| Literature DB >> 26827796 |
Zhong Peng1, Wan Liang2, Wenjing Liu3, Bin Wu4, Biao Tang5, Chen Tan6, Rui Zhou7, Huanchun Chen8.
Abstract
Pasteurella multocida infects various domestic and feral animals, generally causing clinical disease. To investigate P. multocida disease in cattle, we sequenced the complete genome of P. multocida HB01 (GenBank accession CP006976), a serotype A organism isolated from a cow in China. The genome is composed of a single circular chromosome of 2,416,068 base pairs containing 2212 protein-coding sequences, 6 ribosomal rRNA operons, and 56 tRNA genes. The present study confirms that P. multocida HB01 possesses a more complete metabolic pathway with an intact trichloroacetic acid cycle for anabolism compared with A. pleuropneumoniae and Haemophilus parasuis. This is the first time that this metabolic mechanism of P. multocida has been described. We also identified a full spectrum of genes related to known virulence factors of P. multocida. The differences in virulence factors between strains of different serotypes and origins were also compared. This comprehensive comparative genome analysis will help in further studies of the metabolic pathways, genetic basis of serotype, and virulence of P. multocida.Entities:
Keywords: Comparative analysis; Genome sequencing; Metabolism; Pasteurella multocida; Virulence factors
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Year: 2016 PMID： 26827796 DOI： 10.1016/j.gene.2016.01.041
Source DB: PubMed Journal: Gene ISSN： 0378-1119 Impact factor: 3.688