Yoko Kaichi1, Go Okada2, Masahiro Takamura2, Shigeru Toki3, Yuji Akiyama4, Toru Higaki5, Yoshiko Matsubara6, Yasumasa Okamoto2, Shigeto Yamawaki2, Kazuo Awai5. 1. Diagnostic Radiology, Graduate School and Institute of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, Japan. Electronic address: kaichi@hiroshima-u.ac.jp. 2. Department of Psychiatry and Neurosciences, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, Japan. 3. Daijikai Mihara Hospital, Nakano-cho 6-31-1, Mihara, Hiroshima 723-0003, Japan. 4. Radiology, Hiroshima University Hospital, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, Japan. 5. Diagnostic Radiology, Graduate School and Institute of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, Japan. 6. Department of Radiology, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, Japan.
Abstract
BACKGROUND: A few studies have used pseudo-continuous arterial spin labeling (pCASL) to assess the regional cerebral blood flow (rCBF) in patients with major depressive disorder (MDD). However, rCBF changes during treatment with escitalopram have not been studied in detail. We used pCASL to investigate the effect of 6-week escitalopram treatment on the rCBF in MDD patients. METHODS: We subjected 53 MDD patients and 36 controls to pCASL (T1, baseline). The patients then received treatment with escitalopram for 6 weeks and 27 were scanned again (T2). We used selected regions of interest that exhibited differences between the controls and patients at T1 and compared the T2 rCBF in the patients with the T1 rCBF of the controls. We also compared the T1 and T2 rCBF in the patients to assess their response to escitalopram. RESULTS: After 6-week treatment with escitalopram, the rCBF in the patients' left inferior temporal gyri, the middle- and inferior frontal gyri, and the subgenual anterior cingulate, which had been higher at T1 than in the controls, was decreased. Their rCBF in the right lingual gyrus remained significantly lower at T2. LIMITATION: We did not have a placebo-control group and the number of patients available at T2 was small. CONCLUSION: In MDD patients, 6-week escitalopram treatment elicited significant rCBF changes toward normalization in most of the areas that had shown significant differences between the patients and the controls at T1. The persistence of rCBF anomalies in the right lingual gyrus may be a trait marker of MDD.
BACKGROUND: A few studies have used pseudo-continuous arterial spin labeling (pCASL) to assess the regional cerebral blood flow (rCBF) in patients with major depressive disorder (MDD). However, rCBF changes during treatment with escitalopram have not been studied in detail. We used pCASL to investigate the effect of 6-week escitalopram treatment on the rCBF in MDDpatients. METHODS: We subjected 53 MDDpatients and 36 controls to pCASL (T1, baseline). The patients then received treatment with escitalopram for 6 weeks and 27 were scanned again (T2). We used selected regions of interest that exhibited differences between the controls and patients at T1 and compared the T2 rCBF in the patients with the T1 rCBF of the controls. We also compared the T1 and T2 rCBF in the patients to assess their response to escitalopram. RESULTS: After 6-week treatment with escitalopram, the rCBF in the patients' left inferior temporal gyri, the middle- and inferior frontal gyri, and the subgenual anterior cingulate, which had been higher at T1 than in the controls, was decreased. Their rCBF in the right lingual gyrus remained significantly lower at T2. LIMITATION: We did not have a placebo-control group and the number of patients available at T2 was small. CONCLUSION: In MDDpatients, 6-week escitalopram treatment elicited significant rCBF changes toward normalization in most of the areas that had shown significant differences between the patients and the controls at T1. The persistence of rCBF anomalies in the right lingual gyrus may be a trait marker of MDD.
Authors: Margarita Abi Zeid Daou; Brian D Boyd; Manus J Donahue; Kimberly Albert; Warren D Taylor Journal: J Affect Disord Date: 2017-03-16 Impact factor: 4.839
Authors: Crystal M Cooper; Cherise R Chin Fatt; Manish Jha; Gregory A Fonzo; Bruce D Grannemann; Thomas Carmody; Aasia Ali; Sina Aslan; Jorge R C Almeida; Thilo Deckersbach; Maurizio Fava; Benji T Kurian; Patrick J McGrath; Melvin McInnis; Ramin V Parsey; Myrna Weissman; Mary L Phillips; Hanzhang Lu; Amit Etkin; Madhukar H Trivedi Journal: EClinicalMedicine Date: 2019-05-18