation (n-6: n-3 fatty acids ratio: 1.79) and the comparison group receiving an olive oil preparation, for one month (2012/2013year). The studied dosage was 45ml (15ml 3 times per day). It was a randomized, double blinded study. RESULTS: The waist to hip ratio, GGTP levels, plasma platelet concentrations and flow mediated vasodilation of brachial artery (FMD) significantly improved in the experimental group. A significant decrease in daytime ABPM blood pressure was noticed in both groups. CONCLUSIONS: A phospholipid-enriched diet caused a significant improvement of endothelial vasodilatory function and a significant decrease in waist to hip ratio. A significant decrease in daytime systolic blood pressure were observed in both the phospholipid-enriched and oil-olive group.
RCT Entities:
PURPOSE:Patients with metabolic syndrome (MBS) have an increased risk of all-cause mortality, especially from cardiovascular disease. Egg phospholipids (PL) have been shown to exert a positive impact on cholesterol metabolism and inflammation; eggs are an important source of PL. Our study examined potential effects of egg-yolk-derived PL in non-diabeticpatients with MBS. METHODS: The study group consisted of 40 patients with MBS diagnosed according to IDF criteria and divided into an experimental group receiving the PL preparation (n-6: n-3 fatty acids ratio: 1.79) and the comparison group receiving an olive oil preparation, for one month (2012/2013year). The studied dosage was 45ml (15ml 3 times per day). It was a randomized, double blinded study. RESULTS: The waist to hip ratio, GGTP levels, plasma platelet concentrations and flow mediated vasodilation of brachial artery (FMD) significantly improved in the experimental group. A significant decrease in daytime ABPM blood pressure was noticed in both groups. CONCLUSIONS: A phospholipid-enriched diet caused a significant improvement of endothelial vasodilatory function and a significant decrease in waist to hip ratio. A significant decrease in daytime systolic blood pressure were observed in both the phospholipid-enriched and oil-olive group.
Authors: Dorian Nowacki; Helena Martynowicz; Anna Skoczyńska; Anna Wojakowska; Barbara Turczyn; Łukasz Bobak; Tadeusz Trziszka; Andrzej Szuba Journal: Sci Rep Date: 2017-09-28 Impact factor: 4.379