| Literature DB >> 26819827 |
Taeseok Daniel Yang1, Wonshik Choi1, Tai Hyun Yoon1, Kyoung Jin Lee1, Jae-Seung Lee2, Jang Ho Joo2, Min-Goo Lee3, Hong Soon Yim3, Kyung Min Choi3, Byoungjae Kim3, Jung Joo Lee4, Heejin Kim4, Doh Young Lee5, Kwang-Yoon Jung5, Seung-Kuk Baek5.
Abstract
Photothermal treatment methods have been widely studied for their target specificity and potential for supplementing the limitations of conventional surgical treatments. In this study, we conducted in vivo photothermal treatments using macrophages containing nanoshells as live vectors. We injected macrophages at the peritumoral sites and observed that they had penetrated into the tumor approximately 48 hours after injection. Afterwards, we irradiated with a near-infrared laser for 2 minutes at 1 W/cm(2), causing cancer cell death. Our study identified the optimal conditions of the photothermal treatment and confirmed the feasibility of its use in in vivo treatments.Entities:
Keywords: (170.0170) Medical optics and biotechnology; (170.5180) Photodynamic therapy; (350.5340) Photothermal effects
Year: 2015 PMID： 26819827 PMCID： PMC4722902 DOI： 10.1364/BOE.7.000185
Source DB: PubMed Journal: Biomed Opt Express ISSN： 2156-7085 Impact factor: 3.732