| Literature DB >> 26818609 |
Etan Orgel1,2,3, Nicole M Mueske4, Richard Sposto1,3, Vicente Gilsanz5, David R Freyer1,3, Steven D Mittelman3,6.
Abstract
Obesity as defined by body mass index percentile (BMI%) is strongly associated with relapse and poorer survival in childhood ALL. Whether BMI% accurately reflects body fat percentage (BF%) in this population is unknown. We conducted a prospective study assessing body composition during frontline ALL therapy. Dual-energy X-ray absorptiometry measured BF% and lean muscle mass (LMM) at diagnosis, end of Induction, and end of Delayed Intensification. Sarcopenic obesity (gain in BF% with loss of LMM) was surprisingly common during ALL treatment, resulting in poor correlation between changes in BMI% (expressed as Z-score) and BF% overall (r = -0.05) and within patients (r = -0.09). BMI Z-score and BF% changed in opposite directions in >50% of interval assessments. While BMI% at diagnosis is a suitable predictor of obesity/BF% for epidemiological studies, change in BMI% (as expressed as Z-score) does not reflect body composition. Studies evaluating obesity in leukemia should consider using direct measures of body composition.Entities:
Keywords: Adiposity; DXA scan; body fat; body mass index; childhood ALL; obesity
Mesh：
Year: 2016 PMID： 26818609 PMCID： PMC5362342 DOI： 10.3109/10428194.2015.1136741
Source DB: PubMed Journal: Leuk Lymphoma ISSN： 1026-8022