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Literature DB >> 2682265

Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish.

J R Kelsoe¹, E I Ginns, J A Egeland, D S Gerhard, A M Goldstein, S J Bale, D L Pauls, R T Long, K K Kidd, G Conte.

Abstract

Reanalysis of an Old Order Amish pedigree, to include several new individuals and two changes in clinical status, markedly reduces the probability of linkage between bipolar affective disorder and the Harvey-ras-1 oncogene and insulin loci on chromosome 11. This linkage can be excluded using a large lateral extension of the original Amish pedigree.

Entities: Disease Gene

Mesh：

Substances：
Insulin

Year: 1989 PMID： 2682265 DOI： 10.1038/342238a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

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Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish.

1. Genetic optimism: framing genes and mental illness in the news.

2. An association between manic-depressive illness and a pseudoautosomal DNA marker.

3. Inter- and intrafamilial heterogeneity: effective sampling strategies and comparison of analysis methods.

4. Gene-environment interplay in affect and dementia: emotional modulation of cognitive expression in personal outcomes.

5. Computer simulation of linkage and heterogeneity in tuberous sclerosis: a critical evaluation of the collaborative family data.

Review 6. Genetics and genomics of psychiatric disease.

7. Genetic linkage analysis of bipolar affective disorder in an Old Order Amish pedigree.

8. Sensitivity of lod scores to changes in diagnostic status.

9. The strange malady of Alessandro's uncle.

Review 10. Amish revisited: next-generation sequencing studies of psychiatric disorders among the Plain people.