Literature DB >> 26821952

Weak signal detection: A discrete window of opportunity for achieving 'Vision 90:90:90'?

Christopher J Burman1, Marota Aphane2, Peter Delobelle3.   

Abstract

INTRODUCTION: UNAIDS' Vision 90:90:90 is a call to 'end AIDS'. Developing predictive foresight of the unpredictable changes that this journey will entail could contribute to the ambition of 'ending AIDS'. There are few opportunities for managing unpredictable changes. We introduce 'weak signal detection' as a potential opportunity to fill this void.
METHOD: Combining futures and complexity theory, we reflect on two pilot case studies that involved the Archetype Extraction technique and the SenseMaker(®) Collector(™) tool.
RESULTS: Both the piloted techniques have the potentials to surface weak signals--but there is room for improvement. DISCUSSION: A management response to a complex weak signal requires pattern management, rather than an exclusive focus on behaviour management.
CONCLUSION: Weak signal detection is a window of opportunity to improve resilience to unpredictable changes in the HIV/AIDS landscape that can both reduce the risk that emerges from the changes and increase the visibility of opportunities to exploit the unpredictable changes that could contribute to 'ending AIDS'.

Entities:  

Keywords:  Cynefin framework; HIV/AIDS; VIH/SIDA; autopoiesis; complexity theory; futures science; sciences des futures; théorie de la complexité

Mesh:

Year:  2016        PMID: 26821952      PMCID: PMC5642432          DOI: 10.1080/17290376.2015.1123642

Source DB:  PubMed          Journal:  SAHARA J        ISSN: 1729-0376


Introduction

In 2014, UNAIDS produced two hard-hitting reports that focus on ‘ending AIDS’. One of the reports – The Gap Report – asks the question: ‘How do we close the gap between the people moving forward and the people being left behind?’ and then says: ‘We have a fragile five-year window [2015-2020] to build on the rapid results that have been made. The next five years will determine the next 15 [of the trajectory of the epidemic]’ (UNAIDS 2014b:iv–v). The other report – Fast Track – reinforces these points before providing a global overview of what has been achieved – and what is required – to ‘end AIDS’. The overarching ambition, which was agreed at the International AIDS Conference in Australia, 2014, is known as ‘Vision 90:90:90’ (UNAIDS 2014a:iii), which means ‘90% of people know their status; 90% of those that are HIV positive are on treatment; 90% of those on treatment are virally suppressed’ (Motsoaledi 2014). The reason for this re-orientation is that it has been predicted that ‘without scale-up [to 90:90:90], the AIDS epidemic will continue to outrun the response, increasing the long-term need for HIV treatment and increasing future costs’ (UNAIDS 2014a:4). The South African National Department of Health (NDoH) has embarked on an expanded combination prevention approach as a contribution to achieving the global ambition of ‘ending AIDS’. Combination strategies that fit local contexts is now the sine qua non of HIV prevention because ‘[biomedical] HIV programmes are dramatically strengthened when they are combined with social and structural approaches’ (UNAIDS 2014a:6; also see Hankins and de Zalduondo 2010). In South Africa, the Vision 90:90:90 ambition means a significant scale up of existing measures being taken to reduce the aggregate national viral load that is inclusive of treatment, behavioural, structural and educational measures (Motsoaledi 2014). This initiative is extremely welcome, but one that we suggest will be fraught with implementation challenges as the South African healthcare system rolls out these different, inter-related initiatives within such a compressed – ‘five year’ – time-frame. We will argue that the concept of ‘weak signal detection’ can add value to the management of the next five years of the HIV/AIDS landscape because Vision 90:90:90 requires accelerated combination interventions and a social transformation in the uptake of these opportunities. In order to make this argument, we will explore the notion of weak signal detection before reflecting on our own – albeit localised and imperfect – experiences of piloting weak signal detection. Our own experiences revealed that while weak signal detection efforts can add value to working in localised contexts, the methods are sometimes imprecise and demanding – as other commentators have noted (Rossel 2012). Despite these challenges, we will argue that there is both practical and strategic utility in improving the techniques and applying the approach at different scales as a contribution to achieving Vision 90:90:90. The conceptual foundations of the article are represented in Fig. 1.
Fig. 1.

The conceptual foundations. Source: authors’ contribution.

The conceptual foundations. Source: authors’ contribution. The theoretical framework is influenced by concepts transposed from complexity theory and futures science and, through this kaleidoscope, we will argue that the approach can contribute to achieving Vision 90:90:90 by building national resilience in the form of both anticipatory surveillance capacity and an adaptive response capacity. We will also suggest that it is possible to strategically align these processes to the NDoH's eHealth vision of facilitating ‘real-time information for decision-making’ (NDoH 2012:5).

Dynamic adaptive landscapes

As has been noted above, UNAIDS is calling for a seismic shift so that the possibility of ‘ending AIDS’ by 2030 becomes a reality. In the last 30 years of the epidemic, there have been macro-, meso- and micro-changes in the epidemiological landscape and, as with many epidemics (Galea, Riddle & Kaplan 2010), the complexity of these processes has been confounding (Stillwaggon 2012). Despite a call that was made almost a decade ago to embrace these complexities (Piot, Bartos, Larson, Zewdie & Mane 2008), the HIV/AIDS landscape continues to be one that is turbulent and difficult to negotiate. It is logical to begin our discussion from the premise that we cannot expect the next five years to be less turbulent – which is why UNAIDS warns that a complacent ‘business as usual’ approach (UNAIDS 2014b:242) risks the ‘epidemic springing back even stronger’ (2014a:iii).

A dynamic South African AIDS landscape

Many of the changes in the South African HIV/AIDS landscape have been triggered by the NDoH's – and other organisations' – efforts to address the epidemic. Significant results are now occurring across the nation (Shisana et al. 2014) – yet unexpected changes have also occurred: for example, ‘overall condom use at last sex increased significantly from 2002 to 2008 and then significantly decreased in 2012 among all three age groups and for both sexes except among females aged 50 years and older’ (Shisana et al. 2014:xxxiv). This type of unexpected change undermines the NDoH's plans for reducing the aggregate national viral load – making this unpredictable component of the landscape relevant if Vision 90:90:90 is to be achieved. Not only is the HIV/AIDS landscape influenced by the way in which interventions intersect with local communities and the way in which communities – and the localised ‘sensori-memorabilia’ within those communities (Burman, Mamabolo, Aphane, Lebese & Delobelle 2013:22) – respond to interventions; it is also influenced by other dynamic networks such as migration (Lurie & Williams 2014), drug resistance (Rossouw 2014) and interconnected chronic health challenges (Deeks, Lewin & Havlir 2013). We therefore suggest that it is logical to conceptualise the landscape as being a complex, adaptive epidemiological landscape and the implications of this claim are explored below.

