Literature DB >> 2682385

Demonstration of GABAergic cell bodies in the suprachiasmatic nucleus: in situ hybridization of glutamic acid decarboxylase (GAD) mRNA and immunocytochemistry of GAD and GABA.

H Okamura1, A Bérod, J F Julien, M Geffard, K Kitahama, J Mallet, P Bobillier.   

Abstract

The existence of GABAergic neurons in the rat suprachiasmatic nucleus (SCN) was demonstrated by three specific markers; mRNA coding for glutamic acid decarboxylase (GAD) and visualized by in situ hybridization using a 35S-labelled cDNA probe, and GAD protein and GABA were identified by immunocytochemistry using specific antisera. In situ hybridization demonstrated well labelled GAD mRNA positive cells throughout SCN, and GABA and GAD immunoreactive cells showed similar distributions. These results indicate that GABA is a transmitter of a large portion of the SCN neuronal population.

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Year:  1989        PMID： 2682385     DOI： 10.1016/0304-3940(89)90067-0

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  26 in total

1.  Activation of NMDA receptors in the suprachiasmatic nucleus produces light-like phase shifts of the circadian clock in vivo.

Authors:  E M Mintz; C L Marvel; C F Gillespie; K M Price; H E Albers
Journal:  J Neurosci       Date:  1999-06-15       Impact factor: 6.167

2.  Fractal stochastic modeling of spiking activity in suprachiasmatic nucleus neurons.

Authors:  Sung-Il Kim; Jaeseung Jeong; Yongho Kwak; Yang In Kim; Seung Hun Jung; Kyoung J Lee
Journal:  J Comput Neurosci       Date:  2005-08       Impact factor: 1.621

3.  Intracellular electrophysiological study of suprachiasmatic nucleus neurons in rodents: inhibitory synaptic mechanisms.

Authors:  Y I Kim; F E Dudek
Journal:  J Physiol       Date:  1992-12       Impact factor: 5.182

4.  Multiple NPY receptors coexist in pre- and postsynaptic sites: inhibition of GABA release in isolated self-innervating SCN neurons.

Authors:  G Chen; A N van den Pol
Journal:  J Neurosci       Date:  1996-12-01       Impact factor: 6.167

Review 5.  The rhythmic GABAergic system.

Authors:  D P Cardinali; D A Golombek
Journal:  Neurochem Res       Date:  1998-05       Impact factor: 3.996

Review 6.  Circadian dysfunction may be a key component of the non-motor symptoms of Parkinson's disease: insights from a transgenic mouse model.

Authors:  L David Willison; Takashi Kudo; Dawn H Loh; Dika Kuljis; Christopher S Colwell
Journal:  Exp Neurol       Date:  2013-01-24       Impact factor: 5.330

Review 7.  Collective timekeeping among cells of the master circadian clock.

Authors:  Jennifer A Evans
Journal:  J Endocrinol       Date:  2016-05-06       Impact factor: 4.286

8.  Dynamical heterogeneity of suprachiasmatic nucleus neurons based on regularity and determinism.

Authors:  Jaeseung Jeong; Yongho Kwak; Yang In Kim; Kyoung J Lee
Journal:  J Comput Neurosci       Date:  2005-08       Impact factor: 1.621

9.  GABA and glutamate mediate rapid neurotransmission from suprachiasmatic nucleus to hypothalamic paraventricular nucleus in rat.

Authors:  M L Hermes; E M Coderre; R M Buijs; L P Renaud
Journal:  J Physiol       Date:  1996-11-01       Impact factor: 5.182

10.  Pituitary adenylate cyclase-activating polypeptide and melatonin in the suprachiasmatic nucleus: effects on the calcium signal transduction cascade.

Authors:  M D Kopp; C Schomerus; F Dehghani; H W Korf; H Meissl
Journal:  J Neurosci       Date:  1999-01-01       Impact factor: 6.167
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