Literature DB >> 26827840

Experimental evaluation of inactivated and live attenuated vaccines against Mycoplasma mycoides subsp. mycoides.

Martin Mwirigi1, Isabel Nkando2, Racheal Aye3, Reuben Soi4, Horace Ochanda5, Emil Berberov6, Andrew Potter6, Volker Gerdts6, Jose Perez-Casal6, Jan Naessens3, Hezron Wesonga2.   

Abstract

The current control method for contagious bovine pleuropneumonia (CBPP) in Africa is vaccination with a live, attenuated strain of Mycoplasma mycoides subsp. mycoides (Mmm). However, this method is not very efficient and often causes serious adverse reactions. Several studies have attempted to induce protection using inactivated mycoplasma, but with widely contradictory results. Therefore, we compared the protective capacity of the live T1/44 vaccine with two inactivated preparations of Mmm strain Afadé, inoculated with an adjuvant. Protection was measured after a challenge with Afadé. The protection levels were 31%, 80.8% and 74.1% for the formalin-inactivated, heat-inactivated and live attenuated preparations, respectively. These findings indicate that low doses of heat-inactivated Mmm can offer protection to a level similar to the current live attenuated (T1/44) vaccine formulation.
Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Contagious bovine pleuropneumonia; Inactivated vaccine; Mycoplasma mycoides subsp. mycoides

Mesh：

Substances：

Year:  2015        PMID： 26827840     DOI： 10.1016/j.vetimm.2015.12.006

Source DB:  PubMed          Journal:  Vet Immunol Immunopathol        ISSN： 0165-2427            Impact factor:   2.046


  9 in total

1.  Development of a Novel Cocktail Enzyme-Linked Immunosorbent Assay and a Field-Applicable Lateral-Flow Rapid Test for Diagnosis of Contagious Bovine Pleuropneumonia.

Authors:  Martin Heller; Nimmo Gicheru; Georgina Tjipura-Zaire; Cecilia Muriuki; Mingyan Yu; Ana Botelho; Jan Naessens; Joerg Jores; Anne Liljander
Journal:  J Clin Microbiol       Date:  2016-04-06       Impact factor: 5.948

2.  Immunogenicity of inactivated Escherichia coli O157:H7 with Stx2B microparticle in mice.

Authors:  Nasim Arshadi; Seyed Latif Mousavi Gargari; Jafar Amani; Shahram Nazarian
Journal:  Iran J Basic Med Sci       Date:  2022-09       Impact factor: 2.532

3.  Immunogenic Potency of Formalin and Heat Inactivated E. coli O157:H7 in Mouse Model Administered by Different Routes.

Authors:  Nasim Arshadi; Seyed Latif Mousavi; Jafar Amani; Shahram Nazarian
Journal:  Avicenna J Med Biotechnol       Date:  2020 Jul-Sep

4.  Selected ethno-medicinal plants from Kenya with in vitro activity against major African livestock pathogens belonging to the "Mycoplasma mycoides cluster".

Authors:  Francisca Kama-Kama; Jacob Midiwo; Joseph Nganga; Naomi Maina; Elise Schiek; Leonidah Kerubo Omosa; George Osanjo; Jan Naessens
Journal:  J Ethnopharmacol       Date:  2016-09-17       Impact factor: 4.360

5.  Antimycoplasmal Activities of Compounds from Solanum aculeastrum and Piliostigma thonningii against Strains from the Mycoplasma mycoides Cluster.

Authors:  Francisca Kama-Kama; Leonidah K Omosa; Joseph Nganga; Naomi Maina; Georges Osanjo; Souaibou Yaouba; Muhammad Ilias; Jacob Midiwo; Jan Naessens
Journal:  Front Pharmacol       Date:  2017-12-21       Impact factor: 5.810

6.  Reproduction of contagious caprine pleuropneumonia reveals the ability of convalescent sera to reduce hydrogen peroxide production in vitro.

Authors:  Anne Liljander; Flavio Sacchini; Michael H Stoffel; Elise Schieck; Nadine Stokar-Regenscheit; Fabien Labroussaa; Martin Heller; Jeremy Salt; Joachim Frey; Laurent Falquet; Danny Goovaerts; Joerg Jores
Journal:  Vet Res       Date:  2019-02-08       Impact factor: 3.683

Review 7.  Recent Developments in Vaccines for Bovine Mycoplasmoses Caused by Mycoplasma bovis and Mycoplasma mycoides subsp. mycoides.

Authors:  Katarzyna Dudek; Ewelina Szacawa; Robin A J Nicholas
Journal:  Vaccines (Basel)       Date:  2021-05-24

8.  Baseline analysis of Mycoplasma mycoides subsp. mycoides antigens as targets for a DIVA assay for use with a subunit vaccine for contagious bovine pleuropneumonia.

Authors:  Harrison O Lutta; David Odongo; Arshad Mather; Jose Perez-Casal; Andrew Potter; Volker Gerdts; Emil M Berberov; Tracy Prysliak; Martina Kyallo; Alexander Kipronoh; Moses Olum; Roger Pelle; Jan Naessens
Journal:  BMC Vet Res       Date:  2020-07-10       Impact factor: 2.741

9.  Mycoplasmas are no exception to extracellular vesicles release: Revisiting old concepts.

Authors:  Patrice Gaurivaud; Sarah Ganter; Alexandre Villard; Lucia Manso-Silvan; Didier Chevret; Christelle Boulé; Véronique Monnet; Florence Tardy
Journal:  PLoS One       Date:  2018-11-28       Impact factor: 3.240
  9 in total

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