HIV/AIDS and complexity theory

Increasingly, direct and indirect links are being made between healthcare and complexity (Carey & Crammond 2015; Jayasinghe 2011; Martin, Grady, Deaconking, McMahon, Zarabzadeh, & O'Shea 2011). Complexity theory is an integrated and interdisciplinary perspective that views both natural and social phenomena as dynamic, interactive, patterned, yet sometimes unpredictable, and interconnected relational processes contained within a system of interest (Stacey 1996) – with ‘complexity’ referring ‘to the nature of the problem not the degree of difficulty’ (Stirzaker, Biggs, Roux & Cilliers 2010:600). Typically, complexity is situated in a system known as a complex adaptive system – which has been summarised in the following way (Table 1).
Table 1.

Complex Adaptive Systems.

Agents – People, human processes (rumour, gossip, logical reasoning) and computer systems are examples of agents; the more diverse the agents, the more likely it is that novel behaviour will result from information exchanges (Cilliers 1998; McDaniel & Driebe 2001)
InterconnectionsAgents interact: Agents interact and exchange information through relatively rich means (Cilliers 1998), creating connection among all agents in the system (Capra 2002; Kauffman 2005) Interactions are non-linear means that small ‘causes’ might have large effects and large ‘causes’ might have small effects (Axelrod & Cohen 2000; Capra 2002; Kauffman 2005)
Self-Organisation – is the process by which people mutually adjust their behaviours in ways needed to cope with changing internal and external environmental demands (Cilliers 1998); agents have ‘freedom to interact, align and organize into related configurations’ over time (Lee 1997); thus, agents self-organise (McDaniel & Driebe 2001)
Emergence – ‘Agents interacting in a non-linear fashion may self-organize and cause system properties to emerge’; however, the emergent properties of the whole are distinct from the properties of the agents (Capra 2002; Holland 1998; Johnson 2001)
Co-evolution – Complex adaptive systems are open, and thus agents interact with others in the environment extending the interactions and information exchanges beyond the system boundaries (Boisot & Child 1999; Camazine, Deneubourg, Franks, Sneyd, Theraulaz & Bonabeau 2001; Stacey 1995); both the system and world change through these interactions; the system's current and future behaviour is intricately linked to its history (McDaniel & Driebe 2001)

Source: adapted from Anderson, Crabtree, Steele and McDaniel (2005).

Source: adapted from Anderson, Crabtree, Steele and McDaniel (2005). Table 1 shows that complexity theorisers emphasise processes, relationships and uncertainty rather than relying exclusively on a positivist cause and effect, problem and solution, linear logic enabling an expansive ‘multi-ontology’ perspective (Snowden 2005). Another opportunity provided by complexity is the distinction between ordered and unordered properties of a system (Kurtz & Snowden 2003). Ordered properties of a system are those properties which can be categorised as ones with discernible links to Newtonian ‘cause and effect’. Unordered properties tend to be ones where the ‘cause–effect’ link is indeterminate and causality is only discernible in retrospect.

HIV/AIDS: a complex adaptive epidemiological landscape?

Almost a decade ago, it was argued that it is necessary to work with the complexity of the HIV/AIDS landscape, rather than ignore it. This requires a new set of methodologies and strategies to shift linear models and paradigms to ones that are able to construct ‘analytical tools … to capture these dynamics’ (Piot et al. 2008:853), also see Leach, Scoones and Stirling (2010). Since that time there have been limited – but diverse – responses to the call to apply complexity theory to the HIV/AIDS epidemic (Burman, Aphane & Delobelle 2015; Burman, Aphane, Mtapuri & Delobelle 2015; Burman, Moerschell, Mamabolo, Aphane & Delobelle 2015; Fiorella 2013; Lich, Ginexi, Osgood & Mabry 2013; Silvestri 2013). Situated amongst the call for new tools and methodologies and attempts to articulate responses have been some compelling critiques of HIV/AIDS policies and approaches that ignore these complexities (Nguyen, Bajos, Dubois-Arber, O'Malley & Pirkle 2011; Stillwaggon 2012). For the purposes of developing our argument, we focus on two key concepts drawn from complexity theory – emergence and autopoiesis.

Emergence

Emergence and autopoiesis are key themes that have dominated complexity theory for over half a century (Weaver 1948). Emergence, in this context means ‘when bringing together component parts results in something that simply could not have happened, and situations where, from a human point of view, something novel and surprising appears from a situation that is not even suggestive of this novelty’ (Galatzer-Levy 2002:708). Emergence – as used by complexity theorists – means the phenomena that arise from interactions of systems may either be novel forms of emergence or forms of emergence that are long-term phenomena. Typically, this involves a process when the intersection of new, or existing, systems creates weak interconnections – including feedback – between, or within, system components. Interconnections may at first be random and are thus short-lived, but sometimes the interconnections develop into interdependencies that take on self-sustaining, autopoietic lives of their own – as Weaver (1948:538) hinted at in his conceptualisation of ‘organised complexity’ that ‘involve[s] a sizeable number of factors which are interrelated into an organic whole … .not in a helter skelter fashion [as in disorganised complexity]’ in 1948 (emphasis in original).

Autopoiesis

Autopoiesis is an expression first used in the 1970s to explain the way in which cells self-sustain and self-organise themselves as an adaptive survival mechanism (Maturana & Varela 1980). The expression – not without its detractors (Tastle 1992) – has gradually been incorporated into the lexicon of complexity theory (Cilliers 1998, 2005; Luhmann 1995) and is used to denote the way in which ‘[t]hrough successive repetition a system achieves autopoiesis, a process that transforms itself into itself through recursive closure that is regulated by communication’ (Hatt 2008:320). From recurrent patterned connections, and associated feedback loops, behaviours or phenomena occur that transforms a weakly connected ‘self’ into a qualitatively different – and sustainable – ‘locked-in self’ (Vergne 2013) that moves from a state of unstable interconnections towards a state of stabilised interdependency. Patterned interdependencies create visible, surface descriptors that are outcomes of the relationships amongst different components of a system. These interdependencies result in visible recurrences, such as crowd surging or flocking birds, once they have developed sustainable, interdependent relationships (Ramalingham 2013). Interconnections, on the other hand, only produce short-lived phenomena (Hatt 2008). From the perspective of the HIV/AIDS epidemic, some visible patterns contribute to sustaining the epidemic by enabling the virus to replicate and migrate from one human body to another – such as non-adherence to antiretroviral medication (Stricker et al. 2014) and inconsistent condom use (Shisana et al. 2014). Other visible patterns contribute to ‘ending AIDS’ by dampening the ability of the virus to replicate and successfully migrate from one body to another – such as adherence to antiretroviral medication (Rodger, Bruun & Cambiano 2014); consistent and appropriate condom use (Merson, O'Malley, Serwadda & Apisuk 2008) and prevention of mother-to-child transmission in South Africa (Barron et al. 2013). The patterns that enable, or hinder, the ability of the HI virus to replicate – thereby influencing the trajectory of the epidemic – typically involve multiple interactions between different parts of the epidemiological system and the interactions are ‘complex’ because ‘at least some of these components have non-linear relationships between them’ (Stirzaker et al. 2010) (Fig. 2).
Fig. 2.

