| Literature DB >> 26827640 |
Christiane Möller1, Anne Hafkemeijer2, Yolande A L Pijnenburg1, Serge A R B Rombouts2, Jeroen van der Grond3, Elise Dopper4, John van Swieten5, Adriaan Versteeg6, Martijn D Steenwijk6, Frederik Barkhof6, Philip Scheltens1, Hugo Vrenken7, Wiesje M van der Flier8.
Abstract
We examined patterns of cortical thickness loss and cognitive decline over time in 19 patients with Alzheimer's disease (AD), 10 with behavioral variant frontotemporal dementia (bvFTD), and 34 controls with a mean interval of 2.1 ± 0.4 years. We measured vertexwise and regional cortical thickness changes of 6 lobar regions of interest between groups with the longitudinal FreeSurfer pipeline. Compared with controls, AD and bvFTD had a steeper rate of cognitive decline and showed faster cortical thinning per year. Decrease of thickness over time was highest in AD and generalized throughout the whole brain, most pronounced posteriorly, whereas bvFTD patients had a more selective loss in frontal cortex and in anterior parts of the temporal lobes. In a direct comparison, AD patients showed faster cortical thinning in the insula, temporal, and parietal regions, whereas bvFTD patients only showed faster cortical thinning in the orbitofrontal gyrus. Decline of cognitive performances was in line with cortical thinning and deteriorated the most in AD patients.Entities:
Keywords: Alzheimer's disease; Behavioral variant frontotemporal dementia; Cognition; Gray matter thickness; Longitudinal
Mesh：
Year: 2015 PMID： 26827640 DOI： 10.1016/j.neurobiolaging.2015.10.020
Source DB: PubMed Journal: Neurobiol Aging ISSN： 0197-4580 Impact factor: 4.673