Literature DB >> 26826582

The importance of triazole scaffold in the development of anticonvulsant agents.

Adile Ayati1, Saeed Emami2, Alireza Foroumadi3.   

Abstract

Epilepsy is one of the most important neurological disorders with high prevalence worldwide. Many epileptic patients are not completely treated with available drugs and need multiple therapies. Also, many antiepileptic drugs have shown unwanted side effects and drug interactions. Therefore there are continuing interests to find new anticonvulsant drugs. Triazole ring has been found in the structure of many compounds with diverse biological effects. Due to the success of several triazole-containing drugs that entered the pharmaceutical market as CNS-active drugs, this class of heterocyclic compounds has great importance for discovery and development of new anticonvulsant drugs. In this article, we have tried to summarize the latest efforts which have been made in the design and development of triazole-derived anticonvulsant agents.
Copyright © 2016 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  1,2,4-Triazole; Anticonvulsant agents; Antiepileptic drugs; Epilepsy; Fused triazoles

Mesh：

Substances：

Year:  2016        PMID： 26826582     DOI： 10.1016/j.ejmech.2016.01.009

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  8 in total

1.  Derivatives of a new heterocyclic system - pyrano[3,4-c][1,2,4]triazolo[4,3-a]pyridines: synthesis, docking analysis and neurotropic activity.

Authors:  Ervand G Paronikyan; Anthi Petrou; Maria Fesatidou; Athina Geronikaki; Shushanik Sh Dashyan; Suren S Mamyan; Ruzanna G Paronikyan; Ivetta M Nazaryan; Hasmik H Hakopyan
Journal:  Medchemcomm       Date:  2019-06-19       Impact factor: 3.597

2.  Synthesis of 3-(5-amino-1H-1,2,4-triazol-3-yl)propanamides and their tautomerism.

Authors:  Felicia Phei Lin Lim; Lin Yuing Tan; Edward R T Tiekink; Anton V Dolzhenko
Journal:  RSC Adv       Date:  2018-06-19       Impact factor: 3.361

Review 3.  1,2,3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview.

Authors:  Khurshed Bozorov; Jiangyu Zhao; Haji A Aisa
Journal:  Bioorg Med Chem       Date:  2019-07-04       Impact factor: 3.641

4.  Design, synthesis, and anticonvulsant effects evaluation of nonimidazole histamine H3 receptor antagonists/inverse agonists containing triazole moiety.

Authors:  Mingxia Song; Rui Yan; Yanhui Zhang; Dongfu Guo; Naiming Zhou; XianQing Deng
Journal:  J Enzyme Inhib Med Chem       Date:  2020-12       Impact factor: 5.051

5.  Revisiting the Therapeutic Potential of Bothrops jararaca Venom: Screening for Novel Activities Using Connectivity Mapping.

Authors:  Carolina Alves Nicolau; Alyson Prorock; Yongde Bao; Ana Gisele da Costa Neves-Ferreira; Richard Hemmi Valente; Jay William Fox
Journal:  Toxins (Basel)       Date:  2018-02-06       Impact factor: 4.546

Review 6.  Recent developments on triazole nucleus in anticonvulsant compounds: a review.

Authors:  Ming-Xia Song; Xian-Qing Deng
Journal:  J Enzyme Inhib Med Chem       Date:  2018-12       Impact factor: 5.051

7.  Synthesis of a New Series of Nitrogen/Sulfur Heterocycles by Linking Four Rings: Indole; 1,2,4-Triazole; Pyridazine; and Quinoxaline.

Authors:  Ahmed T A Boraei; Ahmed A M Sarhan; Sammer Yousuf; Assem Barakat
Journal:  Molecules       Date:  2020-01-21       Impact factor: 4.411

8.  Effect of Chronic Administration of 5-(3-chlorophenyl)-4-Hexyl-2,4 -Dihydro-3H-1,2,4-Triazole-3-Thione (TP-315)-A New Anticonvulsant Drug Candidate-On Living Organisms.

Authors:  Anna Makuch-Kocka; Marta Andres-Mach; Mirosław Zagaja; Anna Śmiech; Magdalena Pizoń; Jolanta Flieger; Judyta Cielecka-Piontek; Tomasz Plech
Journal:  Int J Mol Sci       Date:  2021-03-25       Impact factor: 5.923
  8 in total

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