Y Wang1, L Pan2, W Fan1, Z Zhou1, L Zhu1, Y Wang1, R Hu3. 1. Institute of Stomatology, Stomatology School & Hospital, Wenzhou Medical College, Wenzhou, 325027, China. 2. School of Laboratory Medicine and Life Science, Wenzhou Medical College, Wenzhou, 325035, China. 3. Institute of Stomatology, Stomatology School & Hospital, Wenzhou Medical College, Wenzhou, 325027, China. yldoccn@126.com.
Abstract
INTRODUCTION: A prospectively randomised, controlled animal study was conducted to analyse the influence of vagal injury on acute cardio-respiratory responses to blast injury. MATERIALS AND METHODS: We used a previously described model of blast-fragment combined injuries to divide dogs randomly into three groups: normal control, blast injury with fragment shot at the masseter and blast injury with fragment shot at the neck. The vagal histomorphologic changes were investigated by haematoxylin-eosin staining and immunocytochemical analysis of neuron-specific enolase and glial fibrillary acidic protein. The indices of respiration, heart rate, blood pressure and body temperature were recorded continuously before and after blast exposure. RESULTS: The vagal injury was more severe in the neck-injured than in the face-injured group. However, bradycardia, hypotension and absence of compensatory peripheral vasoconstriction, which are typically seen in animals subjected to blast injury without vagal nerve injuries, were partly inhibited when the vagal nerve was injured. CONCLUSION: A vagally mediated reflex, such as a cardio-respiratory system defensive reflex that caused shock, was observed immediately after blast pressure wave injury. These observations may have important implications for the emergency management of blast injury cases.
INTRODUCTION: A prospectively randomised, controlled animal study was conducted to analyse the influence of vagal injury on acute cardio-respiratory responses to blast injury. MATERIALS AND METHODS: We used a previously described model of blast-fragment combined injuries to divide dogs randomly into three groups: normal control, blast injury with fragment shot at the masseter and blast injury with fragment shot at the neck. The vagal histomorphologic changes were investigated by haematoxylin-eosin staining and immunocytochemical analysis of neuron-specific enolase and glial fibrillary acidic protein. The indices of respiration, heart rate, blood pressure and body temperature were recorded continuously before and after blast exposure. RESULTS: The vagal injury was more severe in the neck-injured than in the face-injured group. However, bradycardia, hypotension and absence of compensatory peripheral vasoconstriction, which are typically seen in animals subjected to blast injury without vagal nerve injuries, were partly inhibited when the vagal nerve was injured. CONCLUSION: A vagally mediated reflex, such as a cardio-respiratory system defensive reflex that caused shock, was observed immediately after blast pressure wave injury. These observations may have important implications for the emergency management of blast injury cases.
Entities:
Keywords:
Blast injury; Blood pressure and body temperature; Breathing rate; GFAP; Heart rate; Traumatic shock NSE; Vagal injury; Vagal reflex
Authors: Markus W Knöferl; Ulrich C Liener; Daniel H Seitz; Mario Perl; Uwe B Brückner; Lothar Kinzl; Florian Gebhard Journal: Shock Date: 2003-06 Impact factor: 3.454