| Literature DB >> 26822317 |
Paolo Bernasconi1, Mirko Farina1, Marina Boni1, Irene Dambruoso1, Celeste Calvello1.
Abstract
A tight relationship between the acute myeloid leukemia (AML) population and the bone marrow (BM) microenvironment has been convincingly established. The AML clone contains leukemic stem cells (LSCs) that compete with normal hematopoietic stem cells (HSCs) for niche occupancy and remodel the niche; whereas, the BM microenvironment might promote AML development and progression not only through hypoxia and homing/adhesion molecules, but also through genetic defects. Although it is still unknown whether the niche influences treatment results or contains any potential target for treatment, this dynamic AML-niche interaction might be a promising therapeutic objective to significantly improve the AML cure rate.Entities:
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Year: 2016 PMID： 26822317 DOI： 10.1002/ajh.24312
Source DB: PubMed Journal: Am J Hematol ISSN： 0361-8609 Impact factor: 10.047