Jiaying Ruan1, Ling Mei1, Qian Zhu1, Gang Shi1, He Wang1. 1. Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University Renmin South Road, Chengdu 610041, China.
Abstract
BACKGROUND: The mixed lineage kinase domain-like protein (MLKL) has recently been identified as a key RIP3 (receptor interacting protein 3) downstream component of tumor necrosis factor (TNF)-induced necroptosis. OBJECTIVE: To evaluate the expression and clinical significance of MLKL in cervical squamous cell carcinoma. METHODS: The expression of MLKL in 54 cervical squamous carcinoma samples was detected by immuneohistochemical method. Chi-square, correlation analysis and kaplan-Meier method were used to analyze the data. RESULTS: The MLKL expression in cervical squamous cell carcinoma was higher than that in normal cervical tissues (P = 0.004). The MLKL expression was negatively correlated with histological grade, lymphatic metastasis (P<0.05). Survival analysis showed the low expression of MLKL indicated poor prognosis. CONCLUSION: MLKL was a prognostic biomarker for cervical squamous cell carcinoma.
BACKGROUND: The mixed lineage kinase domain-like protein (MLKL) has recently been identified as a key RIP3 (receptor interacting protein 3) downstream component of tumor necrosis factor (TNF)-induced necroptosis. OBJECTIVE: To evaluate the expression and clinical significance of MLKL in cervical squamous cell carcinoma. METHODS: The expression of MLKL in 54 cervical squamous carcinoma samples was detected by immuneohistochemical method. Chi-square, correlation analysis and kaplan-Meier method were used to analyze the data. RESULTS: The MLKL expression in cervical squamous cell carcinoma was higher than that in normal cervical tissues (P = 0.004). The MLKL expression was negatively correlated with histological grade, lymphatic metastasis (P<0.05). Survival analysis showed the low expression of MLKL indicated poor prognosis. CONCLUSION:MLKL was a prognostic biomarker for cervical squamous cell carcinoma.
Authors: Jie Zhao; Siriporn Jitkaew; Zhenyu Cai; Swati Choksi; Qiuning Li; Ji Luo; Zheng-Gang Liu Journal: Proc Natl Acad Sci U S A Date: 2012-03-15 Impact factor: 11.205
Authors: Linde Duprez; Nozomi Takahashi; Filip Van Hauwermeiren; Benjamin Vandendriessche; Vera Goossens; Tom Vanden Berghe; Wim Declercq; Claude Libert; Anje Cauwels; Peter Vandenabeele Journal: Immunity Date: 2011-12-23 Impact factor: 31.745
Authors: Bo Yang; Lili Fu; Jamie R Privratsky; Xiaohan Lu; Jiafa Ren; Changlin Mei; Steven D Crowley Journal: Am J Physiol Renal Physiol Date: 2019-05-29
Authors: Swapna A Gudipaty; Christopher M Conner; Jody Rosenblatt; Denise J Montell Journal: Annu Rev Cell Dev Biol Date: 2018-08-08 Impact factor: 13.827