Literature DB >> 26813345

Translational opportunities for targeting the Th17 axis in acute graft-vs.-host disease.

F Malard1,2,3,4, B Gaugler1,2, B Lamarthee1,2, M Mohty1,2,3.   

Abstract

Allogeneic stem cell transplantation (allo-SCT) is a curative therapy for different life-threatening malignant and non-malignant hematologic disorders. Acute graft-vs.-host disease (aGVHD) and particularly gastrointestinal aGVHD remains a major source of morbidity and mortality following allo-SCT, which limits the use of this treatment in a broader spectrum of patients. Better understanding of aGVHD pathophysiology is indispensable to identify new therapeutic targets for aGVHD prevention and therapy. Growing amount of data suggest a role for T helper (Th)17 cells in aGVHD pathophysiology. In this review, we will discuss the current knowledge in this area in animal models and in humans. We will then describe new potential treatments for aGVHD along the Th17 axis.

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Year:  2016        PMID： 26813345     DOI： 10.1038/mi.2015.143

Source DB:  PubMed          Journal:  Mucosal Immunol        ISSN： 1933-0219            Impact factor:   7.313


  116 in total

1.  Activated innate lymphoid cells are associated with a reduced susceptibility to graft-versus-host disease.

Authors:  J Marius Munneke; Andreas T Björklund; Jenny M Mjösberg; Karin Garming-Legert; Jochem H Bernink; Bianca Blom; Cynthia Huisman; Marinus H J van Oers; Hergen Spits; Karl-Johan Malmberg; Mette D Hazenberg
Journal:  Blood       Date:  2014-05-22       Impact factor: 22.113

2.  α-Mannan induces Th17-mediated pulmonary graft-versus-host disease in mice.

Authors:  Hidetaka Uryu; Daigo Hashimoto; Koji Kato; Eiko Hayase; Satomi Matsuoka; Reiki Ogasawara; Shuichiro Takahashi; Yoshinobu Maeda; Hiromi Iwasaki; Toshihiro Miyamoto; Shinobu Saijo; Yoichiro Iwakura; Geoffrey R Hill; Koichi Akashi; Takanori Teshima
Journal:  Blood       Date:  2015-03-04       Impact factor: 22.113

3.  Cutaneous GVHD is associated with the expansion of tissue-localized Th1 and not Th17 cells.

Authors:  Raewyn Broady; Jie Yu; Vickie Chow; Adisak Tantiworawit; Christine Kang; Kyra Berg; Magdalena Martinka; Mehran Ghoreishi; Jan Dutz; Megan K Levings
Journal:  Blood       Date:  2010-09-23       Impact factor: 22.113

Review 4.  Recent advances in IL-22 biology.

Authors:  Lauren A Zenewicz; Richard A Flavell
Journal:  Int Immunol       Date:  2011-03       Impact factor: 4.823

5.  TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology.

Authors:  Mandy J McGeachy; Kristian S Bak-Jensen; Yi Chen; Cristina M Tato; Wendy Blumenschein; Terrill McClanahan; Daniel J Cua
Journal:  Nat Immunol       Date:  2007-11-11       Impact factor: 25.606

6.  Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells.

Authors:  Eva V Acosta-Rodriguez; Laura Rivino; Jens Geginat; David Jarrossay; Marco Gattorno; Antonio Lanzavecchia; Federica Sallusto; Giorgio Napolitani
Journal:  Nat Immunol       Date:  2007-05-07       Impact factor: 25.606

7.  TGF-beta promotes Th17 cell development through inhibition of SOCS3.

Authors:  Hongwei Qin; Lanfang Wang; Ting Feng; Charles O Elson; Sandrine A Niyongere; Sun Jung Lee; Stephanie L Reynolds; Casey T Weaver; Kevin Roarty; Rosa Serra; Etty N Benveniste; Yingzi Cong
Journal:  J Immunol       Date:  2009-06-17       Impact factor: 5.422

8.  Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease.

Authors:  Lauren A Zenewicz; George D Yancopoulos; David M Valenzuela; Andrew J Murphy; Sean Stevens; Richard A Flavell
Journal:  Immunity       Date:  2008-12-19       Impact factor: 31.745

9.  Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid.

Authors:  Daniel Mucida; Yunji Park; Gisen Kim; Olga Turovskaya; Iain Scott; Mitchell Kronenberg; Hilde Cheroutre
Journal:  Science       Date:  2007-06-14       Impact factor: 47.728

10.  Phenotypic and functional features of human Th17 cells.

Authors:  Francesco Annunziato; Lorenzo Cosmi; Veronica Santarlasci; Laura Maggi; Francesco Liotta; Benedetta Mazzinghi; Eliana Parente; Lucia Filì; Simona Ferri; Francesca Frosali; Francesco Giudici; Paola Romagnani; Paola Parronchi; Francesco Tonelli; Enrico Maggi; Sergio Romagnani
Journal:  J Exp Med       Date:  2007-07-16       Impact factor: 14.307
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  11 in total

1.  A panel of 4 biomarkers for the early diagnosis and therapeutic efficacy of aGVHD.

Authors:  Xiaoping Li; Ting Chen; Qiangguo Gao; Wei Zhang; Yunshuo Xiao; Wen Zhu; Lingyu Zeng; Zhenyu Li; Shijie Yang; Rui Wang; Xiaoqi Wang; Yimei Feng; Xi Zhang
Journal:  JCI Insight       Date:  2019-08-22

2.  CD40 Activity on Mesenchymal Cells Negatively Regulates OX40L to Maintain Bone Marrow Immune Homeostasis Under Stress Conditions.

