Seema Garg1, Stuti Gupta2, Md Salamtullah Mobeen3, Sri Venkata Madhu4. 1. Department of Biochemistry, University College of Medical Sciences, University of Delhi, India. Electronic address: seegarg@yahoo.com. 2. Department of Biochemistry, University College of Medical Sciences, University of Delhi, India. Electronic address: guptastuti83@gmail.com. 3. University College of Medical Sciences, University of Delhi, India. Electronic address: salamatullahmobeen@yahoo.com. 4. Department of Medicine, University College of Medical Sciences, University of Delhi, India. Electronic address: drsvmadhu@gmail.com.
Abstract
AIMS: Tissue hypoxia is an important contributor to diabetic complications. Glycation of hemoglobin (Hb) and obesity are major determinant of oxygen saturation (SpO2) in blood. Hence, the present study was planned to evaluate the effect of obesity on SpO2 in a wide range of glycated hemoglobin (HbA1c) levels in ambulatory type 2 diabetic patients. MATERIAL AND METHODS: A cohort of 60 subjects irrespective of diabetic status were recruited and clustered in group I (HbA1c <6.5) and group II (HbA1c ≥6.5) depending on HbA1c. Anthropometry and routine biochemical parameters were measured. HbA1c (%) were estimated by high performance liquid chromatography (HPLC) respectively. SpO2 (%) levels were measured by pulse oximetry. Pearson correlation, bivariate regression and student 't' test were used for statistical analysis. RESULTS: Blood concentration of HbA1c was <6.5 in 29 participants and ≥6.5 in 31 participants. Plasma fasting and post prandial glucose, HbA1c as well as Hb levels were significantly (p<0.50) higher in diabetics as compared to non diabetics. Waist circumference (WC) (r=-400; p=0.026) and body mass index (BMI) (r=-381; p=0.034) showed a significant negative correlation with SpO2 in diabetic patients. On adjusting HbA1c in group II, SpO2 was found to independently and inversely associated with WC (p=0.042) and BMI (p=0.049). CONCLUSIONS: Obesity was found to be a strong independent contributor to reduction in oxygen carrying capacity in ambulatory type 2 diabetic subjects. However there is no effect of glycated Hb on SpO2 in the same population.
AIMS: Tissue hypoxia is an important contributor to diabetic complications. Glycation of hemoglobin (Hb) and obesity are major determinant of oxygen saturation (SpO2) in blood. Hence, the present study was planned to evaluate the effect of obesity on SpO2 in a wide range of glycated hemoglobin (HbA1c) levels in ambulatory type 2 diabeticpatients. MATERIAL AND METHODS: A cohort of 60 subjects irrespective of diabetic status were recruited and clustered in group I (HbA1c <6.5) and group II (HbA1c ≥6.5) depending on HbA1c. Anthropometry and routine biochemical parameters were measured. HbA1c (%) were estimated by high performance liquid chromatography (HPLC) respectively. SpO2 (%) levels were measured by pulse oximetry. Pearson correlation, bivariate regression and student 't' test were used for statistical analysis. RESULTS: Blood concentration of HbA1c was <6.5 in 29 participants and ≥6.5 in 31 participants. Plasma fasting and post prandial glucose, HbA1c as well as Hb levels were significantly (p<0.50) higher in diabetics as compared to non diabetics. Waist circumference (WC) (r=-400; p=0.026) and body mass index (BMI) (r=-381; p=0.034) showed a significant negative correlation with SpO2 in diabeticpatients. On adjusting HbA1c in group II, SpO2 was found to independently and inversely associated with WC (p=0.042) and BMI (p=0.049). CONCLUSIONS:Obesity was found to be a strong independent contributor to reduction in oxygen carrying capacity in ambulatory type 2 diabetic subjects. However there is no effect of glycated Hb on SpO2 in the same population.