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Literature DB >> 26823897

Metaplastic thymoma with myasthenia gravis presumably caused by an accumulation of intratumoral immature T cells: a case report.

Shogo Tajima¹, Masahiro Yanagiya², Masaaki Sato², Jun Nakajima², Masashi Fukayama¹.

Abstract

Among human neoplasms, thymomas are well known for their association with paraneoplastic autoimmune diseases such as myasthenia gravis. However, regarding rare metaplastic thymoma, only one case of an association with myasthenia gravis has been reported. Here, we present the second case of a 44-year-old woman with metaplastic thymoma associated with myasthenia gravis. In metaplastic thymoma, intratumoral terminal deoxynucleotidyl transferase-positive T-cells (immature T-cells) are generally scarce, while they were abundant in the present case. We believe that these immature T-cells could be related to the occurrence of myasthenia gravis.

Entities: Disease Species

Keywords: Histology; immature T-cells; immunohistochemistry; metaplastic thymoma; myasthenia gravis

Mesh：

Substances：

Year: 2015 PMID： 26823897 PMCID： PMC4713683

Source DB: PubMed Journal: Int J Clin Exp Pathol ISSN： 1936-2625

19 in total

1. Introduction to The 2015 World Health Organization Classification of Tumors of the Lung, Pleura, Thymus, and Heart.

Authors: William D Travis; Elisabeth Brambilla; Allen P Burke; Alexander Marx; Andrew G Nicholson
Journal: J Thorac Oncol Date: 2015-09 Impact factor: 15.609

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Authors: N Sommer; N Willcox; G C Harcourt; J Newsom-Davis
Journal: Ann Neurol Date: 1990-09 Impact factor: 10.422

4. Neurofilament is an autoantigenic determinant in myasthenia gravis.

Authors: A Schultz; V Hoffacker; A Wilisch; W Nix; R Gold; B Schalke; S Tzartos; H K Müller-Hermelink; A Marx
Journal: Ann Neurol Date: 1999-08 Impact factor: 10.422

Review 5. From basic immunobiology to the upcoming WHO-classification of tumors of the thymus. The Second Conference on Biological and Clinical Aspects of Thymic Epithelial Tumors and related recent developments.

Authors: A Marx; H K Müller-Hermelink
Journal: Pathol Res Pract Date: 1999 Impact factor: 3.250

Review 6. The role of T-cells in the initiation of autoantibody responses in thymoma patients.

Authors: A Vincent; N Willcox
Journal: Pathol Res Pract Date: 1999 Impact factor: 3.250

7. Type AB thymoma is not a mixed tumor of type A and type B thymomas, but a distinct type of thymoma.

Authors: Yukari Miki; Kana Hamada; Tadashi Yoshino; Katsuya Miyatani; Kiyoshi Takahashi
Journal: Virchows Arch Date: 2014-05-07 Impact factor: 4.064

8. Neoplastic thymic epithelial cells of human thymoma support T cell development from CD4-CD8- cells to CD4+CD8+ cells in vitro.

Authors: M Inoue; Y Fujii; M Okumura; Y Takeuchi; H Shiono; S Miyoshi; H Matsuda; R Shirakura
Journal: Clin Exp Immunol Date: 1998-06 Impact factor: 4.330

Metaplastic thymoma with myasthenia gravis presumably caused by an accumulation of intratumoral immature T cells: a case report.

1. Introduction to The 2015 World Health Organization Classification of Tumors of the Lung, Pleura, Thymus, and Heart.

2. Immunological heterogeneity and cellular mechanisms in myasthenia gravis.

3. Myasthenic thymus and thymoma are selectively enriched in acetylcholine receptor-reactive T cells.

4. Neurofilament is an autoantigenic determinant in myasthenia gravis.

Review 5. From basic immunobiology to the upcoming WHO-classification of tumors of the thymus. The Second Conference on Biological and Clinical Aspects of Thymic Epithelial Tumors and related recent developments.

Review 6. The role of T-cells in the initiation of autoantibody responses in thymoma patients.

7. Type AB thymoma is not a mixed tumor of type A and type B thymomas, but a distinct type of thymoma.

8. Neoplastic thymic epithelial cells of human thymoma support T cell development from CD4-CD8- cells to CD4+CD8+ cells in vitro.

9. Abnormal thymocyte development and generation of autoreactive T cells in mixed and cortical thymomas.

10. Immaturity of lymphocytes in the metastatic lesions of thymoma.

1. Metaplastic thymoma: a distinctive thymic neoplasm characterized by YAP1-MAML2 gene fusions.

2. YAP1-MAML2 Fusion as a Diagnostic Biomarker for Metaplastic Thymoma.