Literature DB >> 26823836

Relationship between CIP2A expression, and prognosis and MDR-related proteins in patients with advanced gastric cancer.

Jian-Shi Chen1, Bin-Bin Wu2, Hai-Li Bao3, Ji-Mei Du4, Sheng-Chu Zhang5, Yi-Hu Zheng3.   

Abstract

CIP2A is highly expressed in a variety of malignancies. We determined the expression and clinical significance of CIP2A in patients with advanced gastric cancer. CIP2A protein was expressed in 25 of 37 cancer tissue specimens. There was no correlation between CIP2A and PGP, GST-π, Topo-II, and LRP expression. Survival analysis showed significant differences between the survival rate of the CIP2A protein-positive and -negative groups (χ(2)=4.509, P=0.034), but the degree of positive expression was unrelated to survival time (χ(2)=4.639, P=0.098). CIP2A expression may have no prospective value for optimizing chemotherapy regimens, but it can be an indicator for patient prognosis.

Entities:  

Keywords:  CIP2A; Gastric cancer; Helicobacter pylori; MRD; p53; survival time

Mesh：

Substances：

Year:  2015        PMID： 26823836      PMCID： PMC4713622     

Source DB:  PubMed          Journal:  Int J Clin Exp Pathol        ISSN： 1936-2625


  19 in total

1.  Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world.

Authors:  Farin Kamangar; Graça M Dores; William F Anderson
Journal:  J Clin Oncol       Date:  2006-05-10       Impact factor: 44.544

Review 2.  Fluoxetine and reversal of multidrug resistance.

Authors:  Dan Peer; Rimona Margalit
Journal:  Cancer Lett       Date:  2005-07-12       Impact factor: 8.679

3.  Global cancer statistics, 2002.

Authors:  D Max Parkin; Freddie Bray; J Ferlay; Paola Pisani
Journal:  CA Cancer J Clin       Date:  2005 Mar-Apr       Impact factor: 508.702

Review 4.  Incidence and mortality of gastric cancer in China.

Authors:  Ling Yang
Journal:  World J Gastroenterol       Date:  2006-01-07       Impact factor: 5.742

5.  Protein phosphatase 2A regulatory subunit B56alpha associates with c-myc and negatively regulates c-myc accumulation.

Authors:  Hugh K Arnold; Rosalie C Sears
Journal:  Mol Cell Biol       Date:  2006-04       Impact factor: 4.272

6.  Induction of differentiation in HL60 cells by the reduction of extrachromosomally amplified c-myc.

Authors:  S G Eckhardt; A Dai; K K Davidson; B J Forseth; G M Wahl; D D Von Hoff
Journal:  Proc Natl Acad Sci U S A       Date:  1994-07-05       Impact factor: 11.205

7.  MYC-dependent regulation and prognostic role of CIP2A in gastric cancer.

Authors:  Anchit Khanna; Camilla Böckelman; Annabrita Hemmes; Melissa R Junttila; Jan-Patrik Wiksten; Mikael Lundin; Siina Junnila; Daniel J Murphy; Gerard I Evan; Caj Haglund; Jukka Westermarck; Ari Ristimäki
Journal:  J Natl Cancer Inst       Date:  2009-05-26       Impact factor: 13.506

8.  CIP2A is associated with human breast cancer aggressivity.

Authors:  Christophe Côme; Anni Laine; Maïa Chanrion; Henrik Edgren; Elina Mattila; Xiaoling Liu; Jos Jonkers; Johanna Ivaska; Jorma Isola; Jean-Marie Darbon; Olli Kallioniemi; Simon Thézenas; Jukka Westermarck
Journal:  Clin Cancer Res       Date:  2009-08-11       Impact factor: 12.531

9.  CIP2A inhibits PP2A in human malignancies.

Authors:  Melissa R Junttila; Pietri Puustinen; Minna Niemelä; Raija Ahola; Hugh Arnold; Trine Böttzauw; Risto Ala-aho; Christina Nielsen; Johanna Ivaska; Yoichi Taya; Shi-Long Lu; Shujun Lin; Edward K L Chan; Xiao-Jing Wang; Reidar Grènman; Juergen Kast; Tuula Kallunki; Rosalie Sears; Veli-Matti Kähäri; Jukka Westermarck
Journal:  Cell       Date:  2007-07-13       Impact factor: 41.582

Review 10.  Mechanisms of MYC stabilization in human malignancies.

Authors:  Melissa R Junttila; Jukka Westermarck
Journal:  Cell Cycle       Date:  2007-12-29       Impact factor: 4.534
View more
  3 in total

1.  BBOX1-AS1 Accelerates Gastric Cancer Proliferation by Sponging miR-3940-3p to Upregulate BIRC5 Expression.

Authors:  Yan Yang; Qiong Yu; Bing Li; Renzhen Guan; ChangYong Huang; XiuCheng Yang
Journal:  Dig Dis Sci       Date:  2020-05-11       Impact factor: 3.199

2.  Knockdown of long non-coding RNA ANRIL inhibits tumorigenesis in human gastric cancer cells via microRNA-99a-mediated down-regulation of BMI1.

Authors:  Pei Liu; Mingming Zhang; Qinghui Niu; Fengjuan Zhang; Yuling Yang; Xiangjun Jiang
Journal:  Braz J Med Biol Res       Date:  2018-08-16       Impact factor: 2.590

3.  Prognostic significance of CIP2A expression in solid tumors: A meta-analysis.

Authors:  Min Tang; Jiao-Feng Shen; Ping Li; Li-Na Zhou; Ping Zeng; Xi-Xi Cui; Min-Bin Chen; Ye Tian
Journal:  PLoS One       Date:  2018-07-25       Impact factor: 3.240
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.