Hikmet Gulsah Tanyildiz1, Emel Cabi Unal2, Hafize Gokce2, Gulsan Yavuz2, Nurdan Tacyildiz2, Handan Dincaslan2, Ceyda Gurman2, Zeynep Biyikli3. 1. Division of Pediatric Hematology/Oncology, Cebeci Medical Faculty Ankara, Ankara University, Ankara, Turkey. g_oktay4910@yahoo.com. 2. Division of Pediatric Hematology/Oncology, Cebeci Medical Faculty Ankara, Ankara University, Ankara, Turkey. 3. Division of Biostatistics, Cebeci Medical Faculty Ankara, Ankara University, Ankara, Turkey.
Abstract
OBJECTIVES: To determine serum levels of basic fibroblastic growth factor (b-FGF) in hemangioma patients under 2 y of age. METHODS: The study group consisted of 43 children with infantile hemangioma and b-FGF levels were analyzed using ELISA. RESULTS: The serum b-FGF levels were higher in hemangioma patients than in healthy control individuals (p 0.01). There were no differences between the lesion size, number of lesions, patient age and serum b-FGF levels. CONCLUSIONS: Thus, b-FGF is an important growth factor that plays a central role in hemangioma, but determining b-FGF serum levels was not helpful in distinguishing between patients who require treatment and those who do not.
OBJECTIVES: To determine serum levels of basic fibroblastic growth factor (b-FGF) in hemangiomapatients under 2 y of age. METHODS: The study group consisted of 43 children with infantile hemangioma and b-FGF levels were analyzed using ELISA. RESULTS: The serum b-FGF levels were higher in hemangiomapatients than in healthy control individuals (p 0.01). There were no differences between the lesion size, number of lesions, patient age and serum b-FGF levels. CONCLUSIONS: Thus, b-FGF is an important growth factor that plays a central role in hemangioma, but determining b-FGF serum levels was not helpful in distinguishing between patients who require treatment and those who do not.
Authors: Mark E Kleinman; Matthew R Greives; Samara S Churgin; Keith M Blechman; Eric I Chang; Daniel J Ceradini; Oren M Tepper; Geoffrey C Gurtner Journal: Arterioscler Thromb Vasc Biol Date: 2007-09-13 Impact factor: 8.311
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