The virus–human–environment ‘system’ – complex patterned interactions create emergent phenomena associated with HIV/AIDS. Source: Burman, Aphane & Delobelle (2015:16).

The virus–human–environment ‘system’ – complex patterned interactions create emergent phenomena associated with HIV/AIDS. Source: Burman, Aphane & Delobelle (2015:16). Fig. 2 provides a generic representation of the complexity that the epidemic displays. Autopoietic interdependencies and feedback within and between the ‘virus–human–environment system’ produces emergence that sustain the epidemic – and has simultaneously influenced the historical identities of the epidemic. More-often-than-not, responses to the epidemic are triggered by – and respond to – patterned, visible forms of emergence (Table 2).
Table 2.

Phenomena that emerge from within components or between components of the human–virus–environment heuristic.

Emergent phenomena/intervention typologyPrimary relationships/feedback loopsPurpose of interventionExamples of patterns & effectiveness
Biomedical – such as treatment as prevention (TasP)Between the virus–human componentsSuppressing the viral load because an undetectable viral load makes it almost impossible to transmit the virusExample: consistent use of medication once diagnosed HIV+ and a CD4 count of <500
Impact: in the laboratory – very effective (Rodger et al. 2014); in naturalistic, ‘real world’ context – mixed/problematic (Grimsrud, Cornell, Egger, Boulle & Myer 2013; Nguyen et al. 2011) [involves complex interdependencies]
Structural –changing laws or change in social norms/valuesBetween the virus–human–environment componentsDifferent contexts constrain/enable different behaviours enabling decreased/increased health promoting behaviourExample: legalise sex work (Shannon et al. 2014) and same-sex relationships (UNAIDS 2014b) and environmental/co-infections (Modjarrad 2013)
Impact: legal – problematic (UNAIDS 2014b); environmental/co-infections – treating TB/STIs – mixed problematic (Shisana et al. 2014) [involves complex interdependencies]. Managing other co-infections – hardly on the radar screen in RSA (Mkhize-Kwitshana & Mabaso 2014)
Behavioural – barriers to transmission of the virus, such as condoms or microbicidesBetween the virus–human componentsPut a physical barrier between HIV+ people and other people so virus cannot move from one body to another (containment)Example: knowledge of status & appropriate use of particular barrier method
Impact: variable/problematic (Shisana et al. 2014) [involves complex interdependencies]
Outlier – window periodWithin the virus component of the virus–human–environment heuristicNo intervention to dateExample: during the window period, the body does not recognise that the virus is in the body; so the virus is able to replicate exponentially (Abu-Raddad et al. 2013)
Impact: tackling the window period – which accounts for over 40% of new infections (Pettifor et al. 2011) could have a significant impact on the trajectory of the epidemic (Parkhurst & Whiteside 2010) [but it would involve managing complex interdependencies]

Source: authors’ contribution.

Source: authors’ contribution. Autopoietic interdependencies that defy easy explanation through traditional Newtonian science – especially when they intersect at multiple scales – are central to grappling with the unexpected outcomes of a particular series of complex events (Lorenz 1972; Walby 2007) (see Table 4, column 4). One of the more successful attempts at dealing with these complex relationships is the way in which periconception decision-making amongst serodiscordant, or discordant, couples is now managed in South Africa – although it is –as yet–an imperfect process (Barker, Barron, Bhardwaj & Pillay 2015; Matthews et al. 2013). However, from a complexity perspective, many of the ‘extraordinary changes in the AIDS landscape achievements’ (UNAIDS 2014b) can be attributed to the deliberate management of patterns that sustain phenomena that influence the trajectory of the epidemic.
Table 4.

Themes that were surfaced through the Archetype Extraction technique.

Surfaced themesManagement response typology (the Cynefin framework)
Community ‘assets’ObviousComplicatedComplexChaos
Some people adhering to medication  
Dedicated health care workers (including nurses and home-based carers)  
Dedicated/supportive community members  
Human rights activism   
Voluntarism   
Young women committed to education  
Dedicated drop-in-centre workers  
Community ‘challenges’ObviousComplicatedComplexChaos
Loss to follow-up/non-adherence  
Mental health challenges  
Sense of hopelessness amongst youth  
Alcohol abuse  
Stigma (including clinic staff members, community members and children)  
Conflict between traditional medication and traditional medication  
People supplying ‘fake medicine’ in the community   
Intergenerational sex (Ministers of Transport/Finance)   
Multiple partners   
Teenage pregnancy   
School drop-out due to pregnancy  
Violence within the community (including knives being brought into drop-in-centres by children)  
Conflict between traditional values and modern values   

Source: authors’ contribution.

Typically, a new intervention typology has the effect of replacing one set of patterns that enable the virus to replicate, with a new set of patterns that reduce the virus’ ability to flourish. In the early stages of the intervention, the new patterns demonstrate weak interconnections, but with time – through the process of autopoiesis – the relationships that hold successful interventions together develop into self-energising interdependencies. Autopoiesis is the process that strengthens novel connections as they mature into interdependent forms of emergence and is thus a critical mediator of intervention success or failure. Many interventions indirectly reinforce the process of autopoiesis by focusing on the visible, surface descriptors of change – such as health promotion campaigns, but, as far as we are aware, there is no evidence that any interventions deliberately attempt to identify weak signal indicating shifts in patterned interactions or interdependencies; nor are there management strategies within the HIV/AIDS landscape designed to respond to these changes. It is for this reason that we now turn to weak signal detection and the Cynefin framework (Snowden & Boone 2007).

Weak signal detection

Weak signal detection – first coined by Ansoff (1975) in ‘Managing Strategic Surprise by Response to Weak Signals’ – is an ongoing process of scanning an environment for clues that indicate that discrete changes in the environment are occurring. For futures scientists, detecting any evidence of novel emergence is described as a ‘weak signal’ – ‘(external or internal) events and developments that are still too incomplete to allow an accurate estimate of their impact and/or to determine a full adapted response [are detectable]’ (Ansoff 1975, cited in Sidhom & Lambert 2011:40). Weak signal detection is a method that illuminates – or surfaces – the development of new interconnections; existing interconnections or interdependencies and changes in the strengths, or influence, of the interconnections between and within the system – and is thus an opportunity to identify opportunities to influence the trajectory of the epidemic, albeit working at discrete scales. The reason for scanning the environment for these discrete changes is that these changes hold the potentials to develop into more significant phenomena as they intersect with a planned ambition. This intersection – if it co-evolves into a significant phenomenon – has the potential to either reinforce the planned vision, or to obstruct it. Futures scientists have been devising and documenting mechanisms to better understand and improve weak signal detection (Harris & Zeisler 2002; Kaivo-oja 2012; Sidhom & Lambert 2011) so that foresight can be developed and responded to, based on their understandings of the process of autopoiesis (Mendonça, Cardoso & Caraça 2012). The significance of detecting weak signals is that when working with complex adaptive systems it is possible at particular historical junctures to show – or at least identify clues – that a change process is beginning which may require a management response. Differentiating between the types of management response to weak signals is the next issue to be addressed.