Authors:  Barbara Bassani; Claudio Tripodo; Paola Portararo; Alessandro Gulino; Laura Botti; Claudia Chiodoni; Elena Jachetti; Niccolò Bolli; Marilena Ciciarello; Korinna Joehrens; Ioannis Anagnostopoulos; Il-Kang Na; Antonio Curti; Mario P Colombo; Sabina Sangaletti
Journal:  Front Immunol       Date:  2021-05-18       Impact factor: 7.561

3.  Anti-ICOS mAb Targets Pathogenic IL-17A-expressing Cells in Canine Model of Chronic GVHD.

Authors:  Maura H Parker; Diane Stone; Kraig Abrams; Melissa Johnson; Noa Granot; Rainer Storb
Journal:  Transplantation       Date:  2021-05-01       Impact factor: 5.385

4.  Targeting Inflammatory T Helper Cells via Retinoic Acid-Related Orphan Receptor Gamma t Is Ineffective to Prevent Allo-Response-Driven Colitis.

Authors:  Vera Buchele; Benjamin Abendroth; Maike Büttner-Herold; Tina Vogler; Johanna Rothamer; Sakhila Ghimire; Evelyn Ullrich; Ernst Holler; Markus F Neurath; Kai Hildner
Journal:  Front Immunol       Date:  2018-05-25       Impact factor: 7.561

5.  Human iPSC-MSCs prevent steroid-resistant neutrophilic airway inflammation via modulating Th17 phenotypes.

Authors:  Shu-Bin Fang; Hong-Yu Zhang; Ai-Yun Jiang; Xing-Liang Fan; Yong-Dong Lin; Cheng-Lin Li; Cong Wang; Xiang-Ci Meng; Qing-Ling Fu
Journal:  Stem Cell Res Ther       Date:  2018-05-24       Impact factor: 6.832

Review 6.  Immune Equilibrium Depends on the Interaction Between Recognition and Presentation Landscapes.

Authors:  Daniil Shevyrev; Valeriy Tereshchenko; Vladimir Kozlov
Journal:  Front Immunol       Date:  2021-07-30       Impact factor: 7.561

7.  Rejection of intestinal allotransplants is driven by memory T helper type 17 immunity and responds to infliximab.

Authors:  Alexander Kroemer; Leonid Belyayev; Khalid Khan; Katrina Loh; Jiman Kang; Anju Duttargi; Harmeet Dhani; Mohammed Sadat; Oswaldo Aguirre; Yuriy Gusev; Krithika Bhuvaneshwar; Bhaskar Kallakury; Christopher Cosentino; Brenna Houlihan; Jamie Diaz; Sangeetha Moturi; Nada Yazigi; Stuart Kaufman; Sukanya Subramanian; Jason Hawksworth; Raffaelle Girlanda; Simon C Robson; Cal S Matsumoto; Michael Zasloff; Thomas M Fishbein
Journal:  Am J Transplant       Date:  2020-09-25       Impact factor: 8.086

8.  Intestinal Microbiota at Engraftment Influence Acute Graft-Versus-Host Disease via the Treg/Th17 Balance in Allo-HSCT Recipients.

Authors:  Lijie Han; Hua Jin; Lizhi Zhou; Xin Zhang; Zhiping Fan; Min Dai; Qianyun Lin; Fen Huang; Li Xuan; Haiyan Zhang; Qifa Liu
Journal:  Front Immunol       Date:  2018-04-24       Impact factor: 7.561

9.  High-Dose IL-2 Skews a Glucocorticoid-Driven IL-17+IL-10+ Memory CD4+ T Cell Response towards a Single IL-10-Producing Phenotype.

Authors:  Elizabeth H Mann; Leona Gabryšová; Paul E Pfeffer; Anne O'Garra; Catherine M Hawrylowicz
Journal:  J Immunol       Date:  2018-12-31       Impact factor: 5.422

10.  Bendamustine with total body irradiation conditioning yields tolerant T-cells while preserving T-cell-dependent graft-versus-leukemia.

Authors:  Jessica Stokes; Emely A Hoffman; Megan S Molina; Nicole Kummet; Richard J Simpson; Yi Zeng; Emmanuel Katsanis
Journal:  Oncoimmunology       Date:  2020-04-30       Impact factor: 8.110
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