OBJECTIVES: The aim of our study was to determine if redox imbalance caused by the activities of antioxidant enzymes existed in erythrocytes of type 1 myotonic dystrophy (DM1) patients. METHODS: The activities of erythrocyte superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase were measured in 30 DM1 patients and 15 healthy controls (HCs). The obtained values were correlated with the Muscular Impairment Rating Scale (MIRS) score and creatine kinase (CK). RESULTS: Superoxide dismutase and catalase activities were lower in DM1 patients compared to HCs. A positive correlation was found between disease duration and MIRS score as well as with glutathione reductase activity. In DM1 patients, there were positive correlations between catalase, glutathione peroxidase, and glutathione reductase activities. After sub-dividing DM1 patients according to CK levels, superoxide dismutase activity was still statistically different from HCs. However, catalase activity was significantly lower only in DM1 patients with increased CK. DISCUSSION: Undesirable alterations in antioxidant enzyme activities during DM1 disease progression may result in conditions favoring oxidative stress and changes in metabolism which together could contribute to muscle wasting.
OBJECTIVES: The aim of our study was to determine if redox imbalance caused by the activities of antioxidant enzymes existed in erythrocytes of type 1 myotonic dystrophy (DM1) patients. METHODS: The activities of erythrocyte superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase were measured in 30 DM1 patients and 15 healthy controls (HCs). The obtained values were correlated with the Muscular Impairment Rating Scale (MIRS) score and creatine kinase (CK). RESULTS:Superoxide dismutase and catalase activities were lower in DM1 patients compared to HCs. A positive correlation was found between disease duration and MIRS score as well as with glutathione reductase activity. In DM1 patients, there were positive correlations between catalase, glutathione peroxidase, and glutathione reductase activities. After sub-dividing DM1 patients according to CK levels, superoxide dismutase activity was still statistically different from HCs. However, catalase activity was significantly lower only in DM1 patients with increased CK. DISCUSSION: Undesirable alterations in antioxidant enzyme activities during DM1 disease progression may result in conditions favoring oxidative stress and changes in metabolism which together could contribute to muscle wasting.
Authors: F McArdle; S Spiers; H Aldemir; A Vasilaki; A Beaver; L Iwanejko; A McArdle; M J Jackson Journal: J Physiol Date: 2004-08-26 Impact factor: 5.182
Authors: Y Ihara; A Mori; T Hayabara; R Namba; K Nobukuni; K Sato; S Miyata; R Edamatsu; J Liu; M Kawai Journal: J Neurol Date: 1995-02 Impact factor: 4.849
Authors: Eva Alegre-Cortés; Alberto Giménez-Bejarano; Elisabet Uribe-Carretero; Marta Paredes-Barquero; André R A Marques; Mafalda Lopes-da-Silva; Otília V Vieira; Saray Canales-Cortés; Pedro J Camello; Guadalupe Martínez-Chacón; Ana Aiastui; Roberto Fernández-Torrón; Adolfo López de Munain; Patricia Gomez-Suaga; Mireia Niso-Santano; Rosa A González-Polo; José M Fuentes; Sokhna M S Yakhine-Diop Journal: Cells Date: 2022-09-27 Impact factor: 7.666
Authors: Sylvia Nieuwenhuis; Joanna Widomska; Paul Blom; Peter-Bram A C 't Hoen; Baziel G M van Engelen; Jeffrey C Glennon Journal: Int J Mol Sci Date: 2022-03-12 Impact factor: 5.923