| Literature DB >> 26816396 |
Wenyi Qin1, Guijun Zhao2, Matthew Carson1, Caiyan Jia3, Hui Lu4.
Abstract
A structure-based statistical potential is developed for transcription factor binding site (TFBS) prediction. Besides the direct contact between amino acids from TFs and DNA bases, the authors also considered the influence of the neighbouring base. This three-body potential showed better discriminate powers than the two-body potential. They validate the performance of the potential in TFBS identification, binding energy prediction and binding mutation prediction.Entities:
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Year: 2016 PMID: 26816396 PMCID: PMC8687219 DOI: 10.1049/iet-syb.2014.0066
Source DB: PubMed Journal: IET Syst Biol ISSN: 1751-8849 Impact factor: 1.615