Literature DB >> 2682590

Ion pair transport across membranes.

R Neubert1.   

Abstract

The present review discusses drugs and counter ions suitable for ion pair transport (IPT). Ion pairing is shown to effectively increase the lipophilicity and transport rate of polar drugs across lipid membranes. The proposed mechanisms of IPT are discussed in detail. A marked change in drug properties upon ion pair formation is necessary to improve the bioavailability of hydrophilic ionizable drugs.

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Year:  1989        PMID： 2682590     DOI： 10.1023/a:1015963128124

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  22 in total

1.  The use of sacs of everted small intestine for the study of the transference of substances from the mucosal to the serosal surface.

Authors:  T H WILSON; G WISEMAN
Journal:  J Physiol       Date:  1954-01       Impact factor: 5.182

2.  Simulated absorption of doxorubicin as ion pair.

Authors:  M Trotta; M R Gasco; M E Carlotti
Journal:  Pharm Acta Helv       Date:  1988

3.  Lipophilisation of hydrophilic compounds. Consequences on transepidermal and intestinal transport of trospium chloride.

Authors:  P Langguth; E Mutschler
Journal:  Arzneimittelforschung       Date:  1987-12

4.  Partition of alkylsulfates of quaternary ammonium compounds: structure dependence and transport study.

Authors:  F M Plakogiannis; E J Lien; C Harris; J A Biles
Journal:  J Pharm Sci       Date:  1970-02       Impact factor: 3.534

5.  [Drug permeation through artificial lipoid membranes. 19. The mechanism of ion pair permeation--alkali ion countertransport].

Authors:  R Neubert; W Fürst; H Schleiermacher
Journal:  Pharmazie       Date:  1985-07       Impact factor: 1.267

6.  [Membrane diffusion of homologous organic salts of tridihexethyl].

Authors:  B C Lippold; W A Lettenbauer
Journal:  Pharmazie       Date:  1978-04       Impact factor: 1.267

7.  [Drug permeation through synthetic lipoid membranes. 18. The mechanism of ion-pair permeation proton countertransport].

Authors:  R Neubert; W Fürst; H Schleiermacher
Journal:  Pharmazie       Date:  1985-06       Impact factor: 1.267

8.  The influence of bile salts on the absorption in vitro and in vivo of propranolol.

Authors:  M R Gasco; M Trotta; M Eandi
Journal:  J Pharm Biomed Anal       Date:  1984       Impact factor: 3.935

9.  Non-enhancement of sodium cromoglycate intestinal absorption by quaternary ammonium ions. An effect of salt on ion-pair formation?

Authors:  N Schurgers; C J de Blaey; E Tomlinson
Journal:  J Pharm Pharmacol       Date:  1984-01       Impact factor: 3.765

10.  [Drug transport through artificial lipoid membranes. 21. Ion pair transport with alkyl salicylic acids].

Authors:  R Neubert; W Fürst; H Schleiermacher; P Bergmann; E Stolte
Journal:  Pharmazie       Date:  1987-05       Impact factor: 1.267
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  17 in total

1.  The apparent lipophilicity of quaternary ammonium ions is influenced by galvani potential difference, not ion-pairing: a cyclic voltammetry study.

Authors:  G Bouchard; P A Carrupt; B Testa; V Gobry; H H Girault
Journal:  Pharm Res       Date:  2001-05       Impact factor: 4.200

2.  Enabling the intestinal absorption of highly polar antiviral agents: ion-pair facilitated membrane permeation of zanamivir heptyl ester and guanidino oseltamivir.

Authors:  Jonathan M Miller; Arik Dahan; Deepak Gupta; Sheeba Varghese; Gordon L Amidon
Journal:  Mol Pharm       Date:  2010-08-02       Impact factor: 4.939

Review 3.  Applications of the ion-pair concept to hydrophilic substances with special emphasis on peptides.

Authors:  D Quintanar-Guerrero; E Allémann; H Fessi; E Doelker
Journal:  Pharm Res       Date:  1997-02       Impact factor: 4.200

4.  Enhanced percutaneous absoption of piroxicam via salt formation with ethanolamines.

Authors:  Hyun-Ah Cheong; Hoo-Kyun Choi
Journal:  Pharm Res       Date:  2002-09       Impact factor: 4.200

5.  In situ artificial membrane permeation assay under hydrodynamic control: permeability-pH profiles of warfarin and verapamil.

Authors:  Matej Velický; Dan F Bradley; Kin Y Tam; Robert A W Dryfe
Journal:  Pharm Res       Date:  2010-05-07       Impact factor: 4.200

6.  Detergent-enabled transport of proteins and nucleic acids through hydrophobic solvents.

Authors:  L E Bromberg; A M Klibanov
Journal:  Proc Natl Acad Sci U S A       Date:  1994-01-04       Impact factor: 11.205

7.  Bilayer composition, temperature, speciation effects and the role of bilayer chain ordering on partitioning of dexamethasone and its 21-phosphate.

Authors:  Sweta Modi; Bradley D Anderson
Journal:  Pharm Res       Date:  2013-07-25       Impact factor: 4.200

8.  Ion-pair partition of quarternary ammonium drugs: the influence of counter ions of different lipophilicity, size, and flexibility.

Authors:  K Takács-Novák; G Szász
Journal:  Pharm Res       Date:  1999-10       Impact factor: 4.200

9.  Dissolution and partitioning behavior of hydrophobic ion-paired compounds.

Authors:  C S Lengsfeld; D Pitera; M Manning; T W Randolph
Journal:  Pharm Res       Date:  2002-10       Impact factor: 4.200

10.  Targeted live-cell nuclear delivery of the DNA 'light-switching' Ru(II) complex via ion-pairing with chlorophenolate counter-anions: the critical role of binding stability and lipophilicity of the ion-pairing complexes.

Authors:  Xi-Juan Chao; Miao Tang; Rong Huang; Chun-Hua Huang; Jie Shao; Zhu-Ying Yan; Ben-Zhan Zhu
Journal:  Nucleic Acids Res       Date:  2019-11-18       Impact factor: 16.971
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