OBJECTIVE: To assess the effect of treatment with a combination of the antiestrogen Tamoxifen citrate and Folate on semen quality of the infertile male with semen abnormality. DESIGN: Prospective randomized controlled trial study. MATERIAL AND METHOD:Between May 2013 and October 2014, 68 infertile male with semen abnormality were asked to join the present study. Informed consents were signed; all patients were divided into four groups, given placebo (control), Tamoxifen citrate 20 mg/day, Folate 5 mg/day, and Tamoxifen citrate plus Folate for continuous three months. The result of treatments i.e., semen parameters, hyaluronan binding assay, hypo-osmotic swelling test, and DNA damage test were evaluated at baseline, at the end of drugs treatment (3-month), and at 3-month after discontinuation of treatment (6-month). RESULTS:Tamoxifen alone caused a significant increase in sperm concentration, while Tamoxifen plus Folate significantly increased both sperm concentration and sperm motility at 3-month after treatment. Folate alone and Tamoxifen plus Folate significantly decreased DNA tail length at 3-month and at 3- and 6-month after treatment, whereas Tamoxifen alone caused no significant change in DNA tail length. Sperm DNA integrity was improved as seen by decrease in the length ofDNA tail. CONCLUSION: Our study indicated that Folate in combination with Tamoxifen citrate could improve sperm quality including semen parameters and sperm DNA integrity.
RCT Entities:
OBJECTIVE: To assess the effect of treatment with a combination of the antiestrogen Tamoxifen citrate and Folate on semen quality of the infertile male with semen abnormality. DESIGN: Prospective randomized controlled trial study. MATERIAL AND METHOD: Between May 2013 and October 2014, 68 infertile male with semen abnormality were asked to join the present study. Informed consents were signed; all patients were divided into four groups, given placebo (control), Tamoxifen citrate 20 mg/day, Folate 5 mg/day, and Tamoxifen citrate plus Folate for continuous three months. The result of treatments i.e., semen parameters, hyaluronan binding assay, hypo-osmotic swelling test, and DNA damage test were evaluated at baseline, at the end of drugs treatment (3-month), and at 3-month after discontinuation of treatment (6-month). RESULTS:Tamoxifen alone caused a significant increase in sperm concentration, while Tamoxifen plus Folate significantly increased both sperm concentration and sperm motility at 3-month after treatment. Folate alone and Tamoxifen plus Folate significantly decreased DNA tail length at 3-month and at 3- and 6-month after treatment, whereas Tamoxifen alone caused no significant change in DNA tail length. Sperm DNA integrity was improved as seen by decrease in the length ofDNA tail. CONCLUSION: Our study indicated that Folate in combination with Tamoxifen citrate could improve sperm quality including semen parameters and sperm DNA integrity.
Authors: Wiep de Ligny; Roos M Smits; Rebecca Mackenzie-Proctor; Vanessa Jordan; Kathrin Fleischer; Jan Peter de Bruin; Marian G Showell Journal: Cochrane Database Syst Rev Date: 2022-05-04
Authors: Roos M Smits; Rebecca Mackenzie-Proctor; Anusch Yazdani; Marcin T Stankiewicz; Vanessa Jordan; Marian G Showell Journal: Cochrane Database Syst Rev Date: 2019-03-14
Authors: Jeffrey Hoek; Régine P M Steegers-Theunissen; Sten P Willemsen; Sam Schoenmakers Journal: Mol Nutr Food Res Date: 2020-02-20 Impact factor: 5.914
Authors: Anastasiia D Shcherbitskaia; Evgeniia M Komarova; Yulia P Milyutina; Mariia A Ishchuk; Yanina M Sagurova; Galina K Safaryan; Elena A Lesik; Alexander M Gzgzyan; Olesya N Bespalova; Igor Y Kogan Journal: Int J Mol Sci Date: 2022-09-02 Impact factor: 6.208