| Literature DB >> 26826523 |
Dixon H Xu1, Ziwen Zhu2, Mark R Wakefield2, Huaping Xiao3, Qian Bai2, Yujiang Fang4.
Abstract
Interleukin-11 (IL-11) is a member of the glycoprotein-130 (GP-130) cytokines that utilizes the GP-130 signaling pathway shared by other cytokines of the same family. Traditionally regarded as an anti-inflammatory cytokine, IL-11 also demonstrates its role as a proinflammatory cytokine, suggesting its complex role in immune response. In recent years, IL-11 has an emerging role in various inflammation-associated cancers. In this review, we aim to discuss IL-11 signaling pathway, to explore the role of IL-11 in immunity and various cancers, and to provide a therapeutic perspective of strategies utilized to interfere IL-11 signaling in cancer cells.Entities:
Keywords: Cancer; Cytokine; IL-11; Immune response
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Year: 2016 PMID： 26826523 DOI： 10.1016/j.canlet.2016.01.004
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679