Literature DB >> 26812010

KIF1Bβ and Neuroblastoma: Failure to Divide and Cull.

Craig Blackstone1.   

Abstract

Neuroblastomas are associated with KIF1Bβ mutations within tumor suppressor region 1p36. In this issue of Developmental Cell, Li et al. (2016) show that KIF1Bβ binding releases calcineurin autoinhibition, leading to dephosphorylation of the DRP1 GTPase and subsequent mitochondrial fragmentation. KIF1Bβ impairment causes mitochondrial hyperfusion, impairing developmental apoptosis and promoting tumorigenesis.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2016        PMID： 26812010      PMCID： PMC5584681          DOI： 10.1016/j.devcel.2016.01.005

Source DB:  PubMed          Journal:  Dev Cell        ISSN： 1534-5807            Impact factor:   12.270


  10 in total

Review 1.  Fusion and fission: interlinked processes critical for mitochondrial health.

Authors:  David C Chan
Journal:  Annu Rev Genet       Date:  2012-08-29       Impact factor: 16.830

2.  SUMO wrestling with Drp1 at mitochondria.

Authors:  Caroline A Anderson; Craig Blackstone
Journal:  EMBO J       Date:  2013-04-30       Impact factor: 11.598

3.  Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer.

Authors:  Sungwoo Lee; Eijiro Nakamura; Haifeng Yang; Wenyi Wei; Michelle S Linggi; Mini P Sajan; Robert V Farese; Robert S Freeman; Bruce D Carter; William G Kaelin; Susanne Schlisio
Journal:  Cancer Cell       Date:  2005-08       Impact factor: 31.743

4.  RNA helicase A is a downstream mediator of KIF1Bβ tumor-suppressor function in neuroblastoma.

Authors:  Zhi Xiong Chen; Karin Wallis; Stuart M Fell; Veronica R Sobrado; Marie C Hemmer; Daniel Ramsköld; Ulf Hellman; Rickard Sandberg; Rajappa S Kenchappa; Tommy Martinson; John I Johnsen; Per Kogner; Susanne Schlisio
Journal:  Cancer Discov       Date:  2014-01-27       Impact factor: 39.397

5.  A calcineurin docking motif (LXVP) in dynamin-related protein 1 contributes to mitochondrial fragmentation and ischemic neuronal injury.

Authors:  Andrew M Slupe; Ronald A Merrill; Kyle H Flippo; Mark A Lobas; Jon C D Houtman; Stefan Strack
Journal:  J Biol Chem       Date:  2013-03-13       Impact factor: 5.157

6.  The 1p36 Tumor Suppressor KIF 1Bβ Is Required for Calcineurin Activation, Controlling Mitochondrial Fission and Apoptosis.

Authors:  Shuijie Li; Stuart M Fell; Olga Surova; Erik Smedler; Karin Wallis; Zhi Xiong Chen; Ulf Hellman; John Inge Johnsen; Tommy Martinsson; Rajappa S Kenchappa; Per Uhlén; Per Kogner; Susanne Schlisio
Journal:  Dev Cell       Date:  2016-01-25       Impact factor: 12.270

Review 7.  1p36 tumor suppression--a matter of dosage?

Authors:  Kai-Oliver Henrich; Manfred Schwab; Frank Westermann
Journal:  Cancer Res       Date:  2012-11-20       Impact factor: 12.701

8.  A germline mutation of the KIF1B beta gene on 1p36 in a family with neural and nonneural tumors.

Authors:  I-Tien Yeh; Romina E Lenci; Yuejuan Qin; Kalyan Buddavarapu; Azra H Ligon; Emmanuelle Leteurtre; Christine Do Cao; Catherine Cardot-Bauters; Pascal Pigny; Patricia L M Dahia
Journal:  Hum Genet       Date:  2008-08-26       Impact factor: 4.132

9.  CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression.

Authors:  Chris M Egan; Ulrika Nyman; Julie Skotte; Gundula Streubel; Siobhán Turner; David J O'Connell; Vilma Rraklli; Michael J Dolan; Naomi Chadderton; Klaus Hansen; Gwyneth Jane Farrar; Kristian Helin; Johan Holmberg; Adrian P Bracken
Journal:  Dev Cell       Date:  2013-08-12       Impact factor: 12.270

10.  Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria.

Authors:  G M Cereghetti; A Stangherlin; O Martins de Brito; C R Chang; C Blackstone; P Bernardi; L Scorrano
Journal:  Proc Natl Acad Sci U S A       Date:  2008-10-06       Impact factor: 11.205
  10 in total
  2 in total

1.  KIF1Bβ increases ROS to mediate apoptosis and reinforces its protein expression through O 2- in a positive feedback mechanism in neuroblastoma.

Authors:  Clara Angelina; Irene Sze Ying Tan; Zhang'e Choo; Oswald Zhao Jian Lee; Shazib Pervaiz; Zhi Xiong Chen
Journal:  Sci Rep       Date:  2017-12-04       Impact factor: 4.379

2.  Discovery, characterization and potential roles of a novel NF-YAx splice variant in human neuroblastoma.

Authors:  Lucia Cappabianca; Antonietta Rosella Farina; Lucia Di Marcotullio; Paola Infante; Daniele De Simone; Michela Sebastiano; Andrew Reay Mackay
Journal:  J Exp Clin Cancer Res       Date:  2019-12-05
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.