Dan Wang1, Li Zhu1, Shulian Zhang1, Xueqin Wu2, Xiaoli Wang3, Qin Lv4, Dongmei Gan4, Ling Liu5, Wen Li6, Qin Zhou7, Jiarong Lu8, Haiying He9, Jimei Wang10, Hua Xin11, Zhankui Li12, Chao Chen1. 1. a Department of Neonatology , Children's Hospital of Fudan University , Shanghai , P.R. China . 2. b Zhejiang Jiaxing the First Hospital , Jiaxing , P.R. China . 3. c Shanghai Jiading Maternal and Child Care Hospital , Shanghai , P.R. China . 4. d Ningbo Women and Children's Hospital , Ningbo , P.R. China . 5. e Guizhou Maternal and Child Care Hospital , Guizhou , P.R. China . 6. f Qilu Hospital of Shangdong University , Shangdong , P.R. China . 7. g Jiangsu Wuxi Maternal and Child Health Care Hospital , Wuxi , P.R. China . 8. h Xinjiang Yili Maternal and Child Care Hospital , Yili , P.R. China . 9. i The Third Hospital of Baotou Steel Group , Baotou , P.R. China . 10. j Obstetrics and Gynecology Hospital of Fudan University , Shanghai , P.R. China . 11. k Xinjiang Boertala Hospital , Boertala , P.R. China , and. 12. l Shanxi Maternal and Child Care Hospital , Shanxi , P.R. China.
Abstract
OBJECTIVE: We examined the predictive macrosomia birthweight thresholds for adverse maternal and neonatal outcomes. STUDY DESIGN: This was a multicenter, retrospective cohort study conducted in China. We selected 178 709 singletons weighing ≥2500 g with gestational age 37-44 weeks. We categorized macrosomia with two gradations (4000-4499 g and ≥4500 g) and compared them with a normosomic reference group of infants with birthweight 2500-3999 g. RESULTS: The risks of obstetric and neonatal complications increased when infants had a birthweight of ≥4000 g. The rates of infant mortality, Apgar score ≤3 at 5 min, respiratory and neurological disorders rose significantly among neonates weighing ≥4500 g. CONCLUSION: A definition of macrosomia as birthweight ≥4000 g could be beneficial as an indicator of obstetric and newborn complications, and birthweight ≥4500 g might be predictive of severe infant morbidity and mortality risk.
OBJECTIVE: We examined the predictive macrosomia birthweight thresholds for adverse maternal and neonatal outcomes. STUDY DESIGN: This was a multicenter, retrospective cohort study conducted in China. We selected 178 709 singletons weighing ≥2500 g with gestational age 37-44 weeks. We categorized macrosomia with two gradations (4000-4499 g and ≥4500 g) and compared them with a normosomic reference group of infants with birthweight 2500-3999 g. RESULTS: The risks of obstetric and neonatal complications increased when infants had a birthweight of ≥4000 g. The rates of infant mortality, Apgar score ≤3 at 5 min, respiratory and neurological disorders rose significantly among neonates weighing ≥4500 g. CONCLUSION: A definition of macrosomia as birthweight ≥4000 g could be beneficial as an indicator of obstetric and newborn complications, and birthweight ≥4500 g might be predictive of severe infant morbidity and mortality risk.
Authors: Man Zhang; Marufu Martin Gazimbi; Zhong Chen; Bin Zhang; Yanru Chen; Yizhen Yu; Jie Tang Journal: BMJ Open Date: 2020-01-02 Impact factor: 2.692