Management responses to ‘weak signals’

In a seminal article called ‘A Leader's Framework for Decision Making', Snowden and Boone (2007) argue that many decisions can be improved by correctly identifying the context within which decisions are being made — called the Cynefin framework (Fig. 3). The framework is influenced by the work of Klein (2008:457), who described how people make decisions using the ‘recognition-primed decision (RPD) model [which] describes how people use their experience in the form of a repertoire of patterns’. Specifically, Klein suggests that when people want to make a decision and ‘can quickly match the [decision making] situation to the patterns they have learned’ they typically take this first option – rather than take stock of the situation and make a decision based on a more holistic scanning of the context within which the situation is embedded (Klein 2008:457).
Fig. 3

The Cynefin framework. Source: http://en.wikipedia.org/wiki/Cynefin.

The Cynefin framework. Source: http://en.wikipedia.org/wiki/Cynefin. Snowden and Boone's work provides a heuristic that decision-makers can apply to evaluate the contextual situation prior to making a decision – thus avoiding the ‘first pattern fit’ that could lead to an inappropriate decision. The heuristic is split into four quadrants which represent different decision-making contexts. The ‘obvious’ and ‘complicated’ quadrants represent the realm of ordered Newtonian science where decision-making is constrained by rationality because cause and effect is discernible. The ‘complex’ and ‘chaotic’ domains represent ‘unordered’ contexts where the constraints of rationality are lifted – by different degrees – because cause and effect is only discernible in retrospect, which means that ‘the agents and the system constrain one another, especially over time. This means that we cannot forecast or predict what will happen’ (Snowden & Boone 2007:70). In the ‘unordered’ contexts, it is ‘futile’ to look for solutions to problems based on the presumptions associated with the ‘ordered’ Newtonian legacy (Wilson & Holt 2001). There is a fifth domain situated in the middle of the Cynefin framework called ‘disorder', where no consensus as to the nature of the problem dominates. Each of the domains contains generic management responses that are appropriate to the different domains and can be applied to a generalised HIV/AIDS epidemic (Table 3).
Table 3.

The Cynefin framework and HIV/AIDS.

QuadrantKnowledge/decision-making domain → management responseExamples
Obvious problems (solutions are known) – such as following a protocol, may encompass some basic issues of technique and terminology, but once these are mastered, following the ‘recipe’ carries with it a very high assurance of successAnalytical/reductionist evidence-based action/s → Sense-categorise-respond (a known best practice)TasP; PMTCT; pre- and post-exposure prophylaxis; reduction of co-infections; correct and consistent condom use
Complicated problems (solutions are knowable) – contain subsets of simple problems but are not merely reducible to them. Their complicated nature is often related not only to the scale of a problem such as open heart surgery, but also to issues of coordination or specialised expertise. Complicated problems, although their solutions are generalisable, are not simply an assembly of simple componentsPotentially ascertainable by application of evidence-based methods → Sense-analyse-respond (good practices exist but they are not 100% fool-proof)Respond to drug resistance with an alternative medication and monitor for side-effects then adapt as necessary; management of the intersection of HIV with other chronic conditions; periconception decision-making for serodiscordant couples
Complex problems (solutions are understandable with time) – can encompass both complicated and simple subsidiary problems, but are not reducible to either, as they too have special requirements, including an understanding of unique local conditions. Historical adaptive, self-organisational social networks with observable patterns that are neither predictable nor generalisable, yet can open up numerous possibilitiesNon-predictable, but potentially understandable by pattern observation → Probe-sense-respond (pattern management/safe-fail experimentation)Carefully controlled interventions such as the microfinance initiative that amalgamated novel combinations to influence the structural drivers of HIV/AIDS (Pronyk et al. 2006)
Chaotic problems (solutions are not understandable until stabilised) – implies being out of control, with no discernible order. Yet chaos can break old restrictive connections and liberate space for a new order. Retrospective analysis of how chaos is managed and capitalised on is essential evidence for understanding systemsTrue chaos represents a major system failure and requires charisma or dictatorship to stabilise the situation → Act-sense-respond (crisis management)The emergency response to HIV/AIDS in the Philippines by Health Minister Flavier in the 1990s which ushered in the ‘abstain, be faithful, condomise’ campaign to raise awareness that unprotected sex was risky (Hardee et al. 2013)
Disordered problems – applies to situations where there is no consensus about the knowledge type that is the focus of the challengeIntuitive debate/argument. People tend to favour future actions based on their particular frameA national South African report recommending that ABC can ‘equip the population with basic knowledge about HIV prevention’ (Shisana et al. 2014:xl) compared with other suggestions that the global mind-set needs to shift towards managing the epidemic as a chronic disease (Dybul 2014; UNAIDS 2014a)

Source: adapted from Martin and Sturmberg (2005).

Source: adapted from Martin and Sturmberg (2005). Each decision is prompted by a signal. Some signals prompt clearly defined management responses because the solution is already known; other signal responses are more ‘complicated’ because the solution is available, but elusive; other signal responses are ‘complex’ because there is no known solution and some signal responses require crisis management because the situation is ‘chaotic’ and requires stabilisation prior to managing it. At first glance, applying this framework to the HIV/AIDS landscape suggests that many of the challenges associated with ‘ending AIDS’ are now realisable. However, in the naturalistic, ‘real-world’, contexts of interdependencies and interconnections that enable the virus to flourish – the situation points to ambiguity (see Table 2). The ambiguity contained within Table 2 points to the inherent complexity of managing a generalised epidemic and emphasises the importance of the fifth – disordered – domain of the Cynefin framework. ‘The way out of this realm is to break down the situation into constituent parts and assign each to one of the other four realms. Leaders can then make decisions and intervene in contextually appropriate ways’ (Snowden & Boone 2007:71).

