BACKGROUND: Evidence demonstrates that the T allele of the single-nucleotide polymorphism rs405509 as the apolipoprotein E (APOE) promoter is a risk factor for Alzheimer's disease (AD). However, it is unclear the APOE-rs405509 interaction effect on brain spontaneous activity. METHODS: We analyzed the interaction of the rs405509 TT allele and the APOE ε4 allele on cognitive performances measured using neuropsychological tests and brain default mode network (DMN) defined by independent component analysis using based on resting-state functional magnetic resonance imaging data among the non-demented elderly people. RESULTS: Significant interaction was found between rs405509 and APOE on general mental status, memory and attention (p<0.05). Functional network analysis showed a significantly APOE-rs405509 interaction on anterior cingulate gyrus, medial frontal region and precuneus at anterior and posterior DMN (False Discovery Rate p<0.05). Additionally, significant correlations were found between cognitive performance and DMN connectivity (p<0.05). CONCLUSION: The data indicates that the APOE-rs405509 interaction impairs elderly's cognitive performance through brain functional network.
BACKGROUND: Evidence demonstrates that the T allele of the single-nucleotide polymorphism rs405509 as the apolipoprotein E (APOE) promoter is a risk factor for Alzheimer's disease (AD). However, it is unclear the APOE-rs405509 interaction effect on brain spontaneous activity. METHODS: We analyzed the interaction of the rs405509 TT allele and the APOE ε4 allele on cognitive performances measured using neuropsychological tests and brain default mode network (DMN) defined by independent component analysis using based on resting-state functional magnetic resonance imaging data among the non-demented elderly people. RESULTS: Significant interaction was found between rs405509 and APOE on general mental status, memory and attention (p<0.05). Functional network analysis showed a significantly APOE-rs405509 interaction on anterior cingulate gyrus, medial frontal region and precuneus at anterior and posterior DMN (False Discovery Rate p<0.05). Additionally, significant correlations were found between cognitive performance and DMN connectivity (p<0.05). CONCLUSION: The data indicates that the APOE-rs405509 interaction impairs elderly's cognitive performance through brain functional network.
Authors: Kyu Yeong Choi; Jang Jae Lee; Tamil Iniyan Gunasekaran; Sarang Kang; Wooje Lee; Jangho Jeong; Ho Jae Lim; Xiaoling Zhang; Congcong Zhu; So-Yoon Won; Yu Yong Choi; Eun Hyun Seo; Seok Cheol Lee; Jungsoo Gim; Ji Yeon Chung; Ari Chong; Min Soo Byun; Sujin Seo; Pan-Woo Ko; Ji-Won Han; Catriona McLean; John Farrell; Kathryn L Lunetta; Akinori Miyashita; Norikazu Hara; Sungho Won; Seong-Min Choi; Jung-Min Ha; Jee Hyang Jeong; Ryozo Kuwano; Min Kyung Song; Seong Soo A An; Young Min Lee; Kyung Won Park; Ho-Won Lee; Seong Hye Choi; Sangmyung Rhee; Woo Keun Song; Jung Sup Lee; Richard Mayeux; Jonathan L Haines; Margaret A Pericak-Vance; I L Han Choo; Kwangsik Nho; Ki-Woong Kim; Dong Young Lee; SangYun Kim; Byeong C Kim; Hoowon Kim; Gyungah R Jun; Gerard D Schellenberg; Takeshi Ikeuchi; Lindsay A Farrer; Kun Ho Lee; Alzheimer's Disease Neuroimaging Initative Journal: J Clin Med Date: 2019-08-16 Impact factor: 4.241
Authors: Sharmin Hossain; May A Beydoun; Marie F Kuczmarski; Salman Tajuddin; Michele K Evans; Alan B Zonderman Journal: Nutrients Date: 2019-09-11 Impact factor: 5.717
Authors: Sharmin Hossain; Michele K Evans; Alan B Zonderman; May A Beydoun; Jordan Weiss; Marie F Kuczmarski Journal: Br J Nutr Date: 2020-04-06 Impact factor: 3.718