Francesco Giallauria1, Pasquale Predotti2, Antonio Casciello3, Alessandra Grieco1, Angelo Russo1, Anna Viggiano2, Rodolfo Citro2, Amelia Ravera2, Maurizio Ciardo4, Michele Guglielmi3, Marcello Maggio5, Carlo Vigorito1. 1. a Department of Translational Medical Sciences. Division of Internal Medicine and Cardiac Rehabilitation , "Federico II" University , Naples , Italy . 2. b Hypertenion Care Unit; "S. Giovanni di Dio e Ruggi d'Aragona" Hospital , Salerno , Italy . 3. c Division of Cardiology; "Casa di Cura Tortorella" , Salerno , Italy . 4. d Critical Care Unit; "Ignazio Veris Delli Ponti" Hospital , Scorrano , Italy , and. 5. e Department of Clinical and Experimental Medicine , Section of Geriatrics, University of Parma , Italy.
Abstract
BACKGROUND: We aimed at evaluating the relationship between the circadian blood pressure rhythm and UA level in young patients (30-40 years old) with newly diagnosed essential hypertension. METHODS: The study included 62 essential hypertensive patients and 29 healthy controls (20 men, 35 ± 3 years) divided into two groups according to 24-hour ABPM results: 30 dippers and 32 nondippers. RESULTS: Nondippers showed significantly higher both serum UA levels compared to dippers and controls (6.1 ± 0.7, 5.2 ± 0.9 and 4.1 ± 0.9 mg/dL, p < 0.001, respectively); and high sensitivity C-reactive protein (hsCRP) (4.1 ± 2.2 mg/L, 3.3 ± 1.9 mg/L, and 1.4 ± 0.9 mg/L, p < 0.001, respectively). After adjusting for age, sex, body mass index, smoking, creatinine levels, hsCRP and comorbidity, multivariate logistic regression analysis revealed an independent association between serum UA levels and nondipper pattern (OR 2.44, 95%CIs 1.4-4.1, p = 0.002). CONCLUSION: Serum UA is independently associated with nondipper circadian pattern in young patients with newly diagnosed essential hypertension.
BACKGROUND: We aimed at evaluating the relationship between the circadian blood pressure rhythm and UA level in young patients (30-40 years old) with newly diagnosed essential hypertension. METHODS: The study included 62 essential hypertensivepatients and 29 healthy controls (20 men, 35 ± 3 years) divided into two groups according to 24-hour ABPM results: 30 dippers and 32 nondippers. RESULTS: Nondippers showed significantly higher both serum UA levels compared to dippers and controls (6.1 ± 0.7, 5.2 ± 0.9 and 4.1 ± 0.9 mg/dL, p < 0.001, respectively); and high sensitivity C-reactive protein (hsCRP) (4.1 ± 2.2 mg/L, 3.3 ± 1.9 mg/L, and 1.4 ± 0.9 mg/L, p < 0.001, respectively). After adjusting for age, sex, body mass index, smoking, creatinine levels, hsCRP and comorbidity, multivariate logistic regression analysis revealed an independent association between serum UA levels and nondipper pattern (OR 2.44, 95%CIs 1.4-4.1, p = 0.002). CONCLUSION: Serum UA is independently associated with nondipper circadian pattern in young patients with newly diagnosed essential hypertension.
Authors: Laura G Sanchez-Lozada; Bernardo Rodriguez-Iturbe; Eric E Kelley; Takahiko Nakagawa; Magdalena Madero; Dan I Feig; Claudio Borghi; Federica Piani; Gabriel Cara-Fuentes; Petter Bjornstad; Miguel A Lanaspa; Richard J Johnson Journal: Am J Hypertens Date: 2020-07-18 Impact factor: 3.080