Overview of the above

Influenced by future scientists’ interest in anticipatory awareness of what might occur in the future – and UNAIDS’ Vision 90:90:90 of what could occur by 2030 – we have introduced some concepts that include landscapes in transition and complexity theory, including emergence and autopoiesis. Emergence tells us something about what can happen when systems intersect – but not about the potential impact of that emergence. Autopoiesis is the glue that turns weak interconnections into patterned – long term – interdependencies that generate sustainable phenomena. We have thus argued that visible, surface descriptors associated with the HIV/AIDS landscape are sustained by less visible patterns of interactions and that some of these patterns are robust, ‘organised’ autopoietic patterns, after Weaver (1948), and other patterns are weaker – or ‘disorganised’ – but could coalesce into organised patterns as they intersect with the epidemiological landscape (Ansoff 1975). Managing these patterns could contribute to achieving Vision 90:90:90 and so we introduced two implementation frameworks – weak signal detection and the Cynefin framework. Weak signal detection, albeit in imperfect form, has been used to improve ‘decision-making’ using foresight in a many different contexts (Kaivo-oja 2012). The Cynefin framework is a decision-making heuristic that enables appropriate management responses to signals. Combining weak signal detection with the Cynefin framework represents an avenue for introducing these concepts into the management of complex, adaptive HIV/AIDS landscapes. From this theoretical position, we now turn to our own field experiences of identifying and responding to weak signals.

Case material

Two case studies are presented. The case studies were undertaken in the Limpopo Province of South Africa during 2011–2013. The work took place in a community of approximately 35,000 people called Ga-Dikgale in the Capricorn district. The case studies include techniques that are believed to offer opportunities to surface weak signals and the more discrete properties of the system of interest. The first approach that was piloted is called Archetype Extraction and the second involved the use of the SenseMaker® Collector™ tool (Raford 2012).

Ethics approval

All research ethics were observed in conducting the study. Prior to both rounds of data collection, permission for ethical clearance was obtained from the Turfloop Research and Ethics Committee, University of Limpopo. The participants were assured of their anonymity and confidentiality before both written and verbal consents were obtained from them to take part in the study.

Archetype extraction

Archetype extraction involves eliciting micro-narratives from a group of people about a specific theme and asking them to ‘make sense’ of the experience (James & Minnis 2004). Narrative investigations are considered to be a mechanism to surface ‘tacit knowledge’ – after Nonaka and Takeuchi (1995) –based on the assumption that narrative is the ‘bridge between tacit and explicit knowledge’ (Linde 2001:160). For the purposes of the pilots, the focus was on any tacit influence – rather than just knowledge – that shaped the feedback patterns within a particular system of interest. The methodology is based upon a two-step process. The first step is called the Discovery Phase, based on a group discussion called an Anecdote Circle Anecdote Circle and the second phase is the Sense-Making Phase. The Discovery Phase elicits the visible phenomena the participants associate with the theme under discussion, including characters, behaviours and places. The Sense-Making Phase is designed to surface the less-visible themes that the participants associate with the phenomena identified in the Discovery Phase, such as enabling or constraining values, assumptions and biases that are ‘tacitly’ associated with the visible phenomena, which become the basis of the archetypes. Once the archetypes have been constructed by the participants, they are named and an artist is then requested to sketch the archetype – as directed by the participants. All of the findings are coded throughout the process so that links between the archetype and the earlier phases can be identified during the analysis. For a detailed account of the process, see Maree, Roux and Marais (2006). It is claimed that from this technique ‘representations of culture’ – including the patterns that sustain a particular cultural form – are surfaced (Snowden 2002:4). Six pilots were undertaken over an 18-month period with participants comprising male and female groups between the ages of 18 and 24 that work in drop-in-centres. Each group was composed of no more than 25 people. The focus of each workshop was HIV/AIDS and the local community. The findings of the Archetype Extraction technique were then situated on the Cynefin framework by the research team so that a contextualised management response was prepared.

SenseMaker®

In this case study, an attempt was made to surface development-related issues from people in rural Limpopo using the SenseMaker® Collector™ tool – not just HIV/AIDS-related issues. SenseMaker® is capable of managing vast amounts of data which can be retrieved in real-time. In this instance, over 1000 respondents were asked to provide micro-narratives that were based on empirical experiences of their own – or one that they were aware of. Once the micro-narrative was provided, the respondents were asked to code their narrative against a set of pre-chosen signifiers. The data were subsequently loaded into the SenseMaker® Collector™ tool, which enables ‘qualitative input in the form of stories, anecdotes and narratives (which have the potential to convey rich social meaning and are easily recalled and communicated), with quantitative indices allowing for this data to be quickly coded, classified and analyzed’ (Raford 2012:118). It also provides a visual platform that ‘enable[s] users to view patterns and anomalies not otherwise visible through conventional methods for analysis of narrative information’ (Casella, Magara, Kumasi, Guijt & van Soest 2014:18). The SenseMaker® tool enables the immediate retrieval of the original narrative during the analysis process so that specific details can be analysed once the patterns are more thoroughly understood. For a detailed account of applying the SenseMaker® Collector™ tool, see Casella et al. (2014) and GlobalGiving (2014).

Results

Archetype Extraction

The Archetype Extraction process surfaced a diverse range of themes that the community members associated with HIV/AIDS in their area. It was possible to situate the themes on the Cynefin framework so that a management response could be identified. The themes included community ‘assets’ and ‘challenges’ that could be responded to. Table 4 provides an overview of the dominant recurring themes – or patterns – that emerged and a management response typology that is aligned to the Cynefin framework heuristic. Source: authors’ contribution. Table 4 provides an overview of the dominant recurring patterns that the Archetype Extraction technique elicited. It demonstrates that there are many ‘assets’ that can be built upon – or reinforced – and also many ‘challenges’. The management responses to the ‘assets’ are typically ordered responses which are responsive to good – or best – practices, so that the impact of the assets can be increased. The management responses to the ‘challenges’ are typically unordered – containing some ‘non-linear relationships’ between the component parts (Stirzaker et al. 2010) – and therefore, following Snowden and Boone (2007), require pattern management responses to destabilise or disrupt the discrete patterns that sustain the visible challenges identified by the participants because there is no good or best practice to hand.

Weak signal detection

From the perspective of the researchers, the prevalence of mental health challenges – often labelled as ‘hopelessness’ by the participants – was considered a weak signal because of the extent of reporting. Many of the images included graphic representations of people ‘hanging themselves up’ (committing suicide by hanging) and depressed young people. However, while the participants were extremely concerned by the recent emergence of mental health challenges, it was no longer a surprise to them. A second weak signal that emerged was called the ‘Vicious Tollgate’ (Fig. 4). This archetype represented the use of a recreational drug known as ‘Whoonga', which is believed to contain a cocktail of antiretroviral medication, rat poison and alcohol. Coding this archetype back to the Discovery Phase suggested that lazy community members, crooks and patients were associated with the archetype.
Fig. 4.

The Vicious Tollgate: surfacing Whoonga in 2011. Source: authors’ contribution.

The Vicious Tollgate: surfacing Whoonga in 2011. Source: authors’ contribution. The third ‘weak signal’ that emerged was an image of a government worker (Fig. 5). This archetype was considered to be a weak signal because it was the only representation that appeared to point directly at the role of government from all the workshops.
Fig. 5.

The ‘Opinionated Idiot’ archetype. Source: authors’ contribution.

