Literature DB >> 26819664

iPSC Neuronal Assay Identifies Amaryllidaceae Pharmacophore with Multiple Effects against Herpesvirus Infections.

James McNulty1, Leonardo D'Aiuto2, Yun Zhi2, Lora McClain3, Carlos Zepeda-Velázquez1, Spencer Ler1, Hilary A Jenkins1, Michael B Yee4, Paolo Piazza5, Robert H Yolken6, Paul R Kinchington4, Vishwajit L Nimgaonkar3.   

Abstract

The Amaryllidaceae alkaloid trans-dihydrolycoricidine 7 and three analogues 8-10 were produced via asymmetric chemical synthesis. Alkaloid 7 proved superior to acyclovir, the current standard for herpes simplex virus, type 1 (HSV-1) infection. Compound 7 potently inhibited lytic HSV-1 infection, significantly reduced HSV-1 reactivation, and more potently inhibited varicella zoster virus (VZV) lytic infection. A configurationally defined (3R)-secondary alcohol at C3 proved crucial for efficacious inhibition of lytic HSV-1 infection.

Entities:  

Keywords:  Amaryllidaceae; HSV-1; Herpesvirus; alkaloid; stem cells; varicella zoster

Year:  2015        PMID： 26819664      PMCID： PMC4716588          DOI： 10.1021/acsmedchemlett.5b00318

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  20 in total

1.  Lycorine: a eukaryotic termination inhibitor?

Authors:  R Vrijsen; D A Vanden Berghe; A J Vlietinck; A Boeyé
Journal:  J Biol Chem       Date:  1986-01-15       Impact factor: 5.157

2.  Biological evaluation of structurally diverse amaryllidaceae alkaloids and their synthetic derivatives: discovery of novel leads for anticancer drug design.

Authors:  Antonio Evidente; Artem S Kireev; Aaron R Jenkins; Anntherese E Romero; Wim F A Steelant; Severine Van Slambrouck; Alexander Kornienko
Journal:  Planta Med       Date:  2009-02-23       Impact factor: 3.352

Review 3.  Glycoprotein targeted therapeutics: a new era of anti-herpes simplex virus-1 therapeutics.

Authors:  Thessicar E Antoine; Paul J Park; Deepak Shukla
Journal:  Rev Med Virol       Date:  2013-02-26       Impact factor: 6.989

4.  Plant antiviral agents. III. Isolation of alkaloids from Clivia miniata Regel (Amaryllidaceae).

Authors:  M Ieven; A J Vlietinck; D A Vanden Berghe; J Totte; R Dommisse; E Esmans; F Alderweireldt
Journal:  J Nat Prod       Date:  1982 Sep-Oct       Impact factor: 4.050

5.  The polyserine tract of herpes simplex virus ICP4 is required for normal viral gene expression and growth in murine trigeminal ganglia.

Authors:  P A Bates; N A DeLuca
Journal:  J Virol       Date:  1998-09       Impact factor: 5.103

6.  Development and pathogenic evaluation of recombinant herpes simplex virus type 1 expressing two fluorescent reporter genes from different lytic promoters.

Authors:  Srividya Ramachandran; Jared E Knickelbein; Christina Ferko; Robert L Hendricks; Paul R Kinchington
Journal:  Virology       Date:  2008-07-11       Impact factor: 3.616

7.  Herpes simplex virus and varicella zoster virus, the house guests who never leave.

Authors:  Paul R Kinchington; Anthony J St Leger; Jean-Marc G Guedon; Robert L Hendricks
Journal:  Herpesviridae       Date:  2012-06-12

8.  Identification of natural compounds with antiviral activities against SARS-associated coronavirus.

Authors:  Shi-You Li; Cong Chen; Hai-Qing Zhang; Hai-Yan Guo; Hui Wang; Lin Wang; Xiang Zhang; Shi-Neng Hua; Jun Yu; Pei-Gen Xiao; Rong-Song Li; Xuehai Tan
Journal:  Antiviral Res       Date:  2005-07       Impact factor: 5.970

