| Literature DB >> 26815656 |
Jinquan Chen, Ruxia Ren, Suiyi Tan, Wanyue Zhang, Xuanxuan Zhang, Fei Yu, Tianrong Xun, Shibo Jiang, Shuwen Liu, Lin Li.
Abstract
Entities:
Year: 2016 PMID: 26815656 PMCID: PMC4729527 DOI: 10.1371/journal.pone.0147679
Source DB: PubMed Journal: PLoS One ISSN: 1932-6203 Impact factor: 3.240
Fig 7Schematic representation of EP2’s mechanism in promoting PAP248-286 amyloid fibril formation and enhancing HIV-1 infection.
(A) PAP248-286 amyloid fibrils enhanced HIV-1 infection. Under agitation at 37°C, PAP248-286 slowly (~ 24 h) formed amyloid fibrils, which enhanced HIV-1 infection. (B) EP2 promoted the formation of PAP248-286 amyloid fibrils. Without agitation, EP2 rapidly (~ 1 min) self-assembled into nanofibers. These nanofibers accelerated (~ 4 h) the formation of amyloid fibrils, which enhanced HIV-1 infection.