The ‘Opinionated Idiot’ archetype. Source: authors’ contribution. However, when the associations were identified from the coding, it became evident that the participants were linking ‘opinionated idiots’ to the community. During a subsequent discussion with the participants, it became evident that these associations did reflect frustrations with government responsiveness, but also to the way in which the conflict between traditional values and the opportunities provided by biomedical opportunities was a challenge in the area (Fig. 6).
Fig. 6.

The Cycle of Treatment-Seeking Behaviour in Ga-Dikgale. Source: authors’ contribution.

The Cycle of Treatment-Seeking Behaviour in Ga-Dikgale. Source: authors’ contribution. Fig. 6 represents the reported reality of treatment-seeking against the way the participants believe – rationally – what ‘should’ happen amongst their community. When asked to rate the confidence in the different treatment options on a scale of one to five (with five being the most confidence), they rated hospital – or clinic-based sources with a five, prophets with a three and traditional healers with a one. After a circuitous journey, it became clearer that one of the major, emergent weak signals was the participants’ frustration of how their community was to negotiate the ‘traditional/modern’ value system in the sphere of health – and that this challenge referred to other chronic conditions, not just HIV/AIDS. The focus of the research that is reported on was ‘development in general’ – not HIV/AIDS, per se. SenseMaker® enables the data to be analysed in a number of different ways (Raford 2012). As was explained in the methodology, the micro-narratives that are collected are indexed by the storyteller against a set of pre-defined signifiers. The signifiers we report on are: development issues that the community ‘see regularly’; issues that they ‘see occasionally’ and issues that ‘have never seen before’. A total of just over 1300 micro-narratives were indexed against these signifiers (Fig. 7).
Fig. 7.

Development themes coded by ‘regularity’ (n = 1087 micro-narratives). Source: authors’ contribution.

Development themes coded by ‘regularity’ (n = 1087 micro-narratives). Source: authors’ contribution. Each of the dots in Fig. 7 represents a micro-narrative, and SenseMaker® enables the end-user to manipulate the data in many ways. Fig. 8 shows the same data, filtered by ‘things the community will never accept’ coupled with ‘experiences people have never seen before’.
Fig. 8.

The same data filtered by ‘something the community will never accept. Source: authors’ contribution.

The same data filtered by ‘something the community will never accept. Source: authors’ contribution. The small cluster in the bottom right-hand corner of the triangle may represent the development of a weak signal within the data set (Casella et al. 2014). By selecting the stories highlighted in the circle provides the user with immediate access to the micro-narratives for deeper analysis about what the weal signal represents. The same data can also be represented using another application of SenseMaker® called ‘Landscape’ (Fig. 9).
Fig. 9.

The same data when viewed through ‘Landscape’. Source: authors’ contribution.

The same data when viewed through ‘Landscape’. Source: authors’ contribution. The axes in Fig. 9 are the same as the signifiers shown in Fig. 8. The possible weak signals are highlighted in the white circles. Analysis of the content of the micro-narratives surfaces the more detailed patterns and included: corruption, jealousies, disillusionment with volunteerism and irritation with the poor infrastructure within the community (water, electricity and roads). There is no doubt that applying SenseMaker® in this way provided an extremely creative method for surfacing a massive amount of data in very manageable ways that combines both quantitative and qualitative data. However, it is uncertain to the authors as to whether this application of SenseMaker® surfaced any definitive weak signals.

Discussion

The Archetype Extraction technique did elicit a useful environmental scan that provided pre-hypothesis insights from the perspective of the community. Granted, the workshops were framed within a health theme in a top-down manner, but the rest of the workshop content was driven by empirical realities and the values of the participants. The process enabled the researchers to conduct a scan of the health-related landscape in the area and captured many complexities that local people associated with that particular landscape. The technique also surfaced some weak signals within that community, which included mental health issues, Whoonga and the challenge of negotiating ‘tradition and modernity’ in the context of managing a chronic disease. The Whoonga weak signal is the most striking example of the value that this technique can surface. A Google Scholar search in 2011 –when the data was collected –for ‘Whoonga’ and ‘South Africa’ revealed 8 ‘hits’ and the same search in 2014 revealed 49 hits – for example, see Grelotti et al. (2014). We suggest that this demonstrates that the weak signal focus is relevant when working with ‘long wave events’ (Fourie & Follér 2012) – such as the HIV/AIDS epidemic – because when novel forms of emergence begin to develop, communities are probably the first group of people to notice some of the weak signals, as is reported above. The Archetype Extraction technique emphasised – with the benefit of retrospect – that it was possible to surface weak signals, as well as providing insights into other issues that were considered relevant to the localised HIV/AIDS landscape from the perspective of the participants. Analysis of the findings using secondary literature and on-going community discussions enabled a slightly more nuanced analysis that suggests that of the three weak signals detected, two exhibit strong patterned interdependencies – mental health and the treatment-seeking cycle challenge – and Whoonga exhibits weaker interconnections. Combining the Archetype Extraction technique with the Cynefin framework enabled a management response to be articulated. However, the technique comes with caveats: The workshops are a cognitive overload for those involved and this makes the process very demanding on participants; Working with an artist necessarily involves the possibility that his, or her, bias can influence the representations of the archetypes; The images – which some have claimed can be used in the future to prompt debate (Snowden 2002) – were subsequently of little research value in our context. Attempts were made to prompt further community discussions using the images but all of these efforts produced minimal returns. In retrospect, the sketches (see Fig. 4) were justifiable, but the resources required to develop the sketches into quality graphics (see Fig. 5) are unjustifiable; Scale. While Archetype Extraction was manageable at the localised scale of one community – it is difficult to imagine how this technique can contribute to Vision 90:90:90, if applied as a standalone technique. The final caveat is the potential of the research team to respond to the findings. We were able to respond to the mental health challenge by initiating one MDev thesis (Aphane 2015). However, in the eyes of the community, this is not a timely response, nor the one they were hoping for. The issue of Whoonga appears to have been short lived because it is no longer considered relevant by the community and the challenge of negotiating ‘tradition and modernity’ remains an on-going challenge. In reality, an impact-oriented Community Engagement unit – such as the one that drove the pilots – is not well placed to respond with either the speed or resources to deliver a ‘real-time’ response that can have immediate impact in such instances. Our experiences with SenseMaker® did elicit some phenomena that could be described as weak signals – such as people becoming disillusioned with ‘volunteerism’. However, our experience was a single application and not a historical application of it. For this reason, we briefly describe a much larger application in East Africa – for more details, see GlobalGiving (2014). GlobalGiving collected approximately 30,000 micro-narratives from 2010 to 2013. By cross referencing their data with other software, they were able to generate maps that showed the characteristics of a massive area by themes that were relevant to the communities they were involved with (Fig. 10) and also to generate visual representations of the weight that community respondents attributed to different development challenges (Fig. 11).
Fig. 10.

Themes from Uganda and Kenya and the number of beds per clinic represented by the size of the circle. Source: Maxmeister (2014).

