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Literature DB >> 2681966

Glomerulosclerosis: are we any wiser?

Abstract

Chronic renal failure (CRF) is characterized histologically by progressive glomerulosclerosis (GS) and tubulo-interstitial scarring (TIS). Recently, research has focused on the study of the pathophysiology of GS. Most advances in this field have been derived from the study of various experimental models of CRF and GS in the rat. In this paper, I will review some of the concepts and hypotheses put forward to explain progressive GS and examine their relevance to glomerular scarring and CRF in humans.

Entities: Disease Species

Mesh：

Year: 1989 PMID： 2681966 DOI： 10.1007/bf01717343

Source DB: PubMed Journal: Klin Wochenschr ISSN： 0023-2173

42 in total

1. Experimentally induced chronic renal insufficiency in the rat.

Authors: A B MORRISON
Journal: Lab Invest Date: 1962-04 Impact factor: 5.662

2. Pharmacologic treatment of hyperlipidemia reduces glomerular injury in rat 5/6 nephrectomy model of chronic renal failure.

Authors: B L Kasiske; M P O'Donnell; W J Garvis; W F Keane
Journal: Circ Res Date: 1988-02 Impact factor: 17.367

3. Prevention of diabetic glomerulopathy by pharmacological amelioration of glomerular capillary hypertension.

Authors: R Zatz; B R Dunn; T W Meyer; S Anderson; H G Rennke; B M Brenner
Journal: J Clin Invest Date: 1986-06 Impact factor: 14.808

4. Renal autoregulation and vulnerability to hypertensive injury in remnant kidney.

Authors: A K Bidani; M M Schwartz; E J Lewis
Journal: Am J Physiol Date: 1987-06

5. Age-dependent glomerulosclerosis and proteinuria occurring in rats of the Milan normotensive strain and not in rats of the Milan hypertensive strain.

Authors: A Brandis; G Bianchi; E Reale; U Helmchen; K Kühn
Journal: Lab Invest Date: 1986-08 Impact factor: 5.662

6. Glomerular injury in uninephrectomized spontaneously hypertensive rats. A consequence of glomerular capillary hypertension.

Authors: L D Dworkin; H D Feiner
Journal: J Clin Invest Date: 1986-03 Impact factor: 14.808

Review 7. Focal and segmental glomerulosclerosis: analogies to atherosclerosis.

Authors: J R Diamond; M J Karnovsky
Journal: Kidney Int Date: 1988-05 Impact factor: 10.612

8. Dietary protein restriction in established renal injury in the rat. Selective role of glomerular capillary pressure in progressive glomerular dysfunction.

Authors: K A Nath; S M Kren; T H Hostetter
Journal: J Clin Invest Date: 1986-11 Impact factor: 14.808