Literature DB >> 26813764

Legionella effectors reflect strength in diversity.

Iñaki Comas1.   

Abstract

The Legionella genus includes opportunistic human pathogenic species that invade human cells using effector proteins that evolved during association with their natural amoeba hosts. A new study compares the genomes of 41 Legionella species to identify nearly 6,000 effectors, providing insight into these species' evolution and pathogenic lifestyles.

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Year:  2016        PMID： 26813764     DOI： 10.1038/ng.3492

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  10 in total

1.  Genomic analysis of 38 Legionella species identifies large and diverse effector repertoires.

Authors:  David Burstein; Francisco Amaro; Tal Zusman; Ziv Lifshitz; Ofir Cohen; Jack A Gilbert; Tal Pupko; Howard A Shuman; Gil Segal
Journal:  Nat Genet       Date:  2016-01-11       Impact factor: 38.330

Review 2.  Bacterial remodelling of the host epigenome: functional role and evolution of effectors methylating host histones.

Authors:  Monica Rolando; Laura Gomez-Valero; Carmen Buchrieser
Journal:  Cell Microbiol       Date:  2015-08       Impact factor: 3.715

3.  Legionella pneumophila effector RomA uniquely modifies host chromatin to repress gene expression and promote intracellular bacterial replication.

Authors:  Monica Rolando; Serena Sanulli; Christophe Rusniok; Laura Gomez-Valero; Clement Bertholet; Tobias Sahr; Raphael Margueron; Carmen Buchrieser
Journal:  Cell Host Microbe       Date:  2013-04-17       Impact factor: 21.023

4.  Quantifying nonvertical inheritance in the evolution of Legionella pneumophila.

Authors:  Mireia Coscollá; Iñaki Comas; Fernando González-Candelas
Journal:  Mol Biol Evol       Date:  2010-10-20       Impact factor: 16.240

5.  Computational modeling and experimental validation of the Legionella and Coxiella virulence-related type-IVB secretion signal.

Authors:  Ziv Lifshitz; David Burstein; Michael Peeri; Tal Zusman; Kierstyn Schwartz; Howard A Shuman; Tal Pupko; Gil Segal
Journal:  Proc Natl Acad Sci U S A       Date:  2013-02-04       Impact factor: 11.205

6.  Recombination drives genome evolution in outbreak-related Legionella pneumophila isolates.

Authors:  Leonor Sánchez-Busó; Iñaki Comas; Guillermo Jorques; Fernando González-Candelas
Journal:  Nat Genet       Date:  2014-10-05       Impact factor: 38.330

Review 7.  From amoeba to macrophages: exploring the molecular mechanisms of Legionella pneumophila infection in both hosts.

Authors:  Pedro Escoll; Monica Rolando; Laura Gomez-Valero; Carmen Buchrieser
Journal:  Curr Top Microbiol Immunol       Date:  2013       Impact factor: 4.291

Review 8.  Measurably evolving pathogens in the genomic era.

Authors:  Roman Biek; Oliver G Pybus; James O Lloyd-Smith; Xavier Didelot
Journal:  Trends Ecol Evol       Date:  2015-04-14       Impact factor: 17.712

9.  Aggravating genetic interactions allow a solution to redundancy in a bacterial pathogen.

Authors:  Tamara J O'Connor; Dana Boyd; Marion S Dorer; Ralph R Isberg
Journal:  Science       Date:  2012-12-14       Impact factor: 47.728

10.  Comparative analyses of Legionella species identifies genetic features of strains causing Legionnaires' disease.

Authors:  Laura Gomez-Valero; Christophe Rusniok; Monica Rolando; Mario Neou; Delphine Dervins-Ravault; Jasmin Demirtas; Zoe Rouy; Robert J Moore; Honglei Chen; Nicola K Petty; Sophie Jarraud; Jerome Etienne; Michael Steinert; Klaus Heuner; Simonetta Gribaldo; Claudine Médigue; Gernot Glöckner; Elizabeth L Hartland; Carmen Buchrieser
Journal:  Genome Biol       Date:  2014       Impact factor: 13.583
  10 in total
  1 in total

Review 1.  Is anaerobic digestion a reliable barrier for deactivation of pathogens in biosludge?

Authors:  Qian Zhao; Yu Liu
Journal:  Sci Total Environ       Date:  2019-03-06       Impact factor: 7.963
  1 in total

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