Literature DB >> 26815929

Intravitreal bevacizumab and feeder vessel laser treatment for a posteriorly located retinal capillary hemangioma.

Aniruddha Agarwal1, Neha Kumari2, Ramandeep Singh3.   

Abstract

Retinal capillary hemangioma (RCH) is strongly associated with von Hippel-Lindau (VHL) disease. Treatment of this sight-threatening condition is often unsatisfactory despite multiple treatment options available. We here describe an interesting case of a 50-year-old male with RCH located in the perifoveal region of the left eye. Subretinal bleed, exudation, and macular edema resulted in progressive deterioration of visual acuity. Fundus photography, fluorescein angiography, and optical coherence tomography (OCT) were used to serially monitor the lesion. After ruling out systemic lesions of VHL disease, the patient was subjected to direct laser photocoagulation of the lesion which resulted in further loss in vision with increase in bleed and exudation. Subsequently, the patient was given 2 monthly intravitreal injections of bevacizumab followed by laser photocoagulation of feeder arteriole. This combination therapy resulted in resolution of exudation, bleed, and macular edema with improvement in visual acuity. Thus, vision-threatening RCH may be safely and effectively treated by means of a combination therapy comprising of intravitreal bevacizumab and feeder vessel treatment.

Entities:  

Keywords:  Anti-VEGF; Feeder vessel therapy; Laser photocoagulation; Retinal capillary hemangioma; von Hippel–Lindau disease

Mesh:

Substances:

Year:  2016        PMID: 26815929     DOI: 10.1007/s10792-016-0183-x

Source DB:  PubMed          Journal:  Int Ophthalmol        ISSN: 0165-5701            Impact factor:   2.031


  19 in total

1.  Juxtapapillary capillary hemangiomas. Clinical features and visual acuity outcomes.

Authors:  C M McCabe; H W Flynn; C L Shields; J A Shields; C D Regillo; H R McDonald; M H Berrocal; J D Gass; W F Mieler
Journal:  Ophthalmology       Date:  2000-12       Impact factor: 12.079

2.  Systemic bevacizumab treatment of a juxtapapillary retinal haemangioma.

Authors:  Maximilian von Buelow; Stefanie Pape; Hans Hoerauf
Journal:  Acta Ophthalmol Scand       Date:  2007-02

3.  Direct and feeder vessel photocoagulation of retinal angiomas with dye yellow laser.

Authors:  C F Blodi; S R Russell; J S Pulido; J C Folk
Journal:  Ophthalmology       Date:  1990-06       Impact factor: 12.079

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Authors:  D B Archer; A Deutman; J T Ernest; A E Krill
Journal:  Am J Ophthalmol       Date:  1973-02       Impact factor: 5.258

5.  Response of retinal capillary hemangioma to cryotherapy.

Authors:  J A Shields
Journal:  Arch Ophthalmol       Date:  1993-04

6.  Three cases of large retinal capillary hemangiomas treated with verteporfin and photodynamic therapy.

Authors:  Thomas M Aaberg; Thomas M Aaberg; Daniel F Martin; James P Gilman; Robert Myles
Journal:  Arch Ophthalmol       Date:  2005-03

7.  Rapid and durable recovery of visual function in a patient with von hippel-lindau syndrome after systemic therapy with vascular endothelial growth factor receptor inhibitor su5416.

Authors:  Lloyd Paul Aiello; Daniel J George; Mark T Cahill; Jun S Wong; Jerry Cavallerano; Alison L Hannah; William G Kaelin
Journal:  Ophthalmology       Date:  2002-09       Impact factor: 12.079

8.  Benefits and complications of photodynamic therapy of papillary capillary hemangiomas.

Authors:  Ursula M Schmidt-Erfurth; Christine Kusserow; Irene A Barbazetto; Horst Laqua
Journal:  Ophthalmology       Date:  2002-07       Impact factor: 12.079

9.  Von Hippel-Lindau disease: the recognition and treatment of early angiomatosis retinae and the use of cryosurgery as an adjunct to therapy.

Authors:  R B Welch
Journal:  Trans Am Ophthalmol Soc       Date:  1970

10.  Clinical characterization of retinal capillary hemangioblastomas in a large population of patients with von Hippel-Lindau disease.

Authors:  Wai T Wong; Elvira Agrón; Hanna R Coleman; Tam Tran; George F Reed; Karl Csaky; Emily Y Chew
Journal:  Ophthalmology       Date:  2007-06-01       Impact factor: 12.079

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  5 in total

1.  Retinal arteriolar macroaneurysm associated with congenital retinal macro vessel.

Authors:  Vinod Kumar; Neha Goel
Journal:  Int Ophthalmol       Date:  2019-02       Impact factor: 2.031

2.  Pazopanib in patients with von Hippel-Lindau disease: a single-arm, single-centre, phase 2 trial.

Authors:  Eric Jonasch; Ian E McCutcheon; Dan S Gombos; Kamran Ahrar; Nancy D Perrier; Diane Liu; Christine C Robichaux; Mercedes F Villarreal; Justin A Weldon; Ashley H Woodson; Patrick G Pilie; Gregory N Fuller; Steven G Waguespack; Surena F Matin
Journal:  Lancet Oncol       Date:  2018-09-17       Impact factor: 41.316

3.  Combined therapy guided by multimodal imaging of fifteen retinal capillary hemangioblastomas in a monocular Von Hippel- Lindau syndrome case report.

Authors:  Ju Guo; Liping Du; Pengyi Zhou; Xiaohong Guo; Fangfang Dai; Xuemin Jin
Journal:  BMC Ophthalmol       Date:  2022-05-06       Impact factor: 2.086

Review 4.  Von Hippel-Lindau Disease and the Eye.

Authors:  Saeed Karimi; Amir Arabi; Toktam Shahraki; Sare Safi
Journal:  J Ophthalmic Vis Res       Date:  2020-02-02

5.  REPAIR OF COMBINED TRACTION-RHEGMATOGENOUS RETINAL DETACHMENT AFTER CRYOABLATION OF A RETINAL CAPILLARY HEMANGIOBLASTOMA.

Authors:  Philip J DeSouza; Craig M Greven
Journal:  Retin Cases Brief Rep       Date:  2022-03-01
  5 in total

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