In situ urethroplasty after artificial urinary sphincter cuff erosion.

Artificial urinary sphincter (AUS) cuff erosion is a challenging complication traditionally managed with device removal and Foley catheter drainage. Urethral stricture can result secondary to the healing process, delaying AUS reimplantation. In situ urethroplasty (ISU) technique is a definitive repair at the time of device removal. Early results demonstrate a decreased rate of stricture formation compared to traditional management with little additional operative time and no additional complications. Patients undergoing ISU have less delay prior to AUS reimplantation, leading to possible benefit in health-related quality of life (HRQL) outcomes.

Introduction

The artificial urinary sphincter (AUS) has evolved from its original description by Scott, over 40 years ago (1). Innovative treatments such as the male sling (2) and injectable agents (3) have been described; however, the AUS remains the gold standard for treatment of male stress urinary incontinence (SUI), with long-term safety and efficacy.

Short-term complications with AUS placement are rare; however large, long-term series have reported complication rates between 16-31% (4-8) with revision in up to 53-64% of cases (9,10). In particular, urethral cuff erosion remains a troublesome complication, occurring in 4.2-6.1% of patients (4-10). Traditional management of AUS cuff erosion consists of device removal with urinary diversion via Foley catheter placement or suprapubic cystostomy for several weeks (11). Further complicating the clinical course of an AUS cuff erosion is the urethral stricture formation during secondary healing of the urethral defect. Though not well reported, urethral stricture development in the AUS patient is a vexing problem requiring further manipulation such as dilation or incision/excision of the stricture prior to AUS replacement, if and when that ever becomes possible.

In situ urethroplasty (ISU) technique has recently been reported at the time of eroded cuff removal to prevent urethral stricture development (12). In this article we will review AUS cuff erosion and its risk factors, describe the ISU technique and discuss the benefits of ISU in these challenging patients.

Risk factors for AUS cuff erosion

Urethral erosion occurs in 4.2-6.1% of AUS cases, and although preventive measures such as delayed activation and overnight deactivation have been proposed over the past 20 years, AUS cuff erosion remains a troublesome complication (4-10,13). Multiple patient associated factors (smoking, coronary artery disease, obesity, hypertension, diabetes mellitus) have been linked to AUS complications (10,14). In particular, pelvic radiation, and its attendant obliterative endarteritis, has been shown to have a profound effect on cuff erosion rates (14-16). Likewise, AUS revision surgery has been associated with a higher cuff erosion rate, especially in those with a history of prior infection or erosion of the device (14-17).

Recently, the introduction of the smaller 3.5 cm cuff has provided incontinence surgeons a solution for small caliber urethras with positive initial results (18). It is possible, however, that cuff erosions may occur more commonly with use of the smaller 3.5 cm cuffs (16), especially in the high risk patient (19). Finally, neurogenic bladder patients have historically been shown to be at higher risk for AUS complications, including erosion (20), however more recent data would indicate that comparable outcomes are achievable in this population (8).

ISU technique

ISU is performed at the time of AUS device explantation. shows an endoscopic view of the eroded AUS cuff. After the cuff is removed, Foley catheter is inserted to facilitate reconstruction, and when necessary, urethroscopy with wire placement ensures accurate placement of a 14-French Council tip catheter (). ISU is accomplished by reapproximating the urethral defect with full-thickness, interrupted 2-0 absorbable monofilament suture over the catheter ( and ). This abbreviated approach is performed without further mobilization of inflamed tissues within the already hostile operative field. The urethral Foley catheter is left in place for three weeks with voiding cystourethrogram (VCUG) imaging done at the time of removal.

Figure 1

An endoscopic view of AUS cuff erosion. AUS, artificial urinary sphincter.

Figure 2

Intra-operative view of urethral erosion defect, with Foley catheter exposed.

Figure 3

Illustration of ISU technique using 2-0 abosorbable monofilament suture to reapproximate ventral urethral erosion defect. ISU, in situ urethroplasty.

Figure 4

Intra-operative view of ISU technique using 2-0 abosorbable monofilament suture to reapproximate ventral urethral erosion defect. ISU, in situ urethroplasty.

Results of ISU

Rozanski and colleagues examined the primary outcome of stricture formation after cuff erosion in two cohorts, those undergoing ISU at the time of cuff removal and those managed with traditional Foley catheter drainage after removal (12). The 26 patients in the two groups were well matched for age and comorbidities. ISU patients had a dramatically lower rate of stricture formation (5/13, 38%) compared to 11/13 (85%) in the traditional management group (P=0.047). Performing the ISU did not add significant time to the operative procedure, averaging an additional 8 minutes.

Patients undergoing an ISU received significantly fewer interim procedures prior to device replacement and had a higher chance of eventually receiving a subsequent AUS reimplantation surgery. ISU also decreased delay in AUS replacement, with an average interval of 9 months compared to 17 months. No patient who underwent secondary AUS implantation surgery experienced subsequent erosion over a mean follow-up interval of 24 months.

It was noted that most men who develop strictures following AUS cuff removal never have the device replaced, thus continuing to suffer from severe urinary incontinence. Re-establishing continence in these patients as soon as possible is of paramount importance because incontinent men experience significant reduction in their health-related quality of life (HRQL) (21,22). Incontinence, however mild, is associated with lifestyle modification, loss of work, social embarrassment, and an increased risk of hospitalization and nursing home admission (23,24). Treatment to restore continence should be as expeditious as possible to return them to normal activities. Resultant urethral strictures delay AUS replacement, subjecting patients to interval procedures, further magnifying the devastating sequelae of incontinence.

Advantages and limitations of ISU

ISU appears to be an expeditious, yet definitive repair, adding little operative time to AUS removal, with negligible complications related to ISU. Stricture formation with ISU as compared with traditional management with Foley catheter drainage alone is considerably lower. Finally, ISU patients usually had a new AUS implanted without further delay or additional procedures. Though quality of life has not specifically been compared, it is likely that ISU patients benefit by an earlier return to a better HRQL. The short follow-up in a small series of patients at a single institution, makes this technique less generalizable. Larger series, in a diverse population with similar results will gain this technique broader acceptance.

Conclusions

ISU offers promising results in the prevention of urethral stricture formation after AUS cuff erosion. The time to AUS reimplantation may be reduced compared to traditional management.