PURPOSE OF REVIEW: Natriuretic peptides, high-sensitivity cardiac troponins, and suppression of tumorigenicity 2 are novel biomarkers that reflect the intricate pathophysiology of heart failure and can thus be used for the diagnosis, management, and prognosis of heart failure. RECENT FINDINGS: This review article describes the significance of B-type natriuretic peptide (BNP), N-terminal prohormone of BNP, ST2, and cardiac troponins. We outline their new roles in guiding the management of heart failure as well as strong prognostic indicators for adverse cardiovascular outcomes. SUMMARY: By recognizing the diagnostic and prognostic significance of these biomarkers, clinicians can utilize these biomarkers to more accurately evaluate and risk stratify patients. These markers can also be used to help guide the medical management of heart failure. The best approach for an accurate diagnosis, management, and prognosis of heart failure will likely involve a multimarker panel of biomarkers, which may include high-sensitivity troponins, BNP, N-terminal prohormone of BNP, and ST2.
PURPOSE OF REVIEW: Natriuretic peptides, high-sensitivity cardiac troponins, and suppression of tumorigenicity 2 are novel biomarkers that reflect the intricate pathophysiology of heart failure and can thus be used for the diagnosis, management, and prognosis of heart failure. RECENT FINDINGS: This review article describes the significance of B-type natriuretic peptide (BNP), N-terminal prohormone of BNP, ST2, and cardiac troponins. We outline their new roles in guiding the management of heart failure as well as strong prognostic indicators for adverse cardiovascular outcomes. SUMMARY: By recognizing the diagnostic and prognostic significance of these biomarkers, clinicians can utilize these biomarkers to more accurately evaluate and risk stratify patients. These markers can also be used to help guide the medical management of heart failure. The best approach for an accurate diagnosis, management, and prognosis of heart failure will likely involve a multimarker panel of biomarkers, which may include high-sensitivity troponins, BNP, N-terminal prohormone of BNP, and ST2.
Authors: Dipal M Patel; Heather Thiessen-Philbrook; Jeremiah R Brown; Eric McArthur; Dennis G Moledina; Sherry G Mansour; Michael G Shlipak; Jay L Koyner; Peter Kavsak; Richard P Whitlock; Allen D Everett; David J Malenka; Amit X Garg; Steven G Coca; Chirag R Parikh Journal: Am Heart J Date: 2019-12-03 Impact factor: 4.749
Authors: Toshiaki Ohkuma; Min Jun; Mark Woodward; Sophia Zoungas; Mark E Cooper; Diederick E Grobbee; Pavel Hamet; Giuseppe Mancia; Bryan Williams; Paul Welsh; Naveed Sattar; Jonathan E Shaw; Kazem Rahimi; John Chalmers Journal: Diabetes Care Date: 2017-07-06 Impact factor: 19.112
Authors: Brynja Jónsdóttir; Marie Ziebell Severinsen; Fredrik von Wowern; Carmen San Miguel; Jens P Goetze; Olle Melander Journal: Int J Chron Obstruct Pulmon Dis Date: 2019-10-23
Authors: Nicole H M K Uszko-Lencer; Daisy J A Janssen; Swetlana Gaffron; Lowie E G W Vanfleteren; Eefje Janssen; Christ Werter; Frits M E Franssen; Emiel F M Wouters; Simon Rechberger; Hans-Peter Brunner La Rocca; Martijn A Spruit Journal: ESC Heart Fail Date: 2021-11-18