Wesley T O'Neal1, Waqas Qureshi, Zhu-Ming Zhang, Elsayed Z Soliman. 1. aDepartment of Internal Medicine bDepartment of Internal Medicine, Section on Cardiology cEpidemiological Cardiology Research Center (EPICARE), Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Abstract
AIMS: The aim of this study was to examine the bidirectional association between atrial fibrillation and congestive heart failure (CHF) in older adults. METHODS: We studied the association of atrial fibrillation at entry with incident CHF (N = 5281; 85% white, 42% male) and the association of CHF at entry with incident atrial fibrillation (N = 5233; 85% white, 42% male) in the Cardiovascular Health Study (CHS). Baseline atrial fibrillation was identified during the study electrocardiogram and by self-reported history, and incident cases were identified during subsequent study electrocardiograms and hospitalization data. Baseline CHF was identified by self-reported history and adjudication of medical records, and incident cases were identified using hospitalization data. Cox regression was used to compute hazard ratios and 95% confidence intervals (CIs) for the association between atrial fibrillation and incident CHF, and CHF and incident atrial fibrillation, separately. RESULTS: Over a median follow-up of 12.6 years, 534 (10%) participants developed atrial fibrillation. CHF was associated with an increased risk of atrial fibrillation (hazard ratio 2.0, 95% CI 1.4, 3.0). A total of 1692 (32%) participants developed CHF over a median follow-up of 11.7 years and atrial fibrillation was associated with an increased risk of CHF (hazard ratio 1.9, 95% CI 1.5, 2.2). CONCLUSION: Our results suggest that a bidirectional relationship exists between atrial fibrillation and CHF, with each condition influencing the development of the other.
AIMS: The aim of this study was to examine the bidirectional association between atrial fibrillation and congestive heart failure (CHF) in older adults. METHODS: We studied the association of atrial fibrillation at entry with incident CHF (N = 5281; 85% white, 42% male) and the association of CHF at entry with incident atrial fibrillation (N = 5233; 85% white, 42% male) in the Cardiovascular Health Study (CHS). Baseline atrial fibrillation was identified during the study electrocardiogram and by self-reported history, and incident cases were identified during subsequent study electrocardiograms and hospitalization data. Baseline CHF was identified by self-reported history and adjudication of medical records, and incident cases were identified using hospitalization data. Cox regression was used to compute hazard ratios and 95% confidence intervals (CIs) for the association between atrial fibrillation and incident CHF, and CHF and incident atrial fibrillation, separately. RESULTS: Over a median follow-up of 12.6 years, 534 (10%) participants developed atrial fibrillation. CHF was associated with an increased risk of atrial fibrillation (hazard ratio 2.0, 95% CI 1.4, 3.0). A total of 1692 (32%) participants developed CHF over a median follow-up of 11.7 years and atrial fibrillation was associated with an increased risk of CHF (hazard ratio 1.9, 95% CI 1.5, 2.2). CONCLUSION: Our results suggest that a bidirectional relationship exists between atrial fibrillation and CHF, with each condition influencing the development of the other.
Authors: Nikhil Patel; Wesley T O'Neal; S Patrick Whalen; Elsayed Z Soliman Journal: Ann Noninvasive Electrocardiol Date: 2017-06-29 Impact factor: 1.468
Authors: Elsayed Z Soliman; Akm F Rahman; Zhu-Ming Zhang; Carlos J Rodriguez; Tara I Chang; Jeffrey T Bates; Lama Ghazi; Joseph L Blackshear; Michel Chonchol; Lawrence J Fine; Walter T Ambrosius; Cora E Lewis Journal: Hypertension Date: 2020-05-04 Impact factor: 10.190
Authors: Charles D Nicoli; Wesley T O'Neal; Emily B Levitan; Matthew J Singleton; Suzanne E Judd; George Howard; Monika M Safford; Elsayed Z Soliman Journal: Heart Date: 2021-05-24 Impact factor: 5.994