| Literature DB >> 26820699 |
Keith Ahamad1,2,3, P Todd Korthuis4,5, Paula J Lum6, Cheyenne Johnson1, Evan Wood1,7.
Abstract
BACKGROUND: Pharmacotherapy, such as oral naltrexone, has proven effective in treating alcohol use disorder, although medication adherence has presented challenges. Although a formulation of extended-release naltrexone for intramuscular injection has been developed to counter daily adherence issues, injection-site reactions can occur within days of depot injection. CASE: The authors report a case of an individual with alcohol use disorder who had a previously undescribed delayed injection-site reaction that occurred 11 days after injection. Subsequent challenge with the medication resulted in recurrence of the reaction. DISCUSSION: Although extended-release naltrexone is generally well tolerated, injection-site reactions can complicate treatment and can appear more than 10 days after medication administration.Entities:
Keywords: Alcohol use disorder; extended-release naltrexone; injection-site reaction
Mesh：
Substances：
Year: 2016 PMID： 26820699 PMCID： PMC5266530 DOI： 10.1080/08897077.2016.1138919
Source DB: PubMed Journal: Subst Abus ISSN： 0889-7077 Impact factor: 3.716