Min Lu1, Yuanhong Xu2, Liying Lv1, Min Zhang1. 1. Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, No. 218, Jixi Road, 230022, Hefei, China. 2. Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, No. 218, Jixi Road, 230022, Hefei, China. xyh20150428@126.com.
Abstract
PURPOSE: Vitamin D is widely used for bone growth and normal insulin secretion; however, the association between vitamin D status and gestational diabetes risk is controversial. This meta-analysis aimed to quantitatively evaluate the association between vitamin status and risk of gestational diabetes. METHODS: We performed a systematic search on the PubMed, EmBase, and Cochrane Library databases in January 2015 to obtain observational studies studying gestational diabetes risk in relation to vitamin D status. Odds ratios (ORs) with 95 % confidence intervals (CIs) were used to measure the association between vitamin D status and the risk of gestational diabetes. RESULTS: A total of 20 observational studies were included in the final analysis containing 16,515 individuals. Overall, maternal vitamin D insufficiency was found to be associated with a greater risk of gestational diabetes (RR 1.45; 95 % CI 1.15-1.83; P < 0.001). Subgroup analysis indicated that this association might differ based on countries, study design, assessment of vitamin D levels, sample size, age at baseline, adjusted models, and study quality. CONCLUSIONS: This meta-analysis revealed that maternal vitamin D insufficiency is associated with increased risk of gestational diabetes.
PURPOSE:Vitamin D is widely used for bone growth and normal insulin secretion; however, the association between vitamin D status and gestational diabetes risk is controversial. This meta-analysis aimed to quantitatively evaluate the association between vitamin status and risk of gestational diabetes. METHODS: We performed a systematic search on the PubMed, EmBase, and Cochrane Library databases in January 2015 to obtain observational studies studying gestational diabetes risk in relation to vitamin D status. Odds ratios (ORs) with 95 % confidence intervals (CIs) were used to measure the association between vitamin D status and the risk of gestational diabetes. RESULTS: A total of 20 observational studies were included in the final analysis containing 16,515 individuals. Overall, maternal vitamin Dinsufficiency was found to be associated with a greater risk of gestational diabetes (RR 1.45; 95 % CI 1.15-1.83; P < 0.001). Subgroup analysis indicated that this association might differ based on countries, study design, assessment of vitamin D levels, sample size, age at baseline, adjusted models, and study quality. CONCLUSIONS: This meta-analysis revealed that maternal vitamin Dinsufficiency is associated with increased risk of gestational diabetes.
Entities:
Keywords:
Association; Gestational diabetes; Meta-analysis; Vitamin D status
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