9.  Human trophoblasts confer resistance to viruses implicated in perinatal infection.

Authors:  Carolyn B Coyne; Yoel Sadovsky; Avraham Bayer; Elizabeth Delorme-Axford; Christie Sleigher; Teryl K Frey; Derek W Trobaugh; William B Klimstra; Lori A Emert-Sedlak; Thomas E Smithgall; Paul R Kinchington; Stephen Vadia; Stephanie Seveau; Jon P Boyle
Journal:  Am J Obstet Gynecol       Date:  2014-08-06       Impact factor: 10.693

10.  Persistent infection by HSV-1 is associated with changes in functional architecture of iPSC-derived neurons and brain activation patterns underlying working memory performance.

Authors:  Leonardo D'Aiuto; Konasale M Prasad; Catherine H Upton; Luigi Viggiano; Jadranka Milosevic; Giorgio Raimondi; Lora McClain; Kodavali Chowdari; Jay Tischfield; Michael Sheldon; Jennifer C Moore; Robert H Yolken; Paul R Kinchington; Vishwajit L Nimgaonkar
Journal:  Schizophr Bull       Date:  2014-03-12       Impact factor: 9.306
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  5 in total

1.  Comparison of three cell-based drug screening platforms for HSV-1 infection.

Authors:  Leonardo D'Aiuto; Kelly Williamson; Peter Dimitrion; James McNulty; Carla E Brown; Chanti Babu Dokuburra; Alexander J Nielsen; Wen Jing Lin; Paolo Piazza; Mark E Schurdak; Joel Wood; Robert H Yolken; Paul R Kinchington; David C Bloom; Vishwajit L Nimgaonkar
Journal:  Antiviral Res       Date:  2017-03-23       Impact factor: 5.970

2.  R430: A potent inhibitor of DNA and RNA viruses.

Authors:  Leonardo D'Aiuto; James McNulty; Caroll Hartline; Matthew Demers; Raj Kalkeri; Joel Wood; Lora McClain; Ansuman Chattopadhyay; Yun Zhi; Jennifer Naciri; Adam Smith; Robert Yolken; Kodavali Chowdari; Carlos Zepeda-Velazquez; Chanti Babu Dokuburra; Ernesto Marques; Roger Ptak; Paul Kinchington; Simon Watkins; Mark Prichard; David Bloom; Vishwajit Nimgaonkar
Journal:  Sci Rep       Date:  2018-11-09       Impact factor: 4.379

3.  Asymmetric Entry into 10b-aza-Analogues of Amaryllidaceae Alkaloids Reveals a Pronounced Electronic Effect on Antiviral Activity.

Authors:  Carla E Brown; Tiffany Kong; James F Britten; Nick H Werstiuk; James McNulty; Leonardo D'Aiuto; Matthew Demers; Vishwajit L Nimgaonkar
Journal:  ACS Omega       Date:  2018-09-20

4.  Modeling Herpes Simplex Virus 1 Infections in Human Central Nervous System Neuronal Cells Using Two- and Three-Dimensional Cultures Derived from Induced Pluripotent Stem Cells.

Authors:  Leonardo D'Aiuto; David C Bloom; Jennifer N Naciri; Adam Smith; Terri G Edwards; Lora McClain; Jason A Callio; Morgan Jessup; Joel Wood; Kodavali Chowdari; Matthew Demers; Eric E Abrahamson; Milos D Ikonomovic; Luigi Viggiano; Roberta De Zio; Simon Watkins; Paul R Kinchington; Vishwajit L Nimgaonkar
Journal:  J Virol       Date:  2019-04-17       Impact factor: 5.103

5.  Stereoselective synthesis of trans-dihydronarciclasine derivatives containing a 1,4-benzodioxane moiety.

Authors:  Gábor Varró; Balázs Pogrányi; Alajos Grün; András Simon; László Hegedűs; István Kádas
Journal:  Monatsh Chem       Date:  2018-10-26       Impact factor: 1.451
  5 in total

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