Literature DB >> 26819058

The European Hematology Association Roadmap for European Hematology Research: a consensus document.

Andreas Engert1, Carlo Balduini2, Anneke Brand3, Bertrand Coiffier4, Catherine Cordonnier5, Hartmut Döhner6, Thom Duyvené de Wit7, Sabine Eichinger8, Willem Fibbe3, Tony Green9, Fleur de Haas7, Achille Iolascon10, Thierry Jaffredo11, Francesco Rodeghiero12, Gilles Salles13, Jan Jacob Schuringa14.   

Abstract

The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at €23 billion per year, a level of cost that is not matched in current European hematology research funding. In recent decades, hematology research has improved our fundamental understanding of the biology of blood disorders, and has improved diagnostics and treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap.The EHA Roadmap identifies nine 'sections' in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders.The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients. Copyright© Ferrata Storti Foundation.

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Year:  2016        PMID: 26819058      PMCID: PMC4938336          DOI: 10.3324/haematol.2015.136739

Source DB:  PubMed          Journal:  Haematologica        ISSN: 0390-6078            Impact factor:   9.941


  357 in total

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Journal:  Hum Immunol       Date:  2015-01-27       Impact factor: 2.850

4.  A systems biology approach for defining the molecular framework of the hematopoietic stem cell niche.

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Journal:  Cell Stem Cell       Date:  2014-07-17       Impact factor: 24.633

5.  Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre Stop Imatinib (STIM) trial.

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6.  Incidence of hematologic malignancies in Europe by morphologic subtype: results of the HAEMACARE project.

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Journal:  Blood       Date:  2010-07-27       Impact factor: 22.113

Review 7.  Embryonic origin of the adult hematopoietic system: advances and questions.

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Journal:  Nat Genet       Date:  2013-08-18       Impact factor: 38.330

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  25 in total

1.  Blood disorders stepping into the limelight.

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Journal:  Haematologica       Date:  2016-01-27       Impact factor: 9.941

2.  Noninvasive detection of F8 int22h-related inversions and sequence variants in maternal plasma of hemophilia carriers.

Authors:  Irena Hudecova; Peiyong Jiang; Joanna Davies; Y M Dennis Lo; Rezan A Kadir; Rossa W K Chiu
Journal:  Blood       Date:  2017-05-10       Impact factor: 22.113

Review 3.  Towards the Manufacture of Megakaryocytes and Platelets for Clinical Application.

Authors:  Anja Baigger; Rainer Blasczyk; Constanca Figueiredo
Journal:  Transfus Med Hemother       Date:  2017-05-23       Impact factor: 3.747

4.  Research at the heart of hematology: thrombocytopenias and platelet function disorders.

Authors:  Carlo L Balduini; Federica Melazzini
Journal:  Haematologica       Date:  2017-02       Impact factor: 9.941

5.  Large-scale in vitro production of red blood cells from human peripheral blood mononuclear cells.

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Review 6.  Emerging point-of-care technologies for sickle cell disease screening and monitoring.

Authors:  Yunus Alapan; Arwa Fraiwan; Erdem Kucukal; M Noman Hasan; Ryan Ung; Myeongseop Kim; Isaac Odame; Jane A Little; Umut A Gurkan
Journal:  Expert Rev Med Devices       Date:  2016-11-22       Impact factor: 3.166

7.  The Updated European Hematology Association Research Roadmap.

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Review 8.  Dissecting pharmacological effects of chloroquine in cancer treatment: interference with inflammatory signaling pathways.

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Journal:  Immunology       Date:  2019-12-22       Impact factor: 7.397

9.  Extremely Old Patients Hospitalized in Internal Medicine: What about Their Anemia?

Authors:  Maria Luigia Randi; Irene Bertozzi; Claudia Santarossa; Fabrizio Lucente; Giacomo Biagetti; Fabrizio Fabris
Journal:  Mediterr J Hematol Infect Dis       Date:  2021-05-01       Impact factor: 2.576

10.  A Novel High-Throughput Screening Platform Reveals an Optimized Cytokine Formulation for Human Hematopoietic Progenitor Cell Expansion.

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Journal:  Stem Cells Dev       Date:  2016-09-30       Impact factor: 3.272

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