Literature DB >> 268155

Hemoglobin E and glucose-6-phosphate deficiency in the Khmer Air Force (Cambodia).

W D Everett, A Yoshida, E Pearlman.   

Abstract

This study was designed to investigate the use of primaquine in malaria control in the Khmer Republic (Cambodia). Blood was drawn from 106 male Khmer Air Force troops for analysis of hemoglobin E and glucose-6-phosphate (G-6-PD) deficiency. A test group of 15 men with G-6-PD deficiency and a group of 31 normal controls were given 15 mg of primaquine each morning for 14 days. The patients were followed for hemoglobinuria and changes in hematocrit. Primaquine induced a significant, but not a dangerous, hemolysis in G-6pD-deficient Khmer troops. The G-6-PD deficiency seen in Khmer Air Force subjects was G-6-PD Mahidol. Statistically, G-6-PD Mahidol was linked to hemoglobin E.

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Year:  1977        PMID： 268155     DOI： 10.4269/ajtmh.1977.26.597

Source DB:  PubMed          Journal:  Am J Trop Med Hyg        ISSN： 0002-9637            Impact factor:   2.345


  10 in total

1.  Glucose-6-phosphate dehydrogenase (G6PD) mutations in Cambodia: G6PD Viangchan (871G>A) is the most common variant in the Cambodian population.

Authors:  Hiroyuki Matsuoka; Chea Nguon; Toshio Kanbe; Amadu Jalloh; Hiroko Sato; Shigeto Yoshida; Makoto Hirai; Meiji Arai; Duong Socheat; Fumihiko Kawamoto
Journal:  J Hum Genet       Date:  2005-09-01       Impact factor: 3.172

Review 2.  Primaquine: the risks and the benefits.

Authors:  Elizabeth A Ashley; Judith Recht; Nicholas J White
Journal:  Malar J       Date:  2014-11-03       Impact factor: 2.979

3.  Field trial evaluation of the performances of point-of-care tests for screening G6PD deficiency in Cambodia.

Authors:  Arantxa Roca-Feltrer; Nimol Khim; Saorin Kim; Sophy Chy; Lydie Canier; Alexandra Kerleguer; Pety Tor; Char Meng Chuor; Sim Kheng; Sovannaroth Siv; Patrick S Kachur; Walter R J Taylor; Jimee Hwang; Didier Menard
Journal:  PLoS One       Date:  2014-12-26       Impact factor: 3.240

4.  An optimised age-based dosing regimen for single low-dose primaquine for blocking malaria transmission in Cambodia.

Authors:  Rithea Leang; Naw Htee Khu; Mavuto Mukaka; Mark Debackere; Rupam Tripura; Soy Ty Kheang; Say Chy; Neeraj Kak; Philippe Buchy; Arnaud Tarantola; Didier Menard; Arantxa Roca-Felterer; Rick M Fairhurst; Sim Kheng; Sinoun Muth; Song Ngak; Arjen M Dondorp; Nicholas J White; Walter Robert John Taylor
Journal:  BMC Med       Date:  2016-10-27       Impact factor: 8.775

5.  Modelling primaquine-induced haemolysis in G6PD deficiency.

Authors:  James Watson; Walter Rj Taylor; Didier Menard; Sim Kheng; Nicholas J White
Journal:  Elife       Date:  2017-02-04       Impact factor: 8.140

6.  Systematic review of the clinical manifestations of glucose-6-phosphate dehydrogenase deficiency in the Greater Mekong Subregion: implications for malaria elimination and beyond.

Authors:  Ken Ing Cherng Ong; Hodaka Kosugi; Sophea Thoeun; Hitomi Araki; Moe Moe Thandar; Moritoshi Iwagami; Bouasy Hongvanthong; Paul T Brey; Shigeyuki Kano; Masamine Jimba
Journal:  BMJ Glob Health       Date:  2017-08-19

7.  The tolerability of single low dose primaquine in glucose-6-phosphate deficient and normal falciparum-infected Cambodians.

Authors:  Lek Dysoley; Saorin Kim; Sergio Lopes; Nimol Khim; Steven Bjorges; Samphornarann Top; Chea Huch; Huy Rekol; Nelli Westercamp; Mark M Fukuda; Jimee Hwang; Arantxa Roca-Feltrer; Mavuto Mukaka; Didier Menard; Walter R Taylor
Journal:  BMC Infect Dis       Date:  2019-03-12       Impact factor: 3.090

8.  G6PD deficiency in Plasmodium falciparum and Plasmodium vivax malaria-infected Cambodian patients.

Authors:  Nimol Khim; Christophe Benedet; Saorin Kim; Sim Kheng; Sovannaroth Siv; Rithea Leang; Soley Lek; Sinuon Muth; Nguon Chea; Char Meng Chuor; Socheat Duong; Alexandra Kerleguer; Pety Tor; Pheaktra Chim; Lydie Canier; Benoit Witkowski; Walter R J Taylor; Didier Ménard
Journal:  Malar J       Date:  2013-05-28       Impact factor: 2.979

9.  Tolerability and safety of weekly primaquine against relapse of Plasmodium vivax in Cambodians with glucose-6-phosphate dehydrogenase deficiency.

Authors:  Sim Kheng; Sinoun Muth; Walter R J Taylor; Narann Tops; Khem Kosal; Khon Sothea; Phum Souy; Saorin Kim; Chuor Meng Char; Chan Vanna; Po Ly; Pascal Ringwald; Virak Khieu; Alexandra Kerleguer; Pety Tor; John K Baird; Steven Bjorge; Didier Menard; Eva Christophel
Journal:  BMC Med       Date:  2015-08-25       Impact factor: 8.775

10.  Efficacy of two versus three-day regimens of dihydroartemisinin-piperaquine for uncomplicated malaria in military personnel in northern Cambodia: an open-label randomized trial.

Authors:  Chanthap Lon; Jessica E Manning; Pattaraporn Vanachayangkul; Mary So; Darapiseth Sea; Youry Se; Panita Gosi; Charlotte Lanteri; Suwanna Chaorattanakawee; Sabaithip Sriwichai; Soklyda Chann; Worachet Kuntawunginn; Nillawan Buathong; Samon Nou; Douglas S Walsh; Stuart D Tyner; Jonathan J Juliano; Jessica Lin; Michele Spring; Delia Bethell; Jaranit Kaewkungwal; Douglas Tang; Char Meng Chuor; Prom Satharath; David Saunders
Journal:  PLoS One       Date:  2014-03-25       Impact factor: 3.240
  10 in total

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