Chiharu Matsuda1,2, Toshio Shimizu3, Yuki Nakayama1, Michiko Haraguchi1, Chiyoko Hakuta4, Yumi Itagaki1, Akiko Ogura1, Kanako Murata5, Masato Taira6,7, Takaya Numayama8, Masanobu Kinoshita2. 1. ALS Nursing Care Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, Japan. 2. Department of Frontier Health Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan. 3. Department of Neurology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan. 4. Department of Preventive Oral Health Care Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan. 5. Department of Nursing, School of Nursing and Rehabilitation Sciences, Showa University, Kanagawa, Japan. 6. Department of Cognitive Neurobiology Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan. 7. Center for Brain Integration Research, Tokyo, Japan. 8. Department of Neurology, Sayama Neurological Hospital, Saitama, Japan.
Abstract
INTRODUCTION: An enlarged tongue (macroglossia) has been reported in advanced-stage patients with amyotrophic lateral sclerosis (ALS). METHODS: In this study we examined the prevalence of macroglossia and analyzed clinical correlations in 65 ALS patients on tracheostomy-invasive ventilation (TIV). RESULTS: Macroglossia was found in 22 patients (33.8%). Compared with those without macroglossia, patients with macroglossia had a younger age of onset, longer duration of disease and TIV use, lower ALS Functional Rating Scale score, higher body mass index, lower energy intake, more severe communication impairment, and lower oral function. Logistic multivariate analysis showed that body mass index (BMI; P = 0.007) and communication impairment (P = 0.029) were significantly correlated with macroglossia. The duration of TIV use was at the cut-off level of significance (P = 0.05). CONCLUSIONS: Macroglossia may be the result of overfeeding and replacement by fat during long-term TIV use in patients with advanced ALS. Muscle Nerve, 2016 Muscle Nerve 54: 386-390, 2016.
INTRODUCTION: An enlarged tongue (macroglossia) has been reported in advanced-stage patients with amyotrophic lateral sclerosis (ALS). METHODS: In this study we examined the prevalence of macroglossia and analyzed clinical correlations in 65 ALSpatients on tracheostomy-invasive ventilation (TIV). RESULTS:Macroglossia was found in 22 patients (33.8%). Compared with those without macroglossia, patients with macroglossia had a younger age of onset, longer duration of disease and TIV use, lower ALS Functional Rating Scale score, higher body mass index, lower energy intake, more severe communication impairment, and lower oral function. Logistic multivariate analysis showed that body mass index (BMI; P = 0.007) and communication impairment (P = 0.029) were significantly correlated with macroglossia. The duration of TIV use was at the cut-off level of significance (P = 0.05). CONCLUSIONS:Macroglossia may be the result of overfeeding and replacement by fat during long-term TIV use in patients with advanced ALS. Muscle Nerve, 2016 Muscle Nerve 54: 386-390, 2016.
Authors: Berthe A M Makizodila; Johanna H E van de Wijdeven; Johannes J de Soet; Maurits K A van Selms; Catherine M C Volgenant Journal: Spec Care Dentist Date: 2021-07-26