| Literature DB >> 26823560 |
Isadora L Flores1, Rebeca Kawahara2, Márcia C C Miguel3, Daniela C Granato2, Romênia R Domingues2, Carolina C S Macedo1, Carolina M Carnielli2, Sami Yokoo2, Priscila C Rodrigues4, Bárbara V B Monteiro3, Carine E Oliveira4, Cristiane R Salmon5, Francisco H Nociti5, Márcio A Lopes4, Alan Santos-Silva4, Flavia V Winck2, Ricardo D Coletta6, Adriana F Paes Leme7.
Abstract
EEF1D (eukaryotic translation elongation factor 1δ) is a subunit of the elongation factor 1 complex of proteins that mediates the elongation process during protein synthesis via enzymatic delivery of aminoacyl-tRNAs to the ribosome. Although the functions of EEF1D in the translation process are recognized, EEF1D expression was found to be unbalanced in tumours. In the present study, we demonstrate the overexpression of EEF1D in OSCC (oral squamous cell carcinoma), and revealed that EEF1D and protein interaction partners promote the activation of cyclin D1 and vimentin proteins. EEF1D knockdown in OSCC reduced cell proliferation and induced EMT (epithelial-mesenchymal transition) phenotypes, including cell invasion. Taken together, these results define EEF1D as a critical inducer of OSCC proliferation and EMT.Entities:
Keywords: epithelial–mesenchymal transition; eukaryotic translation elongation factor 1δ; oral cancer
Mesh：
Substances：
Year: 2016 PMID： 26823560 DOI： 10.1042/CS20150646
Source DB: PubMed Journal: Clin Sci (Lond) ISSN： 0143-5221 Impact factor: 6.124