Literature DB >> 26825934

Successful pregnancy with autoimmune cirrhosis.

António Braga1, Jorge Braga1.   

Abstract

Pregnancy with liver cirrhosis is a rare and dangerous event that exposes mother and fetus to potentially lethal risks. During pregnancy, hepatic decompensation could suffice and the development of hepatic failure and encephalopathy could occur. The incidence of obstetric complications is also increased with a high rate of pre-eclampsia, postpartum bleeding, preterm delivery and stillbirth. We report a case of a 27-year-old woman with autoimmune hepatitis and liver cirrhosis complicated by splenomegaly, oesophageal varices and severe thrombocytopaenia. During pregnancy, close clinical and analytical surveillance was performed. She was medicated with corticosteroids, azathioprine and propranolol. At the 25th week of gestation, an upper gastrointestinal endoscopy was performed to control oesophageal varices. This patient had an uneventful pregnancy until 37 weeks. At 37th week of gestation, after spontaneous rupture of membranes, signs of acute fetal distress were observed, and an urgent caesarean was performed. Good neonatal and maternal outcomes were achieved. 2016 BMJ Publishing Group Ltd.

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Year:  2016        PMID: 26825934      PMCID: PMC4735270          DOI: 10.1136/bcr-2015-212501

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  20 in total

1.  EASL Clinical Practice Guidelines: Autoimmune hepatitis.

Authors: 
Journal:  J Hepatol       Date:  2015-09-01       Impact factor: 25.083

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Journal:  Gastroenterol Hepatol (N Y)       Date:  2013-10

Review 3.  Outcomes of pregnancy in women with autoimmune hepatitis.

Authors:  Rachel H Westbrook; Andrew D Yeoman; Stephen Kriese; Michael A Heneghan
Journal:  J Autoimmun       Date:  2012-01-17       Impact factor: 7.094

4.  Pregnancy and autoimmune hepatitis.

Authors:  Misael Uribe; Norberto C Chavez-Tapia; Nahum Mendez-Sanchez
Journal:  Ann Hepatol       Date:  2006 Jul-Sep       Impact factor: 2.400

5.  Pregnancy in patients with hepatic cirrhosis. Management and outcome.

Authors:  M J Whelton; S Sherlock
Journal:  Lancet       Date:  1968-11-09       Impact factor: 79.321

Review 6.  Autoimmune hepatitis.

Authors:  Ansgar W Lohse; Giorgina Mieli-Vergani
Journal:  J Hepatol       Date:  2010-12-15       Impact factor: 25.083

7.  Management and outcome of pregnancy in autoimmune hepatitis.

Authors:  M A Heneghan; S M Norris; J G O'Grady; P M Harrison; I G McFarlane
Journal:  Gut       Date:  2001-01       Impact factor: 23.059

Review 8.  Liver disease in pregnancy.

Authors:  Fabiana S Benjaminov; Jenny Heathcote
Journal:  Am J Gastroenterol       Date:  2004-12       Impact factor: 10.864

Review 9.  Liver disease in pregnancy.

Authors:  Noel M Lee; Carla W Brady
Journal:  World J Gastroenterol       Date:  2009-02-28       Impact factor: 5.742

Review 10.  Liver disease in pregnancy.

Authors:  J Eileen Hay
Journal:  Hepatology       Date:  2008-03       Impact factor: 17.425

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  1 in total

1.  Systematic review with meta-analysis: outcomes of pregnancy in patients with autoimmune hepatitis.

Authors:  Tengfei Si; Zhenlin Huang; Robert Hegarty; Yun Ma; Michael A Heneghan
Journal:  Aliment Pharmacol Ther       Date:  2022-04-08       Impact factor: 9.524

  1 in total

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