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Literature DB >> 26820436

A twist in zygotic reprogramming.

Abstract

The first hours of mammalian embryogenesis are devoted to extensive epigenetic reprogramming. One hallmark is active demethylation of the paternal genome by Tet (ten-eleven translocation) enzymes. However, the process is now shown to be Tet-independent at first, with Tet enzymes only counteracting hitherto underappreciated de novo DNA methylation activity in later zygotic stages.

Entities: Chemical Species

Mesh：

Substances：
5-Methylcytosine
Cytosine

Year: 2016 PMID： 26820436 DOI： 10.1038/ncb3304

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

17 in total

1. Dynamic reprogramming of DNA methylation in the early mouse embryo.

Authors: Fátima Santos; Brian Hendrich; Wolf Reik; Wendy Dean
Journal: Dev Biol Date: 2002-01-01 Impact factor: 3.582

2. Dynamic link of DNA demethylation, DNA strand breaks and repair in mouse zygotes.

Authors: Mark Wossidlo; Julia Arand; Vittorio Sebastiano; Konstantin Lepikhov; Michele Boiani; Richard Reinhardt; Hans Schöler; Jörn Walter
Journal: EMBO J Date: 2010-05-04 Impact factor: 11.598

3. Active demethylation of the paternal genome in the mouse zygote.

Authors: J Oswald; S Engemann; N Lane; W Mayer; A Olek; R Fundele; W Dean; W Reik; J Walter
Journal: Curr Biol Date: 2000-04-20 Impact factor: 10.834

4. PGC7/Stella protects against DNA demethylation in early embryogenesis.

Authors: Toshinobu Nakamura; Yoshikazu Arai; Hiroki Umehara; Masaaki Masuhara; Tohru Kimura; Hisaaki Taniguchi; Toshihiro Sekimoto; Masahito Ikawa; Yoshihiro Yoneda; Masaru Okabe; Satoshi Tanaka; Kunio Shiota; Toru Nakano
Journal: Nat Cell Biol Date: 2006-12-03 Impact factor: 28.824

5. 5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming.

Authors: Mark Wossidlo; Toshinobu Nakamura; Konstantin Lepikhov; C Joana Marques; Valeri Zakhartchenko; Michele Boiani; Julia Arand; Toru Nakano; Wolf Reik; Jörn Walter
Journal: Nat Commun Date: 2011 Impact factor: 14.919

6. Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine.

Authors: Khursheed Iqbal; Seung-Gi Jin; Gerd P Pfeifer; Piroska E Szabó
Journal: Proc Natl Acad Sci U S A Date: 2011-02-14 Impact factor: 11.205

7. The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes.

Authors: Tian-Peng Gu; Fan Guo; Hui Yang; Hai-Ping Wu; Gui-Fang Xu; Wei Liu; Zhi-Guo Xie; Linyu Shi; Xinyi He; Seung-gi Jin; Khursheed Iqbal; Yujiang Geno Shi; Zixin Deng; Piroska E Szabó; Gerd P Pfeifer; Jinsong Li; Guo-Liang Xu
Journal: Nature Date: 2011-09-04 Impact factor: 49.962

8. Hypomethylation of paternal DNA in the late mouse zygote is not essential for development.

Authors: Zbigniew Polanski; Nami Motosugi; Chizuko Tsurumi; Takashi Hiiragi; Steffen Hoffmann
Journal: Int J Dev Biol Date: 2008 Impact factor: 2.203

9. De novo DNA methylation drives 5hmC accumulation in mouse zygotes.

Authors: Buhe Nashun; Kenjiro Shirane; Shoma Nakagawa; Rachel Amouroux; Peter Ws Hill; Zelpha D'Souza; Manabu Nakayama; Masashi Matsuda; Aleksandra Turp; Elodie Ndjetehe; Vesela Encheva; Nobuaki R Kudo; Haruhiko Koseki; Hiroyuki Sasaki; Petra Hajkova
Journal: Nat Cell Biol Date: 2016-01-11 Impact factor: 28.824