Fig. 11.

The number of times different themes were mentioned in micro-narratives in the GlobalGiving project. Source: Maxmeister (2014).

Themes from Uganda and Kenya and the number of beds per clinic represented by the size of the circle. Source: Maxmeister (2014). The number of times different themes were mentioned in micro-narratives in the GlobalGiving project. Source: Maxmeister (2014). The GlobalGiving data demonstrate how SenseMaker® enables data analysis at multiple scales. This is particularly relevant to one of UNAIDS action points that they believe to be an essential component of ‘ending AIDS’. Specifically, they argue that in Action Point # 4 that it is necessary to ‘Focus on local epidemics and populations’ and then recommend It is important to continue to collect and analyse data at the subnational level, district by district, and in cities to identify areas of high incidence of HIV infection and the socio-behavioural reasons that contribute to people becoming newly infected with HIV. With local information, HIV services can be scaled up and saturated to meet community needs. (UNAIDS 2014b:301) Our experience with SenseMaker® suggests the software, if appropriately applied, has the capacity to contribute to UNAIDS’ call for complementary analyses of the epidemic at multiple scales. Other experiences, such as the GlobalGiving experience (Whittle 2010), demonstrates that it is possible to elicit and analyse thousands of community ‘voices’ and perspectives – emphasising that the SenseMaker® Collector™ tool has extraordinary potential. However, we still emphasise that a historical – or longitudinal – application of SenseMaker® can add more value (Fig. 12).
Fig. 12.

Historical data using Landscape. Source: Cognitive Edge training materials, available at http://cognitive-edge.com/uploads/presentations/CE%20Accreditation%20SENSEMAKER%20feb%2008.pdf. Reproduced with permission.

Historical data using Landscape. Source: Cognitive Edge training materials, available at http://cognitive-edge.com/uploads/presentations/CE%20Accreditation%20SENSEMAKER%20feb%2008.pdf. Reproduced with permission. Fig. 12 is reproduced from training materials and the axes labels are unknown. The purpose of the representation is to demonstrate a longitudinal application of SenseMaker®. The circle in the bottom left-hand corner of the final image represents a new cluster of voices emerging. These could represent weak signals that would require management attention if SenseMaker® was being used to contribute to Vision 90:90:90. As with the Archetype Extraction technique, our application of SenseMaker® came with caveats: As has been noted above, our application included only one round of data collection and our intuition informs us that the value-add of SenseMaker® lies as in a longer term commitment so that historical data can be captured and applied; The application of SenseMaker® implicitly requires stepping outside of the Gaussian box and an understanding of Power Laws, thus the ability to move towards embracing abductive thinking, as much as more traditional forms of inductive or deductive thinking – see Snowden (2011) and Andriani and McKelvey (2007) for more details of the relevance of Power Laws to developing strategic foresight. A more thorough understanding of this would have added value to the preparation phases of this project.

Could the application of SenseMaker® – or similar software – become a realistic proposition?

SenseMaker® has now been used in multiple fields including: scenario planning in the United Arab Emirates (UAE) (Raford 2012); water and sanitation in Ghana (Casella et al. 2014) and gender by an international development agency (DFID 2014). Our experience of SenseMaker® was laborious because the micro-narratives were collected using voice recorders and then transcribed and loaded into SenseMaker®. By far the most efficient way of doing this is to do it directly online. With the exponential growth in connectivity and ‘smart’ technologies, it is now possible to imagine mass data collection in South Africa. For example, thousands of students across the country are involved with community outreach or engagement activities – all of whom have access to the internet. Likewise, community healthcare workers are becoming increasingly connected. If the SenseMaker® Collector™ tool were used to host diaries from all of these people working within communities, then the data that would emerge would be sizeable and the flexibility of SenseMaker® would enable real-time analyses at multiple scales across the country. Given the wealth of global lessons learnt about the application of this tool, it is now possible to imagine applying it to South Africa's eHealth strategy in a pilot format as a mechanism for contributing to Vision 90:90:90.

The complexity of achieving Vision 90:90:90 in a five-year time-frame

It is argued that achieving Vision 90:90:90 is now plausible because of the unprecedented biomedical opportunities to ‘end AIDS’ (UNAIDS 2014b). However, recent evidence shows that there is a significant gap between prevention efforts and the opportunities that the biomedical gains provide (Michielsen, Chersich, Luchters, De Koker, Van Rossem & Temmerman 2010), with the ‘number of newly infected people each year continu[ing] to outnumber those who gain access to treatment’ (Pandor 2014). This is just one of many existing challenges that will intersect with achieving Vision 90:90:90. Not only are there existing challenges to achieving Vision 90:90:90; new challenges are likely to emerge in unpredictable ways. This makes the ‘five-year’ journey a complex journey.

Negotiating a complex journey

We have demonstrated that it is possible to move beyond an exclusive focus on visible descriptors of phenomena by surfacing the discrete patterns that influence the descriptor – also known as ‘first’ and ‘second-order’ change (Bishop, Dzidic, Breen & Bishop 2013). This is especially relevant in complex scenarios because in this context ‘second’-order change represents an autopoietic driver of social practices (Auerbach, Parkhurst & Caceres 2011; Burman, Moerschell, et al. 2015). UNAIDS informs us that ‘[i]ncreasingly we are seeing multiple epidemics in countries. Never has it been more important to focus on location and population – to be at the right place for the right people’ (UNAIDS 2014b:5). These locations and populations often produce contexts that are characterised by – and emphasise –the ‘extreme complexity of health and disease’ (Peter Piot in UNAIDS 2015:58). Negotiating multiple, complex journeys requires an epistemological shift from the over-reliance on Newtonian ‘good’ or ‘best’ practices that are effective for constrained, ‘ordered’ challenges to management responses that can also embrace ‘organised’ and ‘disorganised’ forms of unconstrained, complexity – characterised by non-linearity, emergence and unpredictability. Snowden and Boone (2007) argue that this type of challenge is best approached through participatory management of the emergent, discrete patterns, regardless of whether the patterns are the result of disorganised interconnections or organised interdependencies. The purpose of managing these patterns is to either reduce or increase autopoietic tendencies, or to reinforce, or destabilise, existing autopoietic interdependencies so that the direction of change can be influenced (Becker 2011). This is reinforced by Coleman, Vallacher, Nowak and Bui-Wrzosinska (2007:1459), who argue that ignoring the second-order ‘mechanisms that continually reinstate the [original condition] are likely to be futile, resulting only in short-term changes’. With time and experience, the unordered, complex challenges may shift and become more ordered – with an associated ameliorative ‘good’ or ‘best’ practice. Until that time, it is necessary to expect that ‘pattern management’ should dominate the responses to the complexities situated within the diverse epidemiological landscapes. Evidence of what this approach might look like are few and far between (Dickens 2012) – but working with communities who ‘know’ their HIV/AIDS landscape (Wilson & Halperin 2008) seems key (Chu & Selwyn 2011; Dybul 2014) – ‘because prevention efforts are shaped by the specificities of what they [communities] value’ (Kippax, Stephenson, Parker & Aggleton 2013:1368).

Key policy recommendations

Given that the epidemic is now considered to be at a tipping point moment that could culminate in ending AIDS and that achieving this means that ‘a business-as-usual approach or simply sustaining the AIDS response at its current pace cannot end the epidemic’ (UNAIDS 2014b:296), we have two recommendations. The first suggestion is that it is now necessary to critically examine the logic of only focusing on the visible descriptors of high risk groups – as most policy documents suggest – if Vision 90:90:90 is to be achieved. We recommend that when there are clear-cut, effective responses to ordered challenges associated with high risk contexts – then a focus on the visible descriptors is an appropriate management focus. However, when challenges are unordered, it is more of an appropriate management response to focus on the underlying patterns – simultaneously remaining mindful of the visible descriptors. This requires that the ‘development of innovative new approaches for HIV prevention’ (SANAC 2012:70) includes transdisciplinary migrations into relatively uncharted epistemological waters, such as complexity and futures science, so that patterned dynamics can be captured – and worked with – to contribute to Vision 90:90:90. This could be achieved by incorporating software such as SenseMaker® into national surveys – such as the four-year South African National HIV Prevalence, Incidence and Behaviour Survey – so that real-time ‘patterned’ data, representing multiple scales of intersecting data reflecting the different components of the national epidemic is generated and exploited to achieve Vision 90:90:90. The second recommendation focuses on UNAIDS' call for a qualitatively unique shift from a ‘response mode’ to a ‘mission mode' (UNAIDS 2014b:299). The eight action points are all recommendations that focus on the visible, first-order, surface descriptors of actions. We have argued that beneath the surface descriptors there are discrete, second-order, forces that will influence the descriptor. One relevant, discrete mediator of Vision 90:90:90 is – almost certainly – the absence of any evidence that demonstrates that, within the analytical HIV/AIDS landscape, people are considering the possibility that Power Laws are better positioned to explain some of the visible characteristics of the epidemic than traditional Gaussian assumptions. If ‘the “Achilles heel:” of the bell curve is the word independent’ – Buchanan in Ramalingham (2013:217) – and, as we have seen, so much of the landscape is intimately connected through feedback and relationships, the time is ripe to consider a think tank scenario to fill this anomaly.

Conclusion

We have provided a transdisciplinary journey that includes a complexity and futures orientation that could contribute to achieving Vision 90:90:90. This transdisciplinary migration has included a theoretical foundation and some empirical findings to support the case. We have argued that when managing a complex, adaptive landscape, the development of an anticipatory surveillance system that is capable of identifying weak signals has been shown to add value in other contexts. We suggest that real-time, adaptive response capacity is required to act on the weak signals that emerge – or already exist – within the HIV/AIDS landscapes can add value to Vision 90:90:90. We have also suggested that software – such as SenseMaker® – can be used to develop real-time data that can dovetail with the South African eHealth strategy and that a real-time response is critical because of the five-year time-frame. The rationale for this is implicitly embodied within the claim by UNAIDS that the next five years are critical to achieving the end of AIDS and we suggest that the compressed journey will necessarily entail radical forms of change. Many of the changes that will be encountered are distinctly complex and therefore require both transdisciplinary and epistemological migrations, underwritten by the ontological dexterity to embrace both the ordered and unordered ‘faces’ of the epidemic. By combining weak signal detection techniques with the Cynefin framework could provision decision-makers with a national management tool for developing anticipatory resilience to changes that might occur amongst the patterns below the surface of the HIV/AIDS landscape – thus contributing to achieving Vision 90:90:90. Without such innovative migrations and implementation strategies, we suggest that achieving Vision 90:90:90 will be similar to the history of the epidemic: a turbulent and difficult landscape to negotiate.
  42 in total

1.  Continued high risk sexual behavior following diagnosis with acute HIV infection in South Africa and Malawi: implications for prevention.

Authors:  Audrey Pettifor; Catherine MacPhail; Amy Corneli; Jabu Sibeko; Gift Kamanga; Nora Rosenberg; William C Miller; Irving Hoffman; Helen Rees; Myron S Cohen
Journal:  AIDS Behav       Date:  2011-08

2.  Requisite simplicities to help negotiate complex problems.

Authors:  Richard Stirzaker; Harry Biggs; Dirk Roux; Paul Cilliers
Journal:  Ambio       Date:  2010-12       Impact factor: 5.129

3.  Complex adaptive chronic care - typologies of patient journey: a case study.

Authors:  Carmel M Martin; Deirdre Grady; Susan Deaconking; Catherine McMahon; Atieh Zarabzadeh; Brendan O'Shea
Journal:  J Eval Clin Pract       Date:  2011-04-17       Impact factor: 2.431

4.  Embracing the complexity of HIV immunology.

Authors:  Guido Silvestri
Journal:  Immunol Rev       Date:  2013-07       Impact factor: 12.988

5.  Considering the complexity in HIV/AIDS and the environment.

Authors:  Kathryn J Fiorella
Journal:  Am J Public Health       Date:  2013-07-18       Impact factor: 9.308

Review 6.  Addressing social drivers of HIV/AIDS for the long-term response: conceptual and methodological considerations.

Authors:  Judith D Auerbach; Justin O Parkhurst; Carlos F Cáceres
Journal:  Glob Public Health       Date:  2011-07-11

Review 7.  Global epidemiology of HIV among female sex workers: influence of structural determinants.

Authors:  Kate Shannon; Steffanie A Strathdee; Shira M Goldenberg; Putu Duff; Peninah Mwangi; Maia Rusakova; Sushena Reza-Paul; Joseph Lau; Kathleen Deering; Michael R Pickles; Marie-Claude Boily
Journal:  Lancet       Date:  2014-07-22       Impact factor: 79.321

8.  The neglected triple disease burden and interaction of helminths, HIV and tuberculosis: an opportunity for integrated action in South Africa.

Authors:  Z L Mkhize-Kwitshana; M L H Mabaso
Journal:  S Afr Med J       Date:  2014-04

Review 9.  The end of AIDS: HIV infection as a chronic disease.

Authors:  Steven G Deeks; Sharon R Lewin; Diane V Havlir
Journal:  Lancet       Date:  2013-10-23       Impact factor: 79.321

10.  Systems change for the social determinants of health.

Authors:  Gemma Carey; Brad Crammond
Journal:  BMC Public Health       Date:  2015-07-14       Impact factor: 3.295

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  1 in total

Review 1.  Contemporary HIV/AIDS research: Insights from knowledge management theory.

Authors:  Chris William Callaghan
Journal:  SAHARA J       Date:  2017-12
  1 in total

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