OBJECTIVE: to evaluate liver regeneration in rats after partial hepatectomy of 60% with and without action diet supplemented with fatty acids through the study of the regenerated liver weight, laboratory parameters of liver function and histological study. METHODS: thirty-six Wistar rats, males, adults were used, weighing between 195 and 330 g assigned to control and groups. The supplementation group received the diet by gavage and were killed after 24h, 72h and seven days. Evaluation of regeneration occurred through analysis of weight gain liver, serum aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltranspeptidase, and mitosis of the liver stained with H&E. RESULTS: the diet supplemented group showed no statistical difference (p>0.05) on the evolution of weights. Administration of fatty acids post-hepatectomy had significant reduction in gamma glutamyltransferase levels and may reflect liver regeneration. Referring to mitotic index, it did not differ between period of times among the groups. CONCLUSION: supplementation with fatty acids in rats undergoing 60% hepatic resection showed no significant interference related to liver regeneration.
OBJECTIVE: to evaluate liver regeneration in rats after partial hepatectomy of 60% with and without action diet supplemented with fatty acids through the study of the regenerated liver weight, laboratory parameters of liver function and histological study. METHODS: thirty-six Wistar rats, males, adults were used, weighing between 195 and 330 g assigned to control and groups. The supplementation group received the diet by gavage and were killed after 24h, 72h and seven days. Evaluation of regeneration occurred through analysis of weight gain liver, serum aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltranspeptidase, and mitosis of the liver stained with H&E. RESULTS: the diet supplemented group showed no statistical difference (p>0.05) on the evolution of weights. Administration of fatty acids post-hepatectomy had significant reduction in gamma glutamyltransferase levels and may reflect liver regeneration. Referring to mitotic index, it did not differ between period of times among the groups. CONCLUSION: supplementation with fatty acids in rats undergoing 60% hepatic resection showed no significant interference related to liver regeneration.
Authors: Sebastião Barreto de Brito-Filho; Egberto Gaspar de Moura; Orlando José Dos Santos; Euler Nicolau Sauaia-Filho; Elias Amorim; Ewaldo Eder Carvalho Santana; Allan Kardec Dualibe Barros-Filho; Rennan Abud Pinheiro Santos Journal: Arq Bras Cir Dig Date: 2016 Jul-Sep
Authors: María Eugenia Cornide-Petronio; Ana Isabel Álvarez-Mercado; Mónica B Jiménez-Castro; Carmen Peralta Journal: Nutrients Date: 2020-01-21 Impact factor: 5.717