Literature DB >> 26819818

ATR-FTIR and Raman spectroscopic investigation of the electroporation-mediated transdermal delivery of a nanocarrier system containing an antitumour drug.

Boglárka Balázs1, Péter Sipos2, Corina Danciu3, Stefana Avram4, Codruta Soica5, Cristina Dehelean6, Gábor Varju7, Gábor Erős8, Mária Budai-Szűcs2, Szilvia Berkó2, Erzsébet Csányi2.   

Abstract

The aim of the present work was the optimization of the transdermal delivery of a lyotropic liquid crystal genistein-based formulation (LLC-GEN). LLC was chosen as medium in view of the poor solubility of GEN in water. Membrane diffusion and penetration studies were carried out with a Franz diffusion cell, through a synthetic membrane in vitro, a chick chorioallantoic membrane ex ovo, and ex vivo excised human epidermis. Thereafter, LLC-GEN was combined with electroporation (EP) to enhance the transdermal drug delivery. The synergistic effect of EP was verified by in vivo ATR-FTIR and ex vivo Raman spectroscopy on hairless mouse skin.

Entities:  

Keywords:  (120.7280) Vibration analysis; (170.3880) Medical and biological imaging; (170.5660) Raman spectroscopy; (300.6300) Spectroscopy, Fourier transforms; (300.6340) Spectroscopy, infrared; (300.6540) Spectroscopy, ultraviolet

Year:  2015        PMID： 26819818      PMCID： PMC4722911          DOI： 10.1364/BOE.7.000067

Source DB:  PubMed          Journal:  Biomed Opt Express        ISSN： 2156-7085            Impact factor:   3.732


  22 in total

1.  Transdermal delivery of macromolecules using skin electroporation.

Authors:  C Lombry; N Dujardin; V Préat
Journal:  Pharm Res       Date:  2000-01       Impact factor: 4.200

2.  Structure and drug release of lamellar liquid crystals containing glycerol.

Authors:  M Makai; E Csányi; Zs Németh; J Pálinkás; I Eros
Journal:  Int J Pharm       Date:  2003-04-30       Impact factor: 5.875

Review 3.  Skin electroporation for transdermal and topical delivery.

Authors:  Anne-Rose Denet; Rita Vanbever; Véronique Préat
Journal:  Adv Drug Deliv Rev       Date:  2004-03-27       Impact factor: 15.470

4.  Lyotropic liquid crystalline phases formed from glycerate surfactants as sustained release drug delivery systems.

Authors:  Ben J Boyd; Darryl V Whittaker; Shui-Mei Khoo; Greg Davey
Journal:  Int J Pharm       Date:  2006-01-04       Impact factor: 5.875

5.  Infrared and Raman imaging spectroscopy of ex vivo skin.

Authors:  Carol R Flach; David J Moore
Journal:  Int J Cosmet Sci       Date:  2012-11-29       Impact factor: 2.970

6.  In-vitro human skin penetration of the fragrance material geranyl nitrile.

Authors:  K R Brain; D M Green; J Lalko; A M Api
Journal:  Toxicol In Vitro       Date:  2006-09-05       Impact factor: 3.500

7.  Localization and interaction of genistein with model membranes formed with dipalmitoylphosphatidylcholine (DPPC).

Authors:  Bozena Pawlikowska-Pawlega; Lucjan E Misiak; Barbara Zarzyka; Roman Paduch; Antoni Gawron; Wiesław I Gruszecki
Journal:  Biochim Biophys Acta       Date:  2012-07

Review 8.  The chick embryo and its chorioallantoic membrane (CAM) for the in vivo evaluation of drug delivery systems.

Authors:  Angelica Vargas; Magali Zeisser-Labouèbe; Norbert Lange; Robert Gurny; Florence Delie
Journal:  Adv Drug Deliv Rev       Date:  2007-08-16       Impact factor: 15.470

9.  Delivery of ethinylestradiol from film forming polymeric solutions across human epidermis in vitro and in vivo in pigs.

Authors:  Ines Zurdo Schroeder; Patrick Franke; Ulrich F Schaefer; Claus-Michael Lehr
Journal:  J Control Release       Date:  2006-12-22       Impact factor: 9.776

10.  The Effect of Electroporation of a Lyotroic Liquid Crystal Genistein-Based Formulation in the Recovery of Murine Melanoma Lesions.

Authors:  Corina Danciu; Szilvia Berkó; Gábor Varju; Boglárka Balázs; Lajos Kemény; István Balázs Németh; Andreea Cioca; Alexandra Petruș; Cristina Dehelean; Citu Ioan Cosmin; Elena Amaricai; Claudia Crina Toma
Journal:  Int J Mol Sci       Date:  2015-07-08       Impact factor: 5.923
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  6 in total

1.  Full depth measurement of tenofovir transport in rectal mucosa using confocal Raman spectroscopy and optical coherence tomography.

Authors:  Aubrey L Presnell; Oranat Chuchuen; Morgan G Simons; Jason R Maher; David F Katz
Journal:  Drug Deliv Transl Res       Date:  2018-06       Impact factor: 4.617

2.  Quantitative two-photon microscopy imaging analysis of human skin to evaluate enhanced transdermal delivery by hybrid-type multi-lamellar nanostructure.

Authors:  Jinhyo Ahn; Kyeong Hu Kim; Kibaek Choe; Joo Hyuck Lim; Seung Ki Lee; Yeon Sook Kim; Pilhan Kim
Journal:  Biomed Opt Express       Date:  2018-07-31       Impact factor: 3.732

Review 3.  Imaging and quantifying drug delivery in skin - Part 2: Fluorescence andvibrational spectroscopic imaging methods.

Authors:  Ana-Maria Pena; Xueqin Chen; Isaac J Pence; Thomas Bornschlögl; Sinyoung Jeong; Sébastien Grégoire; Gustavo S Luengo; Philippe Hallegot; Peyman Obeidy; Amin Feizpour; Kin F Chan; Conor L Evans
Journal:  Adv Drug Deliv Rev       Date:  2020-03-23       Impact factor: 15.470

4.  Fabrication of a Ti porous microneedle array by metal injection molding for transdermal drug delivery.

Authors:  Jiyu Li; Bin Liu; Yingying Zhou; Zhipeng Chen; Lelun Jiang; Wei Yuan; Liang Liang
Journal:  PLoS One       Date:  2017-02-10       Impact factor: 3.240

5.  Controlled release of optimized electroporation enhances the transdermal efficiency of sinomenine hydrochloride for treating arthritis in vitro and in clinic.

Authors:  Shun Feng; Lijun Zhu; Zhisheng Huang; Haojia Wang; Hong Li; Hua Zhou; Linlin Lu; Ying Wang; Zhongqiu Liu; Liang Liu
Journal:  Drug Des Devel Ther       Date:  2017-06-15       Impact factor: 4.162

6.  Botanical Therapeutics: Phytochemical Screening and Biological Assessment of Chamomile, Parsley and Celery Extracts against A375 Human Melanoma and Dendritic Cells.

Authors:  Corina Danciu; Istvan Zupko; Andrea Bor; Anja Schwiebs; Heinfried Radeke; Monica Hancianu; Oana Cioanca; Ersilia Alexa; Camelia Oprean; Florina Bojin; Codruta Soica; Virgil Paunescu; Cristina Adriana Dehelean
Journal:  Int J Mol Sci       Date:  2018-11-16       Impact factor: 5.923
  6 in total

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