Gang Zhou1, Ying Wang2, Ziyao Fang1, Rongrong Liu1, Anhui Wang3, Feng Zhao4, Lihua Chen1. 1. Department of Immunology, Fourth Military Medical University Xi'an, China. 2. Department of Immunology, Fourth Military Medical UniversityXi'an, China; Department of Stomatology, Affiliated Hospital of Academy of Military Medical SciencesBeijing, China. 3. Department of Preventive Medicine and Health Statistics, Fourth Military Medical University Xi'an, China. 4. Department of Respiratory Medicine, Xijing Hospital, Fourth Military Medical University Xi'an, China.
Abstract
BACKGROUND: The co-stimulatory molecule CD40 plays an important role in anti-tumor responses by promoting cytotoxic T lymphocyte (CTL) activity and differentiation of helper T cells. Growing evidence suggests that single nucleotide polymorphisms (SNPs) in CD40 are associated with the susceptibility to cancer. This study investigated the association between the CD40 -1C/T SNP (rs1883832) and lung cancer in a Chinese population. METHODS: We conducted a hospital-based case-control study including 105 lung cancer patients and 109 healthy control subjects. The -1C/T SNP in CD40 was genotyped by the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP), and its association with lung cancer susceptibility was evaluated. RESULTS: The distribution of the genotypes of CD40-1C/T was significantly different between lung cancer patients and controls. The frequency of the TT genotype (adjusted P = 0.017; overall risk [OR] = 2.94; 95% confidence interval [CI] = 1.21-7.13) and TT/CT genotype (adjusted P = 0.020; OR = 1.95; 95% CI = 1.11-3.43) were significantly higher in lung cancer patients than that in controls. When the cases were categorized by tumor histology, the TT genotype was associated with a significantly increased risk of squamous cell carcinoma (adjusted OR = 6.53; 95% CI = 1.97-21.61; P = 0.002). CONCLUSION: Our findings suggest that the CD40 -1C/T SNP (rs1883832) is correlated with the susceptibility to lung cancer in Chinese, and the TT genotype may further increase the risk of lung cancer.
BACKGROUND: The co-stimulatory molecule CD40 plays an important role in anti-tumor responses by promoting cytotoxic T lymphocyte (CTL) activity and differentiation of helper T cells. Growing evidence suggests that single nucleotide polymorphisms (SNPs) in CD40 are associated with the susceptibility to cancer. This study investigated the association between the CD40 -1C/T SNP (rs1883832) and lung cancer in a Chinese population. METHODS: We conducted a hospital-based case-control study including 105 lung cancerpatients and 109 healthy control subjects. The -1C/T SNP in CD40 was genotyped by the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP), and its association with lung cancer susceptibility was evaluated. RESULTS: The distribution of the genotypes of CD40-1C/T was significantly different between lung cancerpatients and controls. The frequency of the TT genotype (adjusted P = 0.017; overall risk [OR] = 2.94; 95% confidence interval [CI] = 1.21-7.13) and TT/CT genotype (adjusted P = 0.020; OR = 1.95; 95% CI = 1.11-3.43) were significantly higher in lung cancerpatients than that in controls. When the cases were categorized by tumor histology, the TT genotype was associated with a significantly increased risk of squamous cell carcinoma (adjusted OR = 6.53; 95% CI = 1.97-21.61; P = 0.002). CONCLUSION: Our findings suggest that the CD40 -1C/T SNP (rs1883832) is correlated with the susceptibility to lung cancer in Chinese, and the TT genotype may further increase the risk of lung cancer.
Entities:
Keywords:
CD40; lung cancer; single nucleotide polymorphism
Authors: Ju Hyun Park; Hun Soo Chang; Choon-Sik Park; An-Soo Jang; Byung Lae Park; Tai Youn Rhim; Soo-Taek Uh; Yong Hoon Kim; Il Yup Chung; Hyung Doo Shin Journal: Am J Respir Crit Care Med Date: 2007-01-25 Impact factor: 21.405
Authors: Anand Pathak; Angela S Wenzlaff; Paula L Hyland; Michele L Cote; Greg R Keele; Susan Land; Matthew L Boulton; Ann G Schwartz Journal: J Cancer Ther Res Date: 2014
Authors: Christine F Skibola; Alexandra Nieters; Paige M Bracci; John D Curry; Luz Agana; Danica R Skibola; Alan Hubbard; Nikolaus Becker; Martyn T Smith; Elizabeth A Holly Journal: Blood Date: 2008-02-20 Impact factor: 22.113
Authors: Soumya Raychaudhuri; Elaine F Remmers; Annette T Lee; Rachel Hackett; Candace Guiducci; Noël P Burtt; Lauren Gianniny; Benjamin D Korman; Leonid Padyukov; Fina A S Kurreeman; Monica Chang; Joseph J Catanese; Bo Ding; Sandra Wong; Annette H M van der Helm-van Mil; Benjamin M Neale; Jonathan Coblyn; Jing Cui; Paul P Tak; Gert Jan Wolbink; J Bart A Crusius; Irene E van der Horst-Bruinsma; Lindsey A Criswell; Christopher I Amos; Michael F Seldin; Daniel L Kastner; Kristin G Ardlie; Lars Alfredsson; Karen H Costenbader; David Altshuler; Tom W J Huizinga; Nancy A Shadick; Michael E Weinblatt; Niek de Vries; Jane Worthington; Mark Seielstad; Rene E M Toes; Elizabeth W Karlson; Ann B Begovich; Lars Klareskog; Peter K Gregersen; Mark J Daly; Robert M Plenge Journal: Nat Genet Date: 2008-09-14 Impact factor: 38.330
Authors: Foteinos-Ioannis D Dimitrakopoulos; Anna G Antonacopoulou; Anastasia E Kottorou; Melpomeni Kalofonou; Nikolaos Panagopoulos; Dimitrios Dougenis; Thomas Makatsoris; Vasiliki Tzelepi; Angelos Koutras; Haralabos P Kalofonos Journal: Front Oncol Date: 2021-09-17 Impact